دانشکده داروسازی

فغاليتهاي تحقيقاتي دكتر افراسيابي

امتیاز کاربران

ستاره غیر فعالستاره غیر فعالستاره غیر فعالستاره غیر فعالستاره غیر فعال
 

 

 

 

 

رزومه
Curriculum Vitae (CV)

1) مشخصات فردي

نام : هادي
نام خانوادگي: افراسيابي گرکاني
جنسيت: مرد
رشته تحصيلي: داروسازي
گروه آموزشي: فارماسيوتيکس
مرتبه علمي: استاد
آدرس محل كار: مشهد- بلوار وکيل آباد- مجتمع دانشگاهي پرديس- دانشکده داروسازي- دانشگاه علوم پزشکي مشهد
تلفن محل كار:  31801321(9851+)
آدرس پست الكترونيك: afrasiabih[at]mums.ac.ir

2) تحصيلات دانشگاهي

1- دكتراي داروسازي (دانشكده داروسازي مشهد - سال 1368)
2- Ph.D. داروسازي صنعتي (انگلستان - سال 1375، (Liverpool John Moores University,UK)
 
3) تجربيات حرفه اي
 
1) مدير امور دارويي و مسؤل فني داروخانه دولتي – شهرستان فردوس- (بهمن 1368 لغايت آبان 1370)
2) هيئت علمي پيماني دانشکده داروسازي- دانشگاه علوم پزشکي مشهد (اسفند 1375 تا بهمن 1380)
3) هيئت علمي رسمي دانشکده داروسازي- دانشگاه علوم پزشکي مشهد (بهمن 1380 تا کنون)

4) تجربيات آموزشي

1) مدرس دروس فيزيکال فارماسي 2، فارماسيوتيکس 2 و5 نظري و عملي، کارآموزي داروخانه، جهت دانشجويان دروه عمومي
2) مدرس دروس فيزيکال فارماسي، داروسازي صنعتي، و کنترل فيزيکو شيميايي جهت دانشجويان PhD دوره هاي فارماسيوتيکس و کنترل فيزيکو شيميائي
3) مسئول دروس کارآموزي مقدماتي صنعت و کارورزي صنعت در عرصه

5) عناوين و امتيازات ويژه

1- نفر سوم جشنواره رازي -1384
2) پژوهشگر برتر دانشگاه علوم پزشکي مشهد- سال 1383
3) مترجم برتردانشگاه علوم پزشکي مشهد 1386
4) انتخاب کتاب فارماسيوتيکس 1و 2 به عنوان کتاب برگزيده در شانزدهمين دوره کتاب برتر دانشگاهي سال 1385 در جشنواره پژوهش دانشگاه تهران سال 1385

6) فعاليت هاي پژوهشي

الف) انتشار مقاله در ژورنال‎هاي علمي پژوهشي بين المللي:

1. Afrasiabi Garekani, H.,Nokhodchi, A.,Amirpour Rayeni, M,Sadeghi, F. Preparation and characterization and release properties of Eudragit RS based ibuprofen pellets prepared by extrusion spheronization. Effect of binder type and concentration. Drug Dev. Ind. Pharm. In Press

2. Sadeghi, F., Shahabi, M., Afrasiabi Garekani, H. Comparison of physicomechanical properties of films prepared from organic solutions and aqueous dispersion of Eudragit RL. DARU 19(2) (2011) 100-106.

3. Sadeghi, F., Hijazi, H., Afrasiabi Garekani, H. Production of ibuprofen pellets containing high amount of rate retarding Eudragit RL using PEG400 and investigation of their physicomechanical properties. Iranian Journal of Basic Medical Sciences. 14 (2011) 383-390.

4. Sadeghi F, Sanadgol E., Afrasiabi Garekani H. The effect of granulating liquid and curing on the physicomechanical and release properties of pellets containing ibuprofen and Eudragit RL prepared by extrusion spheronization. Pharmaceutical Sciences, Journal of Faculty of Pharmacy, Tabriz University of Medical Sciences 17 (2011) 103-118.

5. Sadeghi F., Rakhshan M., Afrasiabi Garekani H. Preparation and evaluation of microcapsules containing propranolol hydrochloride using Eudragit polymers Pharmaceutical Sciences, Journal of Faculty of Pharmacy, Tabriz University of Medical Sciences 17 ( 2011) 189 – 200.

6. Akhgari, A., Farahmand, F., Afrasiabi Garekani, H., Sadeghi, F., Vandamme, T.F. The effect of pectin on swelling and permeability characteristics of free films containing Eudragit RL and/or RS as a coating formulation aimed for colonic delivery. DARU 18 (2010) 91-96.

7. Akhgari, A., Afrasiabi Garekani, H., Sadeghi, F. Combination of inulin and time dependent polymethacrylates as a coating system to achieve colonic delivery of indomethacin. DARU 17 (2009) 199-208.

8. Sadeghi F., Oskooie R.K., Nasirli H., Afrasiabi Garekani H., 2009, Effect of granulation process on physicomechanical properties of granules and compaction behavior of hydroxypropyl methylcellulose with different degrees of methoxy/hydroxypropyl substitutes., Tabriz Journal of Pharmaceutical Sciences., 15, 93-102

9. Abbaspour, M.R., Sadeghi, F., Afrasiabi Garekani, H., Design and study of ibuprofen disintegrating sustained release tablets comprising coated pellets. Eur. J. Pharm. Biopharm. 68 (2008) 747-759.

10. Abbaspour, M.R., Sadeghi, F., Afrasiabi Garekani, H., Thermal treating as a tool to produce plastic pellets based on Eudragit RS PO and RL PO aimed for tableting. Eur. J. Pharm. Biopharm. 67 (2008) 260-267.

11. Ronald Ross Watson, Sherma Zibadi, Houshang Rafatpanah, Farahzad Jabbari, Ramin Ghasemi, Javad ghafari, Hadi Afrasiabi, Lai Yeap Foo, Reza Faridhosseini, 2008, Oral administration of purple passion fruit peel extract reduces wheeze and cough and improves shortness of breath in adults with asthma., Nutrition Research, 28, 166-171

12. Sadeghi F., Eidi M., Ansaripoor N., Afrasiabi Garekani H., 2008, Preparation and evaluation of microsphere containing diclofenac sodium and Eudragit RS or RL as oral sustained release multiparticulate delivery system., Tabriz Journal of Pharmaceutical Sciences., Spring, 9-18

13. Sadeghi, F., Mosaffa, F., Afrasiabi Garekani, H. Effect of particle size, compaction force and presence of aerosil 200 on the properties of matrices prepared from physical mixture of propranolol hydrochloride and Eudragit RS or RL. Iranian Journal of Basic Medical Sciences. 10 (2007) 197-205.

14. Akhagri, A., Sadeghi, F., Afrasiabi Garekani, H. Combination of time-dependent and pH-dependent polymthacrylates as a single coating formulation for colonic delivery of indomethacin pellets. Int. J. Pharm. 320 (2006) 137-142.

15. Akhgari, A., Farahmand, F., Afrasiabi Garekani, H., Sadeghi, F., Vandamme, T.F., Permeability and swelling studies on free films containing inulin in combination with different polymethacrylates aimed for colonic drug delivery. Eur. J. Pharm. Sci. 28 (2006) 307-314.

16. Sadeghi, F., Afrasiabi Garekani H., Ghodsi A., 2006, Evaluation of solid dispersion systems of acetaminophen and ethyl cellulose, eudragit RS or RL and the effect of solvent used in preparation of these systems on characteristics of matrices, Tabriz Journal of Pharmaceutical Sciences., Spring, 47-54

17. Abbaspour, M.R., Sadeghi, F., Afrasiabi Garekani, H., 2005, Effect of drug loading on physicomechanical and release properties of ibuprofen pellets prepared by extrusion-spheronization, Tabriz Journal of Pharmaceutical Sciences., 2, 55-64

18. Abbaspour, M.R., Sadeghi, F., Afrasiabi Garekani, H. Preparation and characterization of ibuprofen pellets based on Eudragit RS PO and RL PO or their combination. Int. J. Pharm., 303 (2005) 88-94.

19. Akhgari A., Afrasiabi Garekani, H., Sadeghi, F. and Azimaie, M. Statistical optimization of indomethacin pellets coated with pH-dependent methacrylic polymers for possible colonic drug delivery. Int. J. Pharm.,305(2005)22-30.

20. Sadeghi, F., Afrasiabi Garekani, H., Goli, F. Tableting of Eudragit RS and propranolol hydrochloride solid dispersion: Effect of particle size, compaction force and plasticizer addition on drug release. Drug Dev. Ind. Pharm. 30 (2004) 759-766.

 

21. Afrasiabi Garekani, H., Sadeghi, F. Salary, M. 2004, Dissolution study of acetaminophen crystallized in the presence of polyvinylpyrrolidone., J. Drug Del. Sci. Tech. 14 (2004) 141-146.

22. Sadeghi, F., Afrasiabi Garekani, H., Sadr, A. Influence of polymer viscosity and plasticizer addition on ethylcellulose matrix characteristics prepared from solid dispersion system. S.T.P. PHARMA SCIENCE. 13 (2003) 105-110.

23. Sadeghi, F. Afrasiabi Garekani, H., Sadeghi, R. Comparison of ethylcellulose matrix characteristics prepared by solid dispersion technique or physical mixing. DARU, 11 (2003) 7-13.

 

24. Garekani, H.A.,Sadeghi, F., Firouzpoor, A. The influence of propylene glycol and moisture on the compaction properties of acetaminophen granules. S.T.P. PHARMA SCIENCE. 13 (2003) 335-339.

25. Garekani, H.A.,Sadeghi, F., Ghazi, A. Increasing the aqueous solubility of acetaminophen in presence of polyvinylpyrolidone and investigation of the mechanisms involved. Drug Dev. Ind. Pharm. 29 (2003) 173-179.

26. H. Afrasiabi Garekani, F. Sadeghi, A. Ghazi, 2002, Effect of polyvinylpyrrolidone on the aqueous solubility of acetaminophen and investigation of their interaction mechanisms, Iranian Journal of Basic Medical Sciences, 5, 53-58

27. F. Sadeghi, H. Afrasiabi Garekani, Z. Farzadnia, 2001, Effect of polymer viscosity, polymer particle size and compaction force on the diclofenac sodium release from ethyl cellulose matrices., Tabriz Journal of Pharmaceutical Sciences., Spring, 45-56

 

28. Garekani, H.A.,Sadeghi, F., Badiee, A., Mostafa, S.A., Rajabi-Siahboomi, A.R. Crystal habit modifications of ibubrufen and their physicomechanical characteristics. Drug Dev. Ind. Pharm. 27 (2001) 803-809.

 

29. Hadi A. Garekani, James L. Ford, Michael H. Rubinstein, Ali R. Rajabi-Siahboomi, 2001. Effect of compression force, compression speed and particle size on the compaction properties of paracetamol., Drug Development and Industrial Pharmacy, 27, 935-942

30. H. Afrasiabi Garekani, F. Sadeghi, A. Firoozpour, 2000,The effect of moisture content on the compaction properties of acetaminophen granules and comparison with the effect of plasticizer., Iranian Journal of Basic Medical Sciences, 3, 113-122

31. Hadi A. Garekani, James L. Ford, Michael H. Rubinstein, Ali R. Rajabi-Siahboomi, 2000. Highly compressible paracetamol: I. Crystallization and characterization, International Journal of Pharmaceutics, 208, 87-99

 

32. Hadi A. Garekani, James L. Ford, Michael H. Rubinstein, Ali R. Rajabi-Siahboomi, 2000. Highly compressible paracetamol: II. Compression properties, International Journal of Pharmaceutics, 208, 101-110

 

33. Hadi A. Garekani, James L. Ford, Michael H. Rubinstein, Ali R. Rajabi-Siahboomi, 1999. Formation and compression characteristics of prismatic polyhedral and thin plate-like crystals of paracetamol., International Journal of Pharmaceutics., 187, 77-89

34. H. Afrasiabi Garekani, F. Sadeghi, A. Badiee, 1999, Investigation of the physico-mechanical properties of modified crystals of ibuprofen., Iranian Journal of Basic Medical Sciences, 2, 8-17

ب) ارائه مقاله دركنگره ها يا سمينارهاي بين المللي:

1. F. Sadeghi, Z. Fatemi Moghaddam, H. Afrasiabi Garekani.Preparation of Sustained Release Microparticles Containing Theophylline and Eudragit RS Using Spray Drying Technique: Comparison Between Organic Solution and Aqueous Dispersion of Polymer. 39th Annual Meeting & Exposition of the Controlled Release Society. July 2012, Qubec city, Canada.

2. H.AfrasiabiGarekani,M. khattab, F. Sadeghi. ParticleEngineeringof AcetaminophenVia Spray Drying FromHydro-alcoholicSolutions: Improvement In Dissolution Rate. 39th Annual Meeting & Exposition of the Controlled Release Society. July 2012, Qubec city, Canada.

 

 

3. Hadi Afrasiabi Garekani, Maisam Rakhshan, Fatemeh Sadeghi, Preparation and evaluation of propranolol HCL microcapsules containing Eudragit polymers using emulsion solvent evaporation method, . 3rd PharmSci fair, 2011. Prague, Czech.

4. F. Sadeghi, Amirpoor Rayeni, M., Afrasiabi Garekani, H.The effect of HPMC type and concentration on physicomechanical and release properties of ibuprofen and Eudragit RS pellets prepared by extrusion spheronization. 3rd PharmSci fair, 2011. Prague, Czech.

5. F. Sadeghi, M. Amirpour Rayeni, H. Afrasiabi Garekani. Comparison of PVP K30, PVP K90 and HPMC 6cps as binder in preparation of Eudragit based ibuprofen matrix pellets prepared by extrusion-spheronization. (Oral presentation) 5th Iranian Controlled Release Conference, Mashhad, Iran, October 2011.

6. H. Afrasiabi Garekani, M. Torab, F. Sadeghi. Preparation of spray dried acetaminophen particles: Comparison of solution feed and suspension feed. 5th Iranian Controlled Release Conference, Mashhad, Iran, October 2011.

7. A. Homayouni, H. Afrasiabi Garekani, M. Torab, F. Sadeghi. The influence of PVP on solid states and physic-mechanical properties of spray dried acetaminophen particles obtained from aqueous solutions. 5th Iranian Controlled Release Conference, Mashhad, Iran, October 2011.

8. S. Sajadi, H. Afrasiabi Garekani, F. Sadeghi. Evaluation of Eudragit RS or RL in preparation of sustained release indomethacin multiple unit dosage form without application of coating. 4th Iranian Controlled Release Conference, Zanjan, Iran, October 2009.

9. F. Sadeghi, M.R. Abbaspour, H. Afrasiabi Garekani. The effect of coating level on mechanical and release properties of cured Eudargit based ibuprofen pellets. Pharmaceutical Science World Congress, Amsterdam, Netherland, April 2007.

10. H. Afrasiabi Garekani, A. Akhgari, F. Sadeghi. Comparison of permeability and swelling characteristics of free films containing pectin or inulin in combination with time dependent polymethaacrylate aimed for colonic drug delivery. Pharmaceutical Science World Congress, Amsterdam, Netherland, April 2007.

11. F.Sadeghi, M.R. Abbaspour, F., Tayarani, H. Afrasiabi Garekani. Mechanical and release behavior of ibuprofen pellets based on Eudragit RL plasticized with triethylcitrate. Biritish Pharmaceutical Conference, Manchester, UK, September 2006.

12. H. Afrasiabi Garekani, A. Akhgary, F. Sadeghi. Combination of Inulin as a bacterially degradable polysaccharide and Eudragit RS to achieve colon delivery of indomethacin pellets. Biritish Pharmaceutical Conference, Manchester, UK, September 2006.

13. F.Sadeghi, M.R. Abbaspour, H. Afrasiabi Garekani. Effect of thermal treating on release and physicomechanical properties of ibuprofen pellets based on Eudragit RS and RL. 2nd EUFEPS Conference on optimising drug delinery and formulation: Evaluation of drug delivery systems issues and perspectives ( Paris, France, November 2005)

14. H. Afrasiabi Garekani, A. Akhgary, F. Sadeghi, Combination of time-dependent and pH-dependent polymethacrylates as a single coating formulation for colonic delivery of indomethacin pellets. 2nd EUFEPS Conference on optimising drug delivery and formulation: Evaluation of drug delivery systems issues and perspectives ( Paris, France, November 2005)

15. F. Sadeghi, H.A. Garekani, E.H. Moase, O. Meyer, T.M. Allen, Binding method for NGR-targeted liposomal doxorubicin using cells expressing the angiogenic marker CD13., Lipids, Liposomes, and Biomembranes Conference (Vancouver, Canada, July 2005).

16. Sadeghi, F., Abbaspour, M.R., Afrasiabi Grekani, H. Preparation and characterization of ibuprofen pellets based on Eudragit RS and RL or their combination. Biritish Pharmaceutical Conference, Manchester, UK, September 2004.

17. Afrasiabi Garekani, H., Akhgari, A., Sadeghi, F. Indomethacin release from pellets coated with Eudragit S100 and Eudargit L100 combinations in media with different pH: an approach to colon delivery. Biritish Pharmaceutical Conference, Manchester, UK, September 2004.

18. Sadeghi, F., Afrasiabi Grekani, H., Goli, F. Solid dispersion of Eudragit RS and propranolol hydrochloride: Effect of particle size, compaction pressure and plasticizer addition. Biritish Pharmaceutical conference, Harrogate, UK, September 2003.

19. Afrasiabi Garekani, Sadeghi, F., Salary, M. Dissolution study of paracetamol crystalised in the presence of polyvinylpyrrolidon (PVP). Biritish Pharmaceutical conference, Harrogate, UK, September 2003.

20. Afrasiabi Garekani, H.,Sadeghi, F., Badiee, A., Rajabi-Siahbomi, A.R. Crystal habit modifications of ibuprofen and their physico-mechanical characteristics.19 th Pharmaceutical Technology Conference, Baveno- Stresa, Italy, April 2000. Proceedings 19th Pharmaceutical Technology conferenec 2 (2000) 324-333.

 

21. Hadi A. Garekani, James L. Ford, Michael H. Rubinstein, Ali R. Rajabi-Siahboomi, Manipulation of acetaminophen crystals for direct compression., 10th American Association of Pharmaceutical Scientists Conference (Seattle, USA, October, 1996)

22. Hadi A. Garekani, James L. Ford, Michael H. Rubinstein, Ali R. Rajabi-Siahboomi, Highly compressible paracetamol: Crystallization and characterization., 15th pharmaceutical Technology Conference (Oxford, UK, March 1996)

(This paper was awarded the best orally presentation of the 15th Pharmaceutical Technology Conference.)

23. Hadi A. Garekani,James L. Ford, Michael H. Rubinstein, Ali R. Rajabi-Siahboomi, Habit Modification of paracetamol crystals and their tableting characteristics., 15th pharmaceutical Technology Conference (Oxford, UK, March, 1996)

24. Hadi A. Garekani, James L. Ford, Michael H. Rubinstein, Ali R. Rajabi-Siahboomi, Effect of crystal habit on the compaction properties of paracetamol., British Pharmaceutical Conference (Warwick, UK, September 1995)

     

7- كتب تأليف/ ترجمه شده

الف) كتب تأليف شده:

ب) كتب ترجمه شده:

1) فارماسيوتيکس دانش طراحي اشکال داروئي جلد اول 1384.
2) فارماسيوتيکس دانش طراحي اشکال داروئي جلد دوم 1385.

8- مسئولیت های اجرائی

  1. مسئول دروس کارآموزي مقدماتي صنعت و کارورزي صنعت در عرصه از سال 1387
  2. 2. مسئول آزمایشگاه فارماسيوتيکس از 27/10/1384 لغايت 19/5/1387
  3. 3. مسئول آزمایشگاه تخصصی داروسازی از 19/5/1387تا کنون
  4. 4. عضو هیئت تحریریه مجله علوم دارويي تبريز از 28/5/86 تا کنون
  5. 5. عضو بورد تخصصي فارماسيوتيکس از 1383-1385
  6. 6. عضو شورای پژوهشی دانشگاه علوم پزشکي مشهد از 3/3/1378لغايت 3/3/1382
  7. 7. عضو تمام وقت مرکز تحقیقات علوم داروئی از 17/8/1380 تا کنون
  8. 8. استاد مشاور دانشجویان داروسازي
  9. 9. مدير پ‍ژوهشي دانشگاه از 1378 لغايت 1381

9- علایق پژوهشی

-Modification of drug crystals to improve their physico-mechanical properties,
-Characterization of drug crystals using different techniques such as X-ray powder diffraction, thermal analysis, FTIR, SEM
-Investigation of the compression properties of drugs and excipients,
-Formulation of solid dosage forms,
-Design and development of solid dispersion systems in order to modify the drug release behavior,
-Design and development of colon delivery systems,
-Design and development of sustained release systems,
-Tableting,
-Pelletization,
-Film coating,
-Microencapsulation,