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Name: Gholamreza Karimi Date and place birth: 1968, Tehran, Iran Nationality: Iranian Material status: Married (two daughter)
Education: Pharm.D:1992: School of Pharmacy, Mashhad, Iran Ph. D: 1999: Dep of Pharmacology and Toxicology, School of Pharmacy, Tehran, Iran Assistant Professor: 2000-2004 (Mashhad University of Medical Sciences) Associate Professor: 2004-2008 (Mashhad University of Medical Sciences) Professor 2009: up to now (Mashhad University of Medical Sciences) Fellowship: Montreal Heart Institute (Canada) 2013: The role of MicroRNA in oxidative stress of heart
Positions: Head of pharmacology and toxicology, Dep, 2000-2002 Manager of pharmacology Lab, 2000 up to now Manager of Mashhad drug and poison information center, 2000 up to 2012 Deputy food and drug organization in Mashhad University 2005 up to 2012 Teaching Experiences Cardiovascular Pharmacology (Pharm D, PhD students) Cardiovascular Toxicology (Pharm D students) CNS Toxicology (Pharm D students) Drug Information and Pharmacy Practice (Pharm D students) Natural Toxins (MSc. students)
Pharmacology of Vasoactive Peptide (Ph.D. students) Organ ( heart, liver, kidney) Toxicity (Ph.D. students) Forensic Toxicology (Ph.D. students) Drug and poison information resources (Ph.D student) Books Drugs and Herbs Interaction 2005 Natural toxin ( farsi edition), MUMS, 2012 Natural toxin ( 2 chapter , English), springer, 2014 Encyclopedia of toxicology ( 6 monograph, English), Elsevier, 2014
Some Publication Maternal Exposure to Silymarin Leads to Phatological Changes in mouse Foetuses. Gholami, M. ; Moallem, S.A.; Afshar, M. ; Etemad, L. * ; Karimi, G. Pharmacology online, Aug. 2015 • vol.2 • Effects of silymarin on neuropathic pain and formalin‐induced nociception in mice. Faezeh Vahdati Hassani , Ramin Rezaee , Hasan Sazegara, Mahmoud Hashemzaei , Kobra Shirani , Gholamreza Karimi *. Iran J Basic Med Sci, Vol. 18, No. 7, Jul 2015 Effect of gold nanoparticles on postoperative peritoneal adhesions in rats. Amir Hooshang Mohammadpour, Alireza Tavassoli, Mohammad Reza Khakzad, Elahe Zibaee, Mohammad ,AfsharMahmoud Hashemzaei , Gholamreza Karimi* . Nanomed J, Vol. 2, No. 3, Summer 2015 Kobra Shirani ,Faezeh Vahdati Hassani ,Kamal Razavi-Azarkhiavi ,Somayeh Heidari ,Bamdad Riahi Zanjani ,Gholamreza Karimi Enviromental toxicology and pharmacology . 2015 May;39(3):1262-1275 Ursolic acid induced apoptotic cell death following activation of caspases in isolated human melanoma cells. Mahmoud Mahmoudi, Shahrzad Zamani Taghizadeh Rabe, Mahdi Balali-Mood, Gholamreza Karimi, ,Nafiseh Tabasi and Bamdad Riahi-Zanjani* Cell Biol Int,39(2015) 230–236. Efficacy of orally administered montmorillonite for acute iron poisoning detoxification in rat. Parisa Mirhoseini Moosavi, Ali Reza Astaraei ,Alireza Karimi, Mohammad Moshiri, Leila Etemad, Majid Zeinalid, Gholamreza Karimi Applied Clay Science 103 (2015) 62–66. Crocin Effects on Human Myeloma Cells Regarding Intracellular Redox State, DNA Fragmentation, and Apoptosis or Necrosis Profile. Ramin Rezaee, Khadijeh Jamialahmadi , Bamdad Riahi Zanjani, Mahmoud Mahmoudi Jundishapur J Nat Pharm Prod. 2014 November; 9(4). Serum cytokine profiles of Khorasan veterans 23 years after sulfur mustard exposure. Bamdad Riahi-Zanjani, Mahdi Balali-Mood, Seyed-Reza Mousavi, Gholamreza Karimi, Mahmood Sadeghia, Elham Shirmast, Mahmoud Mahmoudi. Cytokine. 2014 Dec;70(2):161-4. A Sahebnasagh , Karimi, G*, SA Mohajeri. Food Anal. Methods. (2014) 7:1–8. A survey of aflatoxins in sesame seeds imported into Khorasan Province, Iran. Ali Reza Hosseininia , Maryam Vahabzadeh , Marziyeh Rashedinia , Bamdad Riahi-Zanjani,Karimi, G*. Mycotoxin Res. 2014 Feb;30(1):43-6.. Protective effects of glucosamine hydrochlorideagainst free radical-induced erythrocytes damage. Damage. Khadijeh Jamialahmadia,b, Omid Arastehc, Maryam Matbou Riahib,Soghra Mehrid, Bamdad Riahi-Zanjanie, Karimi, G*. Environmental toxicology and pharmacology 38 ( 2014 ) 212–219 Comparative Studies of Cytotoxic and Apoptotic Properties of Different Extracts and the Essential Oil of Lavandula angustifolia on Malignant and Normal Cells. Z Tayarani-Najaran , A Amiri , Karimi, G, SA Emami , J Asili, S H Mousavi. Nutrition and Cancer,2014 Apr;66(3):424-34 Cytotoxic and Apoptotic Potential of Rheum turkestanicum Janisch Root Extract on Human Cancer and Normal Cells. Shiezadeh F, Mousavi SH, Sadegh Amiri M, ranshahi M, Tayarani-Najaran Z and Karimi, G*. Iranian journal of pharmaceutical science . 2013: 12( 4), Autumn 2013, 811-819 Evaluation of anticonvulsant effect of two novels 4-[1-(4-fluorobenzyl)-5-imidazolyl] dihydropyridine derivatives in mice. Hadizadeh F., Rahimi B., Taghiabadi E. , Razavi M., Karimi G*. Research in Pharmaceutical Sciences, May 2013; 8(2): 91-95 Evaluation of in vitro toxicity of peptide 3 (N-acetyl-Leu-Gly-Leu-COOH)-substituted-β- 4 cyclodextrin derivative, a novel drug carrier, in 5 PC-12 cells. Sadeghnia et al. Hamid Reza Sadeghnia, Faezeh Vahdati Hassani, Hamid Sadeghian, Maryam Miandehi, Farzin Hadizadeh and Karimi, G* DARU Journal of Pharmaceutical Sciences 2013, 21:75 Preparation and Evaluation of Histamine Imprinted Polymer as a Selective Sorbent in Molecularly Imprinted Solid-Phase Extraction Coupled with High Performance Liquid Chromatography Analysis in Canned Fish. Sahebnasagh, A., Karimi, G. , Mohajeri, S. Food Analytical Methods , March 2013, Pages 1-8 Cytotoxic effects of crocin on MOLT-4 human leukemia cells. Ramin Rezaee, Mahmoud Mahmoudi, Khalil Abnous, Shahrzad Zamani, Taghizadeh Rabe, Nafiseh Tabasi, Mahmoud Hashemzaei and Karimi, G *. J Complement Integr Med. 2013; 10(1): 1–8 Protective Effect of Silymarin against Acrolein-InducedCardiotoxicity in Mice. Taghiabadi E, M Imenshahidi, Kh Abnous, F Mosafa, M Sankian,B Memar,6 and Karimi G*. Evidence-Based Complementary and Alternative Medicine. 2012;2012:352091. Tracheal responsiveness to methacholine and ovalbumin; and lung inflammation in guinea pigs exposed to inhaled lead after sensitization. HosseinBoskabady M , karimi G , Samarghandian S , Farkhondeh T. Ecotoxicology and Environmental Safety ,2012, 86 : 233–238 Comparison of Intralesional Two Percent Zinc Sulfate and Glucantime Injection in Treatment of Acute Cutaneous Leishmaniasis. Maleki M, Karimi G, Tafaghodi M, Raftari S, Nahidi Y. Indian Journal of Dermatology, 2012, 57;118-122.
Evaluation of nitric oxide or opioid receptors involvement in antinociceptive properties of silymarin1. Imenshahidi M 1, Rezaee R 2, MostofI A , Karimi G *. AJP, 2012 , 2:39-45 Determination of heavy metals in different honey brands from Iranian market, Akbari B , Gharanfoli F , Hassanzadeh Khayyat M, Khashyarmanesh Z, Rezaee R , Karimi G*. Food Additives and Contaminants ,2012 , 5: 1-7. Determination of parathion, aldicarb and thiobencarb in tap water and bottled mineral water in Mashhad , Iran. Rezaee R, Hassanzadeh-Khayyat M, Khashyarmanesh Z, Moallemzadeh Z, Mehri F, Karimi G*. Drug and Chemical Toxicology, 2012, 35:1-7. Determination of parathion, aldicarb and thiobencarb in tap water and bottled mineral water in northeast of Iran R. Rezaee, M. Hassanzadeh-Khayyat, Z. Khashyarmanesh, H. Moallemzadeh, F. Mehri, Karimi G* Drug Chem Toxicol, 2012 Apr;35(2):192-8 Mohajeri A, Karimi G, Aghamohammadian J, Rajabnia M J Applied Polymer Scie, 2011, 121: 3590-3595 Silymarinm a promising pharmacological agent for treatment of disease L Hosseinzadeh, J Behravan, F Mosaffa, Gh Bahrami, A Bahrami and Karimi G* Food and Chemical Toxicology. 2011, 49: 1102-1109 Evaluation of suppressive effect of paraquat on innate immunity in Balb\c mice. Riahi, B., Rafatpanah, H., Mahmoudi, M., Memar, B., Brook, A., Tabasi, N., Karimi G.* J Immunotoxicology, 2011, 8:39-45 Effect of curcumin on doxorubicin induced cytotoxicity in H9C2 cardiomyocyte cells. Hosseinzadeh L, Behravan J, Mosaffa F, Karimi G.* IJBMS, 2011, 14:49-56 Clozapine imprinted polymers: synthesis, ccharacterization and application for drug assay In human serum. Mohajeri A, karimi G, Rajabnia m. Analytica Chimica Acta, 2010, 683: 143-148 Antinociceptive effect of Elaeagnus angustifolia fruits on sciatic nerve ligated mice. Karimi G*, Hosseinzadeh h, Rassoulzadeh M, Razavi M, Taghiabadi E. IJBMS, 2010, 13: 97-101 Effects of Silymarin administration on TNF-α Serum concentration in peritoneal dialysis patients Nazemian F, Karimi G. Moatamedi M, Charkazi S, Shamsara J, Mohamadpoor A Phytotherapy Res, 2010, 24:1654-1657 Screening of acetylcholinesterase inhibitory activity of terpenoid and coumarin derivatives from the gens ferula Karimi G*, Iranshahi M, Hosseinzadeh F, Riahi B, Sahebkar A Pharmacologyonline, 2010, 1: 566-574 Protective Effects of Aqueous and Ethanolic Extracts of Portulaca oleraceae against cisplatin induced nephrotoxicity Karimi G*, Khoei A, Omidi A, Kalantari M, Babaei J, Taghiabadi E, Razavi M IJBMS, 2010, 13: 31-35. Evaluation of silymarin effect on granulose cell apoptosis and follicular development inpatients in patients undergoing IVF Moosavifar N, Mohammad poor A, Jalali M, Karimi G, Saberi H EMHJ, 2010, 16 (6), 460-463 Exposure assessment for mercury from consumption of marine fish in Iran Karimi G*, Moallem A, Hasanzadeh M, Bozorgi M, Nilli-Ahmadabadi A, Nazari F. Toxicological & Environmental Chemistry . 2010, 92: 1213-1218 Effects of atorvastatin on nitrate tolerance in diabetic rats Imenshahidi, M., Karimi, G., Kazemzadeh, E. Iranian Journal of Pharmaceutical Research. 2010, 9: 55-59
Immunotoxicity of paraquat after subacute exposure to mice Riahi, B., Rafatpanah, H., Mahmoudi, M., Memar, B., Brook, A., Tabasi, N., Karimi, G*.Food and Chemical Toxicology. 2010, 48: 1627-1631 Evaluation of the Analgesic Effect of Dextromethorphan and its Interaction With Nitric Oxide on Sciatic Nerve Ligated Rats Karimi, G*., Tabrizian, K., Rezaee, R. Journal of Acupuncture and Meridian Studies. 2010, 3: 38-42
Auraptene from Ferula szowitsiana protects human peripheral lymphocytes against oxidative stress Soltani, F., Mosaffa, F., Iranshahi, M., Karimi, G., Malekaneh, M., Haghighi, F., Behravan, J. Phytotherapy Research. 2010, 24: 85-89 In vitro evaluation of xanthine oxidase inhibitory activity of aqueous extracts of six medicinal plants Roobakhsh, A., Karimi, G*.Journal of Medicinal Plants. 2009, 8: 84-91+165 Persicasulphide C, a new sulphur-containing derivative from Ferula persica Iranshahi, M., Noroozi, S., Behravan, J., Karimi, G., Schneider, B. Natural Product Research .2009, 23: 1584-1588
Vasodilator effect of olive leaf aqueous extract and involvment of cyclooxygenase in the rat aorta Karimi, G.*, Imenshahidi, M., Jafarizaveh, E., Asgharian Rezaee, M. Pharmacologyonline. 2009, 2: 365-371
Evaluation of antigenotoxicity effects of umbelliprenin on human peripheral lymphocytes exposed to oxidative stress Soltani, F., Mosaffa, F., Iranshahi, M., Karimi, G., Malekaneh, M., Haghighi, F., Behravan, J. Cell Biology and Toxicology. 2009,25: 291-296
Antigenotoxic effects of the disulfide compound persicasulfide A (PSA) on rat lymphocytes exposed to oxidative stress Noroozi, S., Mosaffa, F., Soltani, F., Iranshahi, M., Karimi, G., Malekaneh, M., Haghighi, F., Behravan, J. Planta Medica. 2009,75::32-36
Contamination of patulin in clear apple juice in Mashhad, Iran Karimi, G*., Hassanzadeh, M., Yazdanpanah, H., Nazari, F., Iranshahi, M., Nili, A. Journal of Food Safety. 2008, 28: 413-421
Quantitative determination of methanol in plant water produced in Mashhad by spectrophotometry method Karimi, G*.., Hassanzadeh, M., Shahidi, N., Samie, Z. Journal of Medicinal Plants. 2008, 7:56-59
Evaluation of antidepressant effect of ethanolic and aqueous extracts of Silybum marianum L. seed in mice Karimi, G*., Saradeghi Keisari, M. Journal of Medicinal Plants. 2007, 6: 38-43
In vitro protective effects of Satureja hortensis L. essential oil and ethanolic extract on lymphocytes DNA Behravan, J., Mosaffa, F., Karimi, G. Iranshahi, M. Journal of Medicinal Plants. 2007, 6: 64-70
Protective effects of silymarin against free radical-induced erythrocyte lysis Karimi, G*., Hassanzadeh, M., Mehri, S. Journal of Complementary and Integrative Medicine. 2006, 3: article no. 8
The role of nitric oxide and protein kinase C in lipopolysaccharide- mediated vascular hyporeactivity Karimi, G*., Fatehi, Z., Gholamnejad, Z. Journal of Pharmacy and Pharmaceutical Sciences. 2006, 9: 119-123
Antigenotoxic effects of Satureja hortensis L. on rat lymphocytes exposed to oxidative stress Mosaffa, F., Behravan, J., Karimi, G., Iranshahi, M. Archives of Pharmacal Research. 2006, 29:159-164
Protective effects of lycopene and tomato extract against doxorubicin-induced cardiotoxicity Karimi, G*., Ramezani, M., Abdi, A. Phytotherapy Research. 2005, 19: 912-914
Cisplatin nephrotoxicity and protection by milk thistle extract in rats Karimi, G*., Ramezani, M., Tahoonian, Z. Evidence-based Complementary and Alternative Medicine. 2005, 2: 383-386
Anticonvulsant effect of Hypericum perforatum: Role of nitric oxide Hosseinzadeh, H., Karimi, G. Rakhshanizadeh, M. Journal of Ethnopharmacology. 2005, 98: 207-208
Evaluation of subacute toxicity of aqueous extract of Crocus sativus L. stigma and petal in rats Karimi, G*., Taiebi, N., Hosseinzadeh, Shirzad, F. Journal of Medicinal Plants. 2004, 3: 29-35
Antidepressant effects of Crocus sativus stigma extracts and its constituents, crocin and safranal, in mice Hosseinzadeh, H., Karimi, G., Niapoor, M. Journal of Medicinal Plants. 2004, 3: 48-58
Evaluation of the gastric antiulcerogenic effects of Portulaca oleracea L. extracts in mice Karimi, G*., Hosseinzadeh, H., Ettehad, N. Phytotherapy Research. 2004, 18: 484-487
Anticonvulsant effects of aqueous and ethanolic extracts of Hypericum perforatum L. in mice Hosseinzadeh, H., Karimi, G., Rakhshanizadeh, M. Journal of Medicinal Plants. 2004, 3: 23-30
Effects of Anethum graveolens L. seed extracts on experimental gastric irritation models in mice Hosseinzadeh, H., Karimi, G., Ameri, M. BMC Pharmacology. 2002, 2, art. no. 21
Effects of subacute lead acetate administration on nitric oxide and cyclooxygenase pathways in rat isolated aortic ring Karimi, G*., Khoshbaten, A., Abdollahi, M., Sharifzadeh, M., Namiranian, K., Dehpour, A.R. Pharmacological Research. 2002, 46: 31-37
Attempted suicide by insulin injection treated with hypertonic glucose solution Abdollahi, M., Jalali, N., Sharifzadeh, M., Karimi, G. Medical Journal of the Islamic Republic of Iran .1998, 12: 85-87
Book: 1- Karimi, G and R Rezaee. Perchlorate. 2014 Elsevier- Encyclopedia of Toxicology, Third Edition, 2014, 791–795 . 2- Karimi, G and P Lari, Tetrodotoxin . Elsevier .Encyclopedia of Toxicology, Third Edition, 2014, 515–518 3- Karimi, G and M Vahabzadeh, Thioxanthenes. Encyclopedia of Toxicology, Third Edition, 2014, 553–557 4- Karimi, G and M Vahabzadeh, Butyric Acid. Encyclopedia of Toxicology, Third Edition, 2014, 597–601 5- Karimi, G and M Rashedinia, Acrylamide. Encyclopedia of Toxicology, Third Edition, 2014, 69–73 6- Karimi, G and M Vahabzadeh, Killer Lakes. Encyclopedia of Toxicology, Third Edition, 2014, 40–42 Internal Congress: - Karimi G, Behravan J, Mosaffa F, Hosseinzadeh L, Bahrami G. Curcumin potentiates doxorubicin induced apoptosis in h cardiac muscle cells through generation of reactive oxygen spec.12 th Iranian congress of biochemistry & 4 th International congress of biochemistry and molecular biology.Mashhad ,Iran, 6-9 September, 2011. PP(357)
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