Date of Birth: 11th, September, 1979

Present Position:

Assistant Professor,

Avicenna Research Institute,

School of Pharmacy,

Mashhad University of Medical Sciences,

Mashhad, Iran

P. O. Box:  91775-1365, Mashhad, IRAN

Tel: +98-51-37112776

Fax: +98-51-37112470

E-mail:

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Education:

Research Interests:

1-Stem cell research

2-Tissue engineering

3-Cell therapy

4-Multi drug resistance in cancer

5-Evaluate the hypotheses considered in traditional iranian medicine

Professional Experience:

• 2011 to date: Assistant Professor of Pharmaceutical Biotechnology, Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
• 2011 to date: Supervisor of Biotechnology Department, Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
• 2011 to 2014: Education and Research Coordinator of Ph.D. by research students, Mashhad University of Medical Sciences, Mashhad, Iran

Teaching Experience:

Advanced cellular and Molecular Biology

International Publications:

1- Hashemi M., Kalalinia F.*, Application of encapsulation technology in stem cell therapy. Life Sciences. 2015, 143: 139–146. (IF: 2.702).

2- Karimi Sani I., Marashi SH., and Kalalinia F.*, Solamargine inhibits migration and invasion of human hepatocellular carcinoma cells through down-regulation of matrix metalloproteinases 2 and 9 expression and activity. Toxicology in Vitro. 2015, 29 (5): 893-900. (IF: 3.207).

3- Hosseini M., Nakhaei MM., Bayat M., and Kalalinia F., (1393). Antibiotic resistance pattern of metallo-beta-lactamase producing and non-producing clinical isolates of Pseudomonas aeruginosa in Mashhad, journal of north Khorasan University of medical science, 6(1): 33-40.

4- Kalalinia F., Elahian F., Mosaffa F., and Behravan J., Celecoxib up regulates the expression of drug efflux transporter ABCG2 in breast cancer cell lines. IJPR. 2014; 13 (4): 1391-99. (IF: 0.614)

5-Kalalinia F., Elahian F., Hassani M., Kasaeeian J.and Behravan J., Phorbol ester TPA modulates chemoresistance in drug sensitive breast cancer cell line MCF-7 by inducing expression of drug efflux transporter ABCG2. Asian Pac J Cancer Prev. 2012;13(6):2979-84. (IF: 1.33)

6- Mosaffa F, Kalalinia F, Lage H, Afshari JT, Behravan J. Pro-inflammatory cytokines interleukin-1 beta, interleukin 6, and tumor necrosis factor-alpha alter the expression and function of ABCG2 in cervix and gastric cancer cells. Mol Cell Biochem. 2012 Apr;363(1-2):385-93. (IF: 2.168)

7- Esmaeili B, Rezaee SA, Layegh P, Tavakkol Afshari J, Dye P, Ghayoor Karimiani E, Kalalinia F, Rafatpanah H. Expression of IL-17 and COX2 Gene in Peripheral Blood Leukocytes of Vitiligo Patients. Iran J Allergy Asthma Immunol. 2011 Jun; 10(2):81-9 (IF: 0.968)

8- Mosaffa F, Kalalinia F, Parhiz H, Behravan J. Tumor Necrosis Factor Alpha induces stronger cytotoxicity in ABCG2-overexpressing resistant breast cancer cells compared to their drug-sensitive parental line; DNA Cell Biol. 2011; 30(6):413-8 (IF: 2.28)

9- Hanafi-Bojd MY, Iranshahi M, Mosaffa F, Tehrani SO, Kalalinia F, Behravan J. Farnesiferol A from Ferula persica and Galbanic Acid from Ferula szowitsiana Inhibit P-Glycoprotein-Mediated Rhodamine Efflux in Breast Cancer Cell Lines. Planta Med. 2011; 77(14):1590-3 (IF: 2.369)

10-Amirghofran Z, Malek-hosseini S, Gholmoghaddam H, Kalalinia F. Inhibition of tumor cells growth and stimulation of lymphocytes by Euphorbia species. Immunopharmacol Immunotoxicol. 2011 Mar;33(1):34-42, (IF: 1.209).

11- Rassouli, F.B., Matin, M.M., Iranshahi, M., Bahrami, A.R., Behravan, J., Mollazadeh, S., Neshati, V., Kalalinia, F. (2010). Investigating the enhancement of cisplatin cytotoxicity on 5637 cells by combination with mogoltacin. Toxicol in vitro. 25 (2):469-74, (IF: 2.546).

12- Kalalinia, F., Elahian, F., Behravan, J. (2011). Potential role of cyclooxygenase-2 on the regulation of the drug efflux transporter ABCG2 in breast cancer cell lines. J. Canc. Res. Clin. Oncol. 137: 321-330, (IF: 2.485).

13-Elahian, F., Kalalinia, F.,Behravan, J.(2010). Evaluation of indomethacin and dexamethasone effects on BCRP mediated drug resistance in MCF-7 parental and resistant cell lines. Drug and Chemical Toxicol. 33 (2): 113-9, (IF: 1.25).

14-Elahian, F.;Kalalinia, F.;Behravan, J. (2009). Dexamethasone Downregulates BCRP mRNA and Protein Expression in Breast Cancer Cell lines. Onc. Res. 18 (1): 9-15, (IF: 1.299).

15- Kalalinia, F., Behravan, J.,Ramezani, M., Hassanzadeh, M. K., Asadipour, A. (2008). Chemical Composition, Moderate In Vitro Antibacterial and Antifungal Activity of the Essential Oil of Pistacia vera L. and it’s Major Constituents  Journal of Essential Oil Bearing plants.11 (4): 376 -383, (IF: 0.29).

Patents:

1. Hadizadeh F, Jouya M, Kalalinia F, Abnous K, Behravan J. Design, synthesis and effects of aromatase inhibitors with potential effects against breast cancer and pregnancy induced. Iran Patent 74795. 2012.
2. Hadizadeh F, Jouya M and Kalalinia F. In vitro measurement of potency of aromatase inhibitors using hepatic cancer cell lines (HepG2) and estrone ELISA kit. Iran Patent 79465. 2013.

Books:

1. Fatemeh Kalalinia, Fatemeh Mosaffa and Javad Behravan. Breast Cancer - Focusing Tumor Microenvironment, Stem cells and Metastasis, December 2011. Chapter 16: MCF-7 Breast Cancer Cell Line, a Model for the Study of the Association between Inflammation and ABCG2-Mediated Multi Drug Resistance. ISBN 978-953-307-766-6.

International Conference Presentations:

1-  Kalalinia F.*, Drugs and stem cells fate, Stem Cells and Regenerative Medicine International Congress- Mashhad, Iran, May 13-15, 2015.

2- Jamialahmadi Kh., Taheri M. and Kalalinia F., Pattern of Gankyrin Oncoprotein Expression in Drug Resistant and Sensitive Human Ovarian and Gastric Cancer Cell Lines, ASEAN Congress on Medical Biotechnology and Molecular Biosciences 2015.

3- Shirin Hamed Akbari Tusi, Hojjat Naderi-Meshkin, Mohammad Taghi Peyvandi, Fatemeh Kalalinia, Ahmad Reza Bahrami, Asieh Heirani-Tabasi, Mahdi Mirahmadi, Hossein HosseinKhani and Javad Behravan. Ream content or iliac crest: which one is the best source for producing mesenchymal stem cells? Stem Cells and Regenerative Medicine International Congress- Mashhad, Iran, May 13-15, 2015.

4- Shirin Hamed Akbari Tusi, Fatemeh Kalalinia, Hojjat Naderi-Meshkin, Hossein HosseinKhani, Mohammad Taghi Peyvandi, Ahmad Reza Bahrami, Asieh Heirani-Tabasi, Mahdi Mirahmadi and Javad Behravan. Collagen Reinforced by PGA Fibers as Scaffold for Bone Tissue Engineering. Stem Cells and Regenerative Medicine International Congress- Mashhad, Iran, May 13-15, 2015.

5- Kalalinia F.,Elahian F.,Behravan J. Induction of Cyclooxygenase-2 by Phorbol Ester TPA Modulate Chemoresistance by Induction Expression and Activity of Drug Efflux Transporter ABCG2 in Breast Cancer Cell Lines, CELL JOURNAL (YAKHTEH) Winter 2011; 12(Supplement 1 (The 1ST International Student Congress on Cell and Molecular Medicine)):49-50.

6-Fatemeh Mosaffa, Javad Behravan, Hermann Lage, Jalil Tavakol Afshari, Fatemeh Kalalinia. Pro-inflammatory cytokines alter the expression and function of ABCG2 in cervix and gastric cancer cell lines, but not in their drug resistant derivatives. Clinical Biochemistry Volume 44, Issue 13, Supplement, September 2011, Pages S68 (12th Iranian Congress of Biochemistry & 4th International Congress of Biochemistry and Molecular Biology, Mashhad, Iran, September 6-9 2011).

7- Kalalinia F.,Elahian F.,Behravan J. Induction of Cyclooxygenase-2 by Phorbol Ester TPA Modulate Chemoresistance by Induction Expression and Activity of Drug Efflux Transporter ABCG2 in Breast Cancer Cell Lines, CELL JOURNAL (YAKHTEH) Winter 2011; 12(Supplement 1 (The 1ST International Student Congress on Cell and Molecular Medicine)):49-50.

8- J Behravan, BF Kalalinia, M Ramazani, and A Asadipour. Evaluation of Antimicrobial Activity of the Essential Oil of the Gum of Pistacia Vera and its Major Components. Can J Infect Dis Med Microbiol. 2008 January; 19(1): 77–142.