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Leila Arabi Pharm.D., Ph.D. of Pharmaceutical Nanotechnology Assistant professor Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran P.O Box: 91775-1365 Email: این آدرس ایمیل توسط spambots حفاظت می شود. برای دیدن شما نیاز به جاوا اسکریپت دارید
EDUCATION: -Doctor of Philosophy (Ph.D.) (2009-2016) Pharmaceutical Nanotechnology School of Pharmacy, Mashhad University of Medical Sciences, Iran. -Doctor of Pharmacy (Pharm.D.) (2003-2009) School of Pharmacy, Mashhad University of Medical Sciences, Iran. -Visiting Research Scientist (2012-2013) Molecular Pathology department of the Institute for Pathology, University Hospital Basel-Switzerland -Visiting Scholar (2016-2017) Johns Hopkins University, University of California San Francisco, USA
RESEARCH INTERESTS AND EXPERIENCE: Targeted Drug Delivery, Liposomes, Targeting Tumor Cells and Microenvironment, Cancer Stem Cells, Non-Viral Vectors for Gene Delivery, Non-coding RNA, Cancer immunology
-Ph.D. thesis: “in vitro and in vivo targeted drug delivery to cancer stem cells isolated from murine colon carcinoma by doxorubicin nanoliposomes conjugated with monoclonal antibodies”, under supervision of Dr. Mahmoud Reza Jaafari, Dr. Ali Badiee, Dr. Fatemeh Mosaffa. (19.93/20) -Pharm.D. thesis: “Preparation and characterization of liposmes modified with lipopolymers constructed from polyethyleneimine and bromoalkane derivatives, as a non-viral gene transfer system” under supervision of Dr. Bizhan Malaekeh-nikouee and Dr. Mohammad Ramezani. (19.5/20). -Establishing a system for testing targeted and personalized medicines in malignant pleural effusions from cancer patients by using the xCelligence system (Roche Applied System) in collaboration with Roche Company.
TEACHING EXPERIENCES: Tumor Targeted Drug and Vaccine Delivery Systems, Nanoparticulate systems Characterization and Analysis, Biopharmaceutics and Pharmacokinetics, Cancer Biology, Tumor microenvironment, Cancer Immunology, Cancer stem cells, Pharmacy practice and Basic pharmacology.
PUBLICATIONS: Zanganeh S, Georgala P, Corbo C, Arabi L, .., Mahmoudi M. “Immunoengineering in glioblastoma imaging and therapy”, Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2019 Nov;11(6):e1575 Arabi L, Badiee A, Mosaffa F, JaafariMR.”Targeting CD44 expressing cancer cells with anti-CD44 monoclonal antibody improves cellular uptake and antitumor efficacy of liposomal doxorubicin”, J Control Release. 2015 Dec 28;220(Pt A):275-86 Quagliata L, Matter M, Piscuoglio S ,Arabi L, Ruiz C, Procino A, Kovac M, Moretti F, Makowska Z, Tornillo L, Diederich S, Heim M.H, CilloC and Terracciano L,”lncRNA HOTTIP/HOXA13 expression is associated with disease progression and predicts clinical outcome in HCC patients”, Hepatology. 2014 Mar;59(3):911-23 Ruiz C, Kustermann S, Pietilae E, Vlajnic T, Baschiera B, Arabi L, Lorber T, Oeggerli M, Savic S, Obermann E, Dirnhofer S, Singer T, Rothschild S, Zippelius A, Roth A, Bubendorf L. “Culture and drug profiling of patient derived malignant pleural effusions for personalized cancer medicine”, PLoS One. 2016 Aug 22;11(8) Andreozzi M, Quagliata L, Burmeister K, Arabi L, Schneider S, Tornillo L and Terracciano L, “DNA in situ Hybridizations for VEGFA Gene Locus (6p12) in Human Tumor Tissue”,Bio-Protocol, Aug 2015 Ruiz C, Vlajnic T, Arabi L, Wyttenbach S, Baschiera B, Rothschild S, Kustermann S, Zippelius A, Roth A, Bubendorf L, “Abstract 4681: The use of patient derived malignant effusions as in vitro models for a personalized healthcare-approach in anticancer therapy”, Cancer Research, AACR Annual Meeting; April 5-9, 2014; San Diego. Published Oct 2014. Arabi L, Gsponer J, Smida J, Nathrath M, Jundt G, Ruiz C, QuagliataL and BaumhoerD,”Upregulation of the miR-17-92 cluster and its two paraloga in osteosarcoma – reasons and consequences”, Genes Cancer. 2014 Apr;5(1-2):56-63. Yazdani M, Jalali SA, Badiee A, Shariat S, Mansourian M, Arabi L, Abbasi A, Saberi Z, Jaafari MR. "Stimulation of Tumor Specific Immunity by P5 HER-2/NeuGeneratedpeptide Encapsulated in Nano-Liposomes with High Phase Transition Temperature Phospholipids", Curr Drug Deliv. 2016 Jul 12. Alipour Talesh G, Ebrahimi Z, Badiee A, Mansourian M, Attar H, Arabi L, Jalali SA, Jaafari MR."Poly (I:C)-DOTAP cationic nanoliposome containing multi-epitope HER2-derived peptide promotes vaccine-elicited anti-tumor immunity in a murine model", Immunol Lett. 2016 Aug;176:57-64.
HONORS AND AWARDS: Selected as Communication chair of Immuno-Delivery Focus group at Controlled release Society (CRS) -2019 Selected as Ambassador in Young Scientist Committee (YSC) of Controlled release Society (CRS) -2019 Rank 1st in poster presentation in translational Nanomedicine, The European and Global Summit for Clinical Nanomedicine and targeted medicine, 2-5 September 2018 (11th CLINAM 2018) Basel- Switzerland Awarded top in teaching and education among the Pharmaceutical Nanotechnology Group 2019-Mashhad-Iran Highlights of Student Abstracts, 43rd Annual Meeting & Exposition of the Controlled Release Society (CRS), 2016, Seattle, Washington, USA Rank 1st in poster presentation, 14th Iranian Pharmaceutical Congress (IPSC2015) Dec 2015- Tehran-Iran Top Ph.D. student award in Research Festival of School of Pharmacy (Rank 2nd and 3rd), 2014 and 2015. Awarded Ph.D. student of the School of Pharmacy of the Mashhad University of Medical Sciences for the highest quality original publication of the year (2014-2015) Fellowship of CLINAM foundation for The European Summit for Clinical Nanomedicine 2015 (8th CLINAM 2015) Basel- Switzerland Fellowship of CLINAM foundation for The European Summit for Clinical Nanomedicine 2014 (7th CLINAM 2014) Basel- Switzerland Awarded Ph.D. student of the School of Pharmacy of the Mashhad University of Medical Sciences for the highest quality journal club presentation of the year (2013) Fellowship of CLINAM foundation for The European Summit for Clinical Nanomedicine 2013 (6th CLINAM 2013) Basel- Switzerland Rank 1st for poster presentation in Biovalley Life Science Week- 25th September, 2012, Basel- Switzerland Rank 1st among candidates, Iranian National “pharmaceutical Nanotechnology” Ph.D. comprehensive Exam based on examination and interview 2011 Rank 1st among candidates, Iranian National “pharmaceutical Nanotechnology” Ph.D. Entrance Exam based on entrance examination and interview 2008 Rank 1st among Ph.D. student of the School of Pharmacy of the Mashhad University of Medical Sciences based on overall scores (18.9 out of 20) Rank 2nd in Pharm.D. based on overall scores (18.05 out of 20) Top 1% Nationwide (Rank 4th in the country) in the comprehensive basic sciences exam of pharmacy students, 2006. Top 0.1% nationwide entrance exam of Iranian Universities
PRESENTATIONS AT SCIENTIFIC MEETINGS: ORAL PRESENTATIONS: Arabi L, Jaafari M.R, “Enhancement of Tumor Penetration and Efficacy of Liposomal Doxorubicin: What We Have Learned” Oral presentation, International Conference on Nanomedicine and Nanobiotechnology (ICONAN) 2019, Munich, Germany
Arabi L, Badiee A, Mosaffa F, Jaafari M.R, "Targeting EpCAM marker with monoclonal antibody improves cellular uptake and antitumor activity of liposomal doxorubicin”, Oral presentation, ILS/LRD Liposome Advances Conference,16-18 September 2017, Athens, Greece
Arabi L, Badiee A, Jaafari M.R, "Targeting Cancer stem Cells markers with monoclonal antibody improves cellular uptake and antitumor activity of liposomal doxorubicin”, Oral presentation, November 2016, UCSF (Prof. Szoka Lab), California, USA
Arabi L, Baschiera B, Wyttenbach S, Kustermann S, Ruiz C, Zippelius A, Roth A, Bubendorf L, “The use of patient derived malignant effusions as specific models for in-vitro assays for personalized cancer medicine”, Oral Presentation, 1st International Nastaran Cancer Symposium, October 1, 2015, Mashhad, Iran
Arabi L,Quagliata L, Rufle A, Terracciano L, Ruiz C and Baumhoer D. “Prognostic and therapeutic implications of the oncogenic miR-17-92 cluster in osteosarcoma”, Oral Presentation, The 1st Iranian Molecular Medicine Conference, March 2014, Mashhad University of Medical Sciences, Mashhad, Iran
Arabi L, Jaafari M.R.“ in vitro and in vivo Targeted Drug Delivery of Cancer Stem Cells Isolated from C26 Murine Colon Carcinoma Cell Line, by Doxorubicin Nanoliposomes Conjugated with CD44, CD133, EpCAM Monoclonal Antibodies” Oral Presentation, Dec 2012, Onco-Day, Department of Oncology, University Hospital Basel, Basel, Switzerland
Arabi L. Jaafari M.R. “Targeting Cancer Stem Cells with Nanoparticle-Enabled Therapies” Oral Presentation, Nov 2012, Research Festival, Institute for Molecular Pathology, University Hospital Basel, Switzerland
Arabi L. Jaafari M.R. “in vitro and in vivo Targeted Drug Delivery of Cancer Stem Cells by Doxorubicin Nanoliposomes Conjugated with Monoclonal Antibodies” Oral Presentation, Sep 2012, Institute for Molecular Pathology, University Hospital Basel, Basel, Switzerland
Arabi L, Malaekeh-Nikuei. B, Kazemi Oskuee. R, Dehshahri. A, Ramezani. M. “PolycationicNanoliposomes-Mediated Gene Transfer System Constructed from Polyethylenimines Modified with Bromoalkane and Acrylacte Derivatives” - Oral Presentation in English -5th International Controlled Release Conference of Iran (ICRC 2011)- October 2011- Mashhad- Iran
Arabi L, Malaekeh-Nikuei. B, Kazemi Oskuee. R, Dehshahri. A, Ramezani. M- “Nanoliposmes Modified with Lipopolymers Constructed from Polyethyleneimine (10 kDa) and Bromoalkane Derivatives Used for Gene Delivery; Preparation and Characterization and Transfection In Vitro”,Oral Presentation12th Iranian Pharmaceutical Sciences Congress (IPSC), Aug 2010, Zanjan, Iran.
POSTER PRESENTATIONS:
Arabi L, Badiee A, Mosaffa F, Jaafari M.R, “Improving Therapeutic Efficacy of PEGylated Liposomal Doxorubicin” Controlled Release Society Annual Meeting & Exposition, July 21-24, 2019, Valencia, Spain (Selected As Great Contribution To CRS)
Arabi L, Janani,M. Badiee A, Jaafari M.R, "Targeting The Mucin-1 Marker In Colon Carcinoma Improves The Therapeutic Efficacy Of Liposomal Doxorubicin ", The European and Global Summit for Clinical Nanomedicine and targeted medicine, 2-5 Sep 2018 (11th CLINAM 2018) Basel- Switzerland
Arabi L, Badiee A, Mosaffa F, Jaafari M.R, "Targeting CD133 Marker Improves Cellular Uptake And Antitumor Efficacy Of Liposomal Doxorubicin", NanoDDS’16 14th Annual Nanomedicine and Drug Delivery Symposium, Sept 2016, Johns Hopkins University, Baltimore, Maryland, USA Arabi L, Badiee A, Mosaffa F, Jaafari M.R. “Significant improvement of cellular uptake and antitumor activity of liposomal doxorubicin by targeting with anti-CD44 monoclonal antibody in mice bearing C-26 colon carcinoma”, Iranian Pharmaceutical Congress (IPSC2015)-December 2015-Tehran-Iran
Arabi L, Badiee A, Jaafari M.R., “Significant improvement of pharmacokinetic and therapeutic efficacy of liposomal doxorubicin by targeting the CD44 marker in colon carcinoma”, The European Summit for Clinical Nanomedicine (8th CLINAM 2015) , June 28-July 1,2015, Basel- Switzerland
Arabi L, Badiee A, Jaafari M.R., “Anti-CD44 antibody conjugated liposomal doxorubicin for targeting the cancer stem-like cells in mice bearing C26 colon carcinoma”- ANFC2015-March2015-Kish island-Iran
Arabi L, Badiee A, Mosaffa F, JaafariM.R. “Targeting the Cancer Stem Cells and Cancer Stem-like Cells Isolated from Cell Line by Liposomal Nanoparticles Conjugated with Monoclonal Antibodies” The European Summit for Clinical Nanomedicine (7th CLINAM 2014) , June 23-26,2014, Basel- Switzerland
Ruiz C, Vlajnic T, Arabi L, Wyttenbach S, Baschiera B, Rothschild S, Kustermann S, Zippelius A, Roth A, Bubendorf L, “Abstract Cancer Research: The use of patient derived malignant effusions as in vitro models for a personalized healthcare-approach in anticancer therapy”, AACR Annual Meeting, April 2014,San Diego, CA, USA
Arabi L, Badiee A, Jaafari M.R. “Isolation and Identification of Putative Cancer Stem Cells in C26 Murine Colon Carcinoma Cell Line”, The 5th Ph.D student Conference, March 2014, MUMS, Mashhad, Iran Arabi L, Badiee A, Mosaffa F, Jaafari M.R. “Isolation and Identification of Putative Cancer Stem Cells in C26 Murine Colon Carcinoma Cell Line”, The 1st Middle East Controlled Release Conference (MECRC 2014) and The 6th Iranian Controlled Release Society Conference (ICRC 2014), 25-27th February 2014, Tehran University of Medical Sciences, Tehran, Iran
Arabi L, Malaekeh-Nikuei. B, KazemiOskuee. R, Dehshahri. A, Ramezani. M. “Polycationic Nanoliposomes as DNA Nanocarriers with Low Toxicity: A Promising Gene Transfer System for Further in vivo Study”, The European Summit for Clinical Nanomedicine (6th CLINAM 2013) , June 23-26,2013, Basel- Switzerland
Arabi L, Baschiera B, Wyttenbach S, Kustermann S, Ruiz C, Zippelius A, Roth A, Bubendorf L.“The use of patient derived malignant effusions as specific models for in-vitro assays”, 5th Freiburg Symposium on Anticancer Drug Discovery, April 24 – 27, 2013, Freiburg, Germany
Arabi L, Quagliata L, Rufle A, Terracciano L, Ruiz C and Baumhoer D. “Prognostic and therapeutic implications of the oncogenic miR-17-92 cluster in osteosarcoma”, Non-coding RNA, epigenetics and transgenerational inheritance, April 2013, Churchill College in Cambridge University, Cambridge, UK
Quagliata L, Matter M, Arabi L, Piscuglio S, Makowska Z, Kovac M, Tornillo L, Heim M.H., Cillo C, Terracciano L, “HOTTIP Expression Levels Predict Patients’ Survival and Metastasis Formation In Hepatocellular Carcinoma” Charles RodolpheBrupbacher Symposium, January 30 - February 1, 2013, University Hospital Zurich, Zurich, Switzerland
Quagliata L, Matter M, Arabi L, Piscuglio S, Makowska Z, Kovac M, Tornillo L, Heim M.H., Cillo C, Terracciano L, “HOTTIP Expression Levels Predict Patients’ Survival and Metastasis Formation In Hepatocellular Carcinoma” Noncoding RNAs in Development and Cancer, January 20 - January 25, 2013, Vancouver, British Columbia, Canada
Arabi L, Stem Cells and Cancer. 7th International Heinrich F.C. Behr Symposium- October 14 - 16, 2012, German Cancer Research Center (Dkfz), Heidelberg, Germany
Arabi L, MalaekehNikuei. B, KazemiOskuee. R, Dehshahri. A, Ramezani. M- “Preparation, characterization and transfection efficiency of polycationicnanoliposomes as DNA nanocarriers with low toxicity“Biovalley Life Science Week- 25th September- 2012- Basel- Switzerland
Arabi L, Badiee.A, Mosaffa, F, Jaafari,M.R. “Cancer Stem Cells: Novel Targets of Anti-Cancer Treatments” -Poster Presentation-5th International Controlled Release Conference of Iran (ICRC 2011) - October 2011- Mashhad- Iran
Arabi L, Iranian Congress On Biology and Applications of Stem Cells, 27-29 April, 2011, Institute Of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran
Arabi L, Jaafari M.R. “Targeting Cancer Stem Cells and Their Microenvironmental Niche”- Poster Presentation- Research Festival- Avicenna Research Center, central lab, Mashhad University of Medical Sciences- December, 2011, Mashhad, Iran
Arabi L, Jaafari M.R. “Novel Cancer Therapies by Targeting Cancer Stem Cells and Their Microenvironmental Niche”, Poster Presentation, Symposium On Molecular Aspects of Cancer, Instituto of Biotechnology, Ferdowsi University of Mashhad, December, 2010, Mashhad, Iran Arabi L, Malaekeh-Nikuei. B, KazemiOskuee. R, Dehshahri. A, Ramezani. M. “Preparation and Characterization of Nanoliposmes Modified with Lipopolymers Constructed from Polyethyleneimine and Bromoalkane Derivatives”, Poster Presentation, 6th Nanotechnology Iranian Student Conference, 16-18 December 2009, Tehran, Iran
Arabi L, Malaekeh-Nikuei. B, KazemiOskuee. R, Dehshahri. A, Ramezani. M. “Preparation and Characterization of Nanoliposmes Modified with Lipopolymers Constructed from Polyethyleneimine and Bromoalkane Derivatives”, Congress on Nanomedicines, Nanobiotechnology, Nanobiosensors and Nanomaterials in Medicine Sciences, Jul 2009, Mashhad, Iran
PROFESSIONAL DEVELOPMENT: Manuscript Reviews: -Journal of Controlled Release -Iranian Journal of Basic Medical Sciences -Iranian Journal of Pharmaceutical Sciences -Immunologic Research -Experimental and Molecular Pathology -Journal of Drug Delivery Science and Technology -Nano Medicine Journal …
Membership in Professional Associations and Activities:
-Assistant Editor of Iranian Journal of Basic Medical Sciences (IJBMS) -Communication chair of Immuno-Delivery Focus group at Controlled release Society (CRS) - Member and Ambassador of Young Scientist committee of Controlled release Society (CRS) -Referee at Controlled release Society (CRS) -Member of Controlled release Society (CRS) -Member of “Nanotechnology Research Center”, Mashhad University of Medical Sciences -Student member of the European Society for Nanomedicine -Referee in Iranian Pharmacy Students Seminar (IPSS) -Member of scientific committee and referee in International controlled release conference of Iran -Member of scientific committee and referee in nanotechnology Iranian student conference -Member of scientific committee and referee in International controlled release conference of Medical Students of East of Iran -Member of Talented and Gifted students center, Mashhad University of Medical Science, pharmacy school, since 2002, Mashhad, Iran WORKSHOPS: -Workshop on “How to run a successful bio-nano-pharmaceutical consortial project?” By Dr. Barz, Johannes Gutenberg University -Workahop on”How to successfully start a bio-nano-pharmaceutical company”, Munich, Germany -Workshop on E-Learning- Mashhad University of Medical Sciences, 2019 -Workshop on mechanisms of drug interactions based on clinical findings, by Dr. Akhlaghi (University of Rhode Island, USA)- 5th November 2015, Mashhad-Iran -Virtual workshop for training Referee, 19th Iranian Pharmacy Students Seminar (IPSS19)-March 2015 -Patent Registration, BuAli research Center, 4th August 2015- Mashhad-Iran -Pathway to publication workshop- Mashhad University of Medical Sciences-Nov 2014- Mashhad-Iran -Nanocarrier workshop by Prof. Theresa Allen (University of Alberta) -ANFC2015-Kish island-Iran -Tissue engineering, Tehran University of Medical Sciences, Feb 2014, Iran -Business Planning Workshop- Tarbiyat Modarres university-26 February 2014- Tehran-Iran -Cytation 3 Cell Imaging Multi-Mode Reader workshop- BuAli Research center- December 2014-Iran -Stem Cell Research in Academia and Industry, 23st BD-STCS Workshop, Oct 2012, Basel, Switzerland. -PCR-RFLP (restriction fragment length polymorphism), May 2012, BuAli Research Center, Medical genetics group, Medical School, Mashhad, Iran -Flow Cytometry and Cell Isolation Methods (MACS and FACS), 2011, Rouyan Inistitute, Tehran, Iran. -Patent Registration, 5th International Controlled Release Conference of Iran (ICRC 2011) –Oct 2011- Mashhad- Iran. -Principle of Flow Cytometry and Its Applications, Avicenna Research Center, Central Lab, Mashhad University of Medical Sciences, 13 July 2011, Mashhad, Iran. -Application of Nanotechnology in Medicine and Engineering, Professor Mansouri, Ferdowsi University Of Mashhad., Mashhad, Iran. -Treatment of Isolated Mesenchymal Stem Cells from Bone Marrow, Cord Blood and Adipose Tissue or Cell Therapy, 25-26 April 2011, Iranian Congress On Biology and Applications of Stem Cells, Ferdowsi University of Mashhad, Mashhad, Iran. -Preparation and Characterization of Nanogel, 12th Iranian Pharmaceutical Sciences Congress (IPSC 2010), 4 August 2010, Zanjan, Iran. -Scientific Articles Writing and Publishing Methods- 6th Nanotechnology Iranian Student Conference, 16-18 December 2009, Tehran, Iran. -Microsoft Office Programs (Outlook, April 2011- Excel, August 2010 -Onenote, September 2010- Powerpoint, 2010) Mashhad University of Medical Science, Pharmacy School, Mashhad, Iran. -Reference Management (Endnote & Reference Manager) 2009, Sept 2009, Mashhad University of Medical Science, Pharmacy School, Mashhad, Iran. -SPSS Data Analysis, September 2009, Mashhad University of Medical Science, Pharmacy School, Iran. -Electronic Resources and Databases, 2008, Student Research Committee, MUMS, Mashhad, Iran. -Herbal Medicine, 2008, Student Research Committee, MUMS, School of Medicine, Mashhad, Iran. -Traditional Medicine, 2008, Student Research Committee, MUMS, Mashhad, Iran. -Principles of Astronomy, January 2007, Ferdowsi University of Mashhad, Faculty of Science, Iran. -Introduction to Nanobiotechnology, Jul 2007, Student Research Committee, MUMS, Mashhad, Iran. -Introduction to Research and Research Methodology, 2006, Student Research Committee, MUMS, Iran
LANGUAGE: Native speaker in Persian, Fluent in English, Intermediate Proficiency in Arabic, A1 level in German
REFERENCE: Prof. Mahmoud Reza Jaafari, Nanotechnology department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran, این آدرس ایمیل توسط spambots حفاظت می شود. برای دیدن شما نیاز به جاوا اسکریپت دارید Prof. Luigi Terracciano, Molecular Pathology Division, Institute of Pathology, University Hospital Basel, Switzerland, این آدرس ایمیل توسط spambots حفاظت می شود. برای دیدن شما نیاز به جاوا اسکریپت دارید Prof. Theresa M. Allen, Professor Emeritus, Dept. of Pharmacology, University of Alberta Adjunct Professor, Dept. of Biochemistry &Molecular Biology, University of British Columbia, این آدرس ایمیل توسط spambots حفاظت می شود. برای دیدن شما نیاز به جاوا اسکریپت دارید
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