Research and Academic Experiences:

 

Teaching Experiences:          Biopharmacy and Pharmacokinetics Courses to

                                                      Pharm. D., MSc (Toxicology),  and Ph. D.

                                                      Students.(Pharmaceutics, Biotechnology and Pharmacology

                                                      Ph. D. Students)

                                                Instrumental Methods of Analysis Courses to

                                                      Pharm. D., MSc (Toxicology), Ph. D.

                                                      (Pharmaceutics, Drug controls and Pharmaceutical

                                                       Chemistry) Students and also to Medical

                                                Physics Ph. D. Students.

                                                Quality Control Courses to Ph. D. (Pharmaceutics, Drug

                                                       controls) Students.

                                               

 

Research Intrests:                            

-Drug bioavailability and bioequvalency.

 -Various aspects of drug analysis in vivo.

-Drug analysis (TDM) and stability of drugs in vivo.                                      

 -Drug analysis and stability of drugs in vitro.                                                    

-Quantitative and qualitative evaluations of  essentiol oils in various medicinal plants.

- Evaluation of regional medicinal plants antioxidant activity.

-Quantitative and qualitative evaluations of Pesticides in food materials.

-Quantitative and qualitative evaluations of  mycotoxins contamination in food materials.

- Research in the area of Analytical Forensic Toxicology.

 

Seminars & Congresses:

 

                                    Taking part with presentation in more than 60

                                    different international  and national congresses

                                    and seminars in Iran and other countries.

 

Supervising Thesis

 

1982--present             Supervise and consultant of more than 15 different thesis of Ph.D. and

                                    MSc as well as supervising more than 80 different thesis of Pharm. D.

                                    students.

 

 

Some of the Research  projects Carried out at the school of Pharmacy Mashhad University of Medical Sciences (MUMS)

1- A computer program for calculating pharmacokinetics parameters.

2- Bioequvalency of different dosage forms of ampicillin in Iranian market.

3-Relative bioavailability of different brands of cephalexin capsules.

4- Comparative bioavailability studies of some oral amoxycillin capsules.

5-Acetylation phenotyping using isoniazid in  Korasanian population.

6-Bioavailability study of four different oral formulation of cephradine capsules.

7- Phytochmical and antimicrobial studies of Iranian Conifers.

8- Study methods of bleaching beeswax.

9- Determination  of  Flouride in different kinds of domestic toothpastes and comparison with various foreign made commercial brands and international standards.

10- Determination of nicotine in differsent international and national kinds of cigaretts, cigar and tobacco.

11- Quantitative evaluation fluoride ion from different sodium fluoride tablet formulations in children.

12- Analysis of the Mentha piperita and Mentha pulegium essential oils and  evaluation of their clinical effects on nasea and vomiting after  chemotherapy.

13- Evaluation of antigout effect of some Iranian medicinal plants via xanthine oxidase activity inhibition and comparison with allopurinol.

14- Evaluation of urinary fluoride ion excretion  after usig sodium fluoride mouthwash by children (7-11 year old ) and comparison with various foreign made commercial brands and international standards.

15- Study of preparation and purification of the anticancer, Taxul, from Taxus Baccata L. using tissue culture method.

16- Phytochemical study of trestrial plants of Hashilan wetland (Kermanshah province).

17- Phytochemical study of aquatic plants of Hashilan wetland(Kermanshah province).

18- Quantitative and qualitative studies on different cultivars of saffron in Iran.

 19-     The Antioxidant Activity of the Essential Olis of Iranian Cupressus semipervirens L. var. horizentaliss, Cupressus semipervirens L. var. cereinformis and Cupressus semipervirens L. var. fastigigiata DC.

20- The antioxidant activity of the methanolic extracts of Iranian commonConifers.

21- The Antioxidant Activity of the Essential Oils of Iranian Juniperus foetidissima and  Juniperus sabina..

22-  Evaluation of Antioxidant Activity of the Essential Oils of Iranian Platycladus Orientalis  and Pinus halpenisis using several quick and simple methods.

 23- Evaluation of the genetic diversity and composition of essential oil of Iranian conifer spp. Based on RAPD and GCMS analysis

24- Inter individual Variability of Coumarin 7- hydroxylation in an Iranian population (Khorasan).

25- The Antioxidant Activity of the Essential Olis of Iranian Juniperus exelsa and Juniperus polycarpos..

26- Extraction and structure elucidation of waxes in different species of  Iranian conifers.

27- The Antioxidant Activity of the Essential Olis of Iranion  Juniperus Oblonga and Juniperus ommunis subsp.hemispherica.

28- Determination of Aflatoxin M₁ in pasteurizodn Milk samples in Mashhad.

29- Determination of heavy metals (Al, Pb, Cu, As) in dry and infusion black tea samples available in mashhad.

30- Comparison of sodium valproate clearance between epileptic patients and patients with acute mania.

31- Determination of mycotoxin patulin in apple juice produced in Mashhad.

32- Effects of pentoxyfylline on erythropoietin resistant anemia and Serum level of TNF- a and INF-g in renal failure patients.            

33- Qualitative and quantitative determination of the volatile and aromatic  compounds in various kind of traditional peppermint hydrola available in the Mashhad market.

34- Evaluation of antioxidant activity of methanol extracts of various kind of Artemisia (growing in Khorasan).

35- Evalution  of enzymatic GSTs Genes polymorphisms and it's association with  P16 methylation in Esophageal cancer patients.

 36- Qualitative and Quantitative determination of monomer migration of polymeric containers in drink water packaging.

37- The Antioxidant Activity of the Essential Oils of different parts of Juniperus communis subsp.hemisphaerica in lipid system

 39-  Evaluation of Gancyclovir effect on mycophenolate mofetile clearance in kidney transplant patients.

40- Pharmacokinetic monitoring of vancomycin and evaluation of the affecting factors on vancomycin pharmarmacokinetics in hemodialysis patients.

41- The antioxidant activity of the essential oils and different extractions ofSatureja horttensis and Artemisia dracunculus.

42- Evaluation of the genetic diversity and composition of essential oil of Iranian Ephedra spp. based on RAPD and GC-MS analysis.

43- Antioxidant activity of Iranian Cupressaceae essential oils in two different lipid systems.

44-  Exposure assessment for mercury from consumption of marine fish in Iran.

45- Determination of Aldicarb, Bentazone, Molinate, Thiobencarb and Parathion in  Mashhad pipe water and comparison with packed mineral water available in the markets.

46- Determination of Trace Heavy Metals Levels in Honey Samples from Mashhad city.

47- Extraction, purification and structure elucidation of sesquiterpene coumarins  from the roots of Ferula flabelliloba and characterization of volatile  components of the fruits by GC/MS.

48- Evaluation of gold nanoparticles effectiveness in sonodynamic and photothermal therapies in a Carcinoma tumor model (CT26).

49- DETERMINE NUTRITIONAL STATUS AND THE EFFECT OF ZINC SUPPLEMENTATION ON GROWTH AND BONE HEALTH IN PAEDIATRIC  PATIENTS WITH THALASSEMIA.

50- Internal evaluation of medicinal chemistry group in Mashhad school of Pharmacy.

51- The antioxidant activity of the essential oils and different extractions of Satureja horttensis and Artemisia dracunculus.

52- Nutritional Status and Bone Health in Pediatric Patients with  Transfusion-dependant β Thalassemia.

53- Evaluation of Antioxidant effects of various fractions from aerial part  of 3 species of Artemisia.

54- Study of binding pattern of G-CSF to proteins of Brain of mice.

56- Analyze of polymorphisms of paraoxonase,coagulation factor 13,platelet  glycoprotein IIb,β2 adrenergic receptor and angiotensin II receptor genes in  patients with stroke problem.

57- Extraction and analysis of diazinon in cucumber using its molecularly imprinte Polymer.

58- Determination and comparison of heavy metal in various kind of Iranian and imported Rice

59- A study on bleaching occurrence of Protoporphyrin IX as a sonosensitizer during ultrasound irradiation

60- Extraction and analysis of diazinon in tomato using its molecularly imprinted Polymer

61- Evaluation of antioxidant and anti-melanogenic activity of different extracts of aerial parts of various Salvia species by preventing tyrosinase activity in murine  melanoma B16F10 cells

62- Evaluation of Characteristics of human growth hormone upon site specific PEGylation

63- Preparation of an apta-sensor for identification and quantification of Sirulimus

64- Synthesis and characterization of composite polymer, polyethyleneglycol grafted  flower-like cupric nano oxide for solid phasemicroextraction of ultra-trace levels of benzene, toluene, ethylbenzene and o-xylene in human hair and water samples.

65- Photo Catalytic Degradation of Linear Alkylbenzene Sulfonic Acid

66- An electrochemical aptasensor for kanamycin detection based on complimentary strand

67-A study on bleaching occurrence of Protoporphyrin IX as a  sonosensitizer during ultrasound irradiation.

68- Determination and comparison of heavy metal in various kind of  Iranian and imported Rice.

69- Quantitative evaluation of Pastorized milk contamination to  aflatoxine M₁ in city of Mashhad.

70- Evaluation of Antioxidant effects of various fractions from aerial parts of four species of Artemisia

71- Evaluation of Characteristics of human growth hormone upon site specific PEGylation.

72- Encapsulation of berberine in Saccharomyces cerevisiae as a novel drug carrier and analysis of microcapsules as natural  preservative system in food and pharmaceutical industries.

73- Evaluation of Antioxidant effects of various fractions from aerial parts of four species of Artemisia

74- Determination of 13 pesticides  residues  in tomato paste sample from  Mashhad’s factory using GC/MS methods.

75- Determination of ethanol and methanol in commonly used brands of  low alcohol beer in Iran.

76- Inhibition of Xanthine Oxidase by Some Iranian Plant Remedie Used for Gout.

77- Serial measurement of TGF-b₁, IL-8 in serum of patients with Ischemic stroke and evaluation of their correlation with severity and outcome.

78- Evaluation of neopterin serum concentration as an independent cardiovascular biomarker in coronary artery disease.

79- Development of an aptamer-based biosensor for rapid and sensitive  detection of residual streptomycin in milk

80- Generation of aptasensor for Morphine.

81- Correlation between serum concentrations of some micronutrients  and severity of coronary slow flow in patients with coronary slow flow