محسن ايمن شهيدي

استاد فارماكولوژي

دانشكده داروسازي، دانشگاه علوم پزشكي مشهد

مشهد – ايران

صندوق پستي: 1365- 91775

تلفن: 66-8823255-511-98+

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دكتراي داروسازي (Pharm. D.) : دانشكده داروسازي، دانشگاه علوم پزشكي مشهد (1376-1371).

دكتراي تخصصي (Ph. D.) فارماكولوژي: دانشكده پزشكي، دانشگاه علوم پزشكي مشهد (1383-1376).

دوره تكميلي تحقيقاتي: موسسه تحقيقاتي قلب، دانشگاه اتاوا، كانادا.

عنوان پايان نامه Ph. D. : بررسي اثر لواستاتين بر اتساع عروقي وابسته و غير وابسته به اندوتليوم در رت ديابتي.

گرايش تحقيقاتي

- فارماكولوژي قلب و عروق با استفاده از مدل آئورت جدا شده و بستر عروقي مزانتر.

- فارماكولوژي CNS و رفتاري

همایش ها

1- Mohsen imenshahidi . Effect of extracellular calcium depletion on atrial natriuretic factor secretion and gene expression. 2005 ^17th Iranian Congress of Physiology and Pharmacology.

3-Mohsen imenshahidi, Golamreza Karimi, Jafari Zaveh Evaluation of the effect of olive leaf decoction on rat blood pressure and vasorelaxation of rat isolated aorta and its mechanism(s). 2006. ^10th Iranian Congress of Pharmaceutical Sciences.

4-Mohsen imenshahidi, Golamreza Karimi, Ehsan Kazemzadeh Effects of Atorvastatin on Nitrate Tolerance in Diabetic Rats. 2007.  ^18th Iranian Congress of Physiology and Pharmacology.

5-Mohsen imenshahidi, Hossein Hosseinzadeh, Yaser Javadpour. Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin in normotensive and hypertensive rats. 2009 . International congress of saffron.

6- Mohsen imenshahidi, Hossein Hosseinzadeh, Hamidreza Zafari. Effects of crocin on the acquisition and reinstatement of morphine-induced conditioned place preference in mice. 2009. International congress of saffron.

7-  Mohsen Imenshahidi; Hossein Hossenzadeh; Marjan Razavi. Characterization of the hypotensive mechanism of the aqueous extract of Crocus sativus stigma and its two constituents, crocin and safranal, in rat. 2012 ^12th Iranian Congress of Pharmaceutical Sciences.

مقالات منتشر شده

1- Imen shahidi, M., Fatehi, Z., Parsaie, H. 2004. Effect of lovastatin on acetylcholine induced relaxation in the isolated mesenteric bed  of streptozotocin diabetic rats. Iranian Journal of Basic Medical Sciences; 7(2): 58-64.

2- Fatehi-Hassanabad, Z., Fatehi, M., Iman Shahidi, M. 2004. Endothelial dysfunction in aortic rings and mesenteric beds isolated from desoxycorticosterone acetate hypertensive rats: Possible involvement of protein kinase C. Eur J Pharmacol; 494: 199-204.

3-  Fatehi, M., Fatehi-Hassanabad, Z., Imen shahidi, M., Razavi-Tossi, M. 2004. Effects of protein kinase C inhibitor on the responses to the vasodilator agents in the isolated aorta and mesenteric bed from hypertensive rats. Iranian Journal of Basic Medical Sciences; 6(4): 307-314. 

4- Khooei, A.R., Hosseinzadeh, H., Iman Shahidi, M. 2002. Pathologic Evaluation of anti-ischemic effect of Salvia Lerrifolia Benth. Seed and leaf extracts in rats after global cerebral ischemia. Iranian Journal of Basic Medical Sciences; 4(2): 234-239.

5- Iman Shahidi, M., Hosseinzadeh, H. 2002. Animal models of diabetes. Iranian Journal of Diabetes and Lipid; 2(1): 1-10. 

6- Hosseinzadeh, H., Iman Shahidi, M. 1999. Effect of Salvia Lerrifolia Benth. Seed and leaf extracts on Survival time in hypoxic mice. Iranian Journal of Basic Medical Sciences; 2(2): 75-81.

7-Fatehi-Hassanabad Z, Imen-Shahidi M, Fatehi M, Farrokhfall K, Parsaeei H. 2006. The beneficial in vitro effects of lovastatin and chelerythrine on relaxatory response to acetylcholine in the perfused mesentric bed isolated from diabetic rats. Eur J Pharmacol. 535(1-3): 228-33. 

8-Mohsen Imanshahidi and Hossein Hosseinzadeh. 2006. The Pharmacological Effects of Salvia species on the Central Nervous System. Phytother. Res. 20(6): 427-37.

9- Mohsen Imanshahid.  Effect of ExtracellularCalcium Depletion on Atrial Natriuretic FactorSecretion and Gene Expression. Iranian Journal of Pharmaceutical Sciences. Winter 2006: 2(1): 23-30.

10-  Heydar Parsaee, Mohsen Imenshahidi, Zahra Fatehi. 2006. Lovastatin incubation improves acetylcholine-induced relaxation in isolated aortic rings of diabetic rat. IJPR. 3: 191-198.

11- Mohsen Imenshahidi, Hossein Hosseinzadeh, Ali Es'haghian. 2007. EFFETS OF ETHOSUXIMIDE ON MORPHINE TOLERANCE AND DEPENDENCE IN MICE. Pharmacologyonline 2: 287-299.

12- Mohsen Imanshahidi, Hossein Hosseinzadeh. Pharmacological and Therapeutic Effects of Berberis vulgaris and its Active Constituent, Berberine. Phytother. Res. 22, 999–1012 (2008).

13- Farzin Hadizadeh, Mohsen Imenshahidi, Fatemeh Mohammadpour, Pooya Mihanparast  and Mahmoud Seifi. SYNTHESIS AND CALCIUM CHANNEL ANTAGONIST ACTIVITY OF 4-[(HALOBENZYL)IMIDAZOLYL]  DIHYDROPYRIDINES. Saudi Pharmaceutical Journal, Vol. 17, No. 2 April 2009, 170-176.

14- Hossein Hosseinzadeh,  Hamid Reza Sadeghnia,  Mohsen Imenshahidi,  Bibi Sedigheh Fazly Bazzaz. Review of the Pharmacological and Toxicological Effects of Salvia leriifolia. Iranian Journal of Basic Medical Sciences Vol. 12, No. 1, Spring 2009, 1-8. 

15- Karimi G, ImenshahidiM, Jafarizaveh E, Asgharian Rezaee M. VASODILATOR EFFECT OF OLIVE LEAF AQUEOUS EXTRACT AND IVOLVMET OF CYCLOOXYGEASE I THE RAT AORTA. Pharmacologyonline 2: 365-371 (2009)

16- Farzin Hadizadeh, Mohsen Imenshahidi, Payman Esmaili, Morteza Taghiabadi. Synthesis and Effects of Novel Dihydropyridines as Dual Calcium Channel Blocker and Angiotensin Antagonist on Isolated Rat Aorta. Iranian Journal of Basic Medical Sciences.  13, 2010, 195-201.

17- Imenshahidi M, Hosseinzadeh H, Javadpour Y. Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats. Phytother Res 2010 Jul;24(7):990-4

18- Imenshahidi M, Karimi GH, Kazemzadeh E. Effects of Atorvastatin on Nitrate Tolerance in Diabetic Rats. IJPR. 2010; 9(1), 55-59.

19- Mohsen Imenshahidia, Farzin Hadizadeha,b*, Asieh Firoozeh-Moghadama, Mahmoud Seifia, Atefeh Shirinbaka and Mohammad Bagher Gharedaghia. Synthesis and vasorelaxtion properties of 9-aryl- 1,8-acridinediones as potassium channel openers in isolated rat aorta. Iranian Journal of Pharmaceutical Research (2012), 11 (1): 229-233

20- Mohammad Reza Saberi, *²Farzin Hadizadeh, ¹Mohsen Imenshahidi, ²Hadi Shakeri, ²Seyedeh Toktam Ziaee, ¹Mohammad Ali Ghafuri, ¹Ramin Sakhtianchi, ¹Zohreh Badieyan, ¹Somieh Hajian. Synthesis and Effects of 4,5-Diaryl-2-(2-alkylthio-5-imidazolyl) Imidazoles as Selective Cyclooxygenase Inhibitors. Iranian Journal of Basic Medical Sciences Vol. 13, No. 4, Autumn 2010, 207-212

21- Imenshahidi, M., Zafari, H. and Hosseinzadeh, H. (2011). Effect of crocin on the acquisition and reinstatement of morphine-induced conditioned place preference in mice. Pharmacologyonline 1: 1007-1013.

22- Mohamadpour AH, Moallem SA, Hashemzaei M, Abnous K, Tabatabaee Yazdi SA, Imenshahidi M. Effects of granulocyte colony-stimulating factor on electrocardiogram changes after carbon monoxide poisoning in rats. Drug Chem Toxicol. 2012 Oct;35(4):353-60.

23- Mohsen Imenshahidi1, Ramin Rezaee2, Amin Mostofi2 , Gholamreza Karimi2*Evaluation of nitric oxide or opioid receptors involvement in antinociceptive properties of silymarin Avicenna Journal of Phytomedicine Received: Sep 26, 2011; Accepted: Nov 6, 2011

24- Hosseinzadeh H, Imenshahidi M, Hosseini M, Razavi BM. Effect of Linalool on Morphine Tolerance and Dependence in Mice. Phytother Res. 2012 Sep;26(9):1399-404.

25- Hossein Hosseinzadeh, Mohsen Imenshahidi, Alireza Arasteh.  Effects of aqueous saffron extract (Crocus sativus L.) on the acquisition and reinstatement of morphine-induced conditioned place preference in mice. Avicenna Journal of Phytomedicin e Vol. 2, No. 1, Winter 2012, 24-30 

26- . Mohsen Imenshahidi1, Mohammad Eghbal1, Amirhossein Sahebkar2, Mehrdad Iranshahi2* Hypotensive activity of auraptene, a monoterpene coumarin from Citrus spp. Pharm Biol. 2013 May;51(5):545-9

27- Mitra Asgharian Rezaeea, Seyed Adel Moallema,b,d, Mohsen Imenshahidia, Mahdi Farzadniac and Amir Hooshang Mohammadpoura, Effects of Erythropoietin on Electrocardiogram Changes in Carbon Monoxide Poisoning: an Experimental Study in Rats. Iranian Journal of Pharmaceutical Research (2012), 11 (4): 1191-1199

28- Elahe Taghiabadi,¹ Mohsen Imenshahidi,² Khalil Abnous,³ Fatemeh  Mosafa,⁴ Mojtaba Sankian,⁵ Bahram Memar,⁶ and Gholamreza Karimi^7. Protective Effect of Silymarin against Acrolein-Induced Cardiotoxicity in Mice. Evidence-Based Complementary and Alternative Medicine Volume 2012 (2012), Article ID 352091, 14 pages

29- Marjan Razavi1, Hossein Hosseinzadeh2, Khalil Abnous3, Vahideh Sadat Motamedshariaty4, Mohsen Imenshahidi*. Crocin Restores Hypotensive Effect of Subchronic Administration of Diazinon in Rats. Iranian Journal of Basic Medical Sciences. Volume 16, Number 1, January 2013, Page 64-72.

30- Razavi BM, Hosseinzadeh H, Movassaghi AR, Imenshahidi M, Abnous K. Protective effect of crocin on diazinon induced cardiotoxicity in rats in subchronic exposure. Chem Biol Interact. Chemico-Biological Interactions 203 (2013) 547–555.

31- Maryam Hassanpour Moghadam, Mohsen Imenshahidi, and Seyed Ahmad Mohajeri Antihypertensive Effect of Celery Seed on Rat Blood Pressure in Chronic Administration J Med Food 16 (6) 2013, 558–563

32- Mohsen Imenshahidi, Bibi Marjan Razavi, Ayyoob Faal, Ali Gholampoor, Seyed Mehran Mousavi, Hossein Hosseinzadeh. (2013). The effect of chronic administration of saffron (Crocus sativus) stigma aqueous extract on systolic blood pressure in rats. Jundishapur J Nat Pharmac Prod 8 ( 4 ) pp. 175 - 179

33- Mohsen Imenshahidi, Bibi Marjan Razavi, Ayyoob Faal, Ali Gholampoor, Seyed Mehran Mousavi, Hossein Hosseinzadeh. (2013). The effect of chronic administration of safranal on systolic blood pressure in rats. ranian Journal of Pharmaceutical Research (2015), 14 (2):

34- Seyed Adel Moallem^1,3, Mohsen Imenshahidi¹, Narges Shahini¹,  Ahmad Reza Javan¹, Mohsen Karimi¹, Mona Alibolandi², Morteza Ghandadi¹,  Leila Etemad¹, Vahidehsadat Motamedshariaty⁴ , Farzin Hadizadeh^1,2* Synthesis, anti-inflammatory and anti- nociceptive activities and in vitro antitumor effect of novel thiazolidin 4-ones derivatives as selective cyclooxygenase (COX-2) inhibitors Iran J Basic Med Sci. Dec 2013; 16(12): 1238–1244

35^- Mohsen Imenshahidi¹, Reza Qaredashi², Mahmoud Hashemzaei³ and Hossein Hosseinzadeh⁴   2014  Inhibitory effect of Berberis vulgaris aqueous extract on acquisition and reinstatement effects of morphine in conditioned place preferences (CPP) in mice Jundishapur J Nat Pharm Prod. 2014 Jun 16;9(3):e16145. eCollection 2014 Aug

36- Ghazanfari S, Imenshahidi M, Etemad L, Moshiri M, Hosseinzadeh H. Effect of Cyanocobalamin (vitamin B12) in the Induction and Expression of Morphine Tolerance and Dependence in Mice.Drug Res (Stuttg). 2013 Oct 8. [Epub ahead of print]

37- Lari P, Abnous K, Imenshahidi M, Rashedinia M, Razavi M, Hosseinzadeh H.Evaluation of diazinon-induced hepatotoxicity and protective effects of crocin. Toxicol Ind Health. 2013 Feb 13. [Epub ahead of print]

38- Razavi BM¹, Hosseinzadeh H, Abnous K, Imenshahidi M. Protective effect of crocin on diazinon induced vascular toxicity in subchronic exposure in rat aorta ex-vivo. Drug Chem Toxicol. 2014 Jan 7. [Epub ahead of print]

39- Moein Rashidifar1, Mohsen Imenshahidi1, Neda Rahmani-Fazli2 and Farzin Hadizadeh2*.  Synthesis and evaluating cardiac effects of 3,4-dihydropyrimidin-2-one-5-carboxylates in isolated atria of animal model. J. Chem. Pharm. Res., 2014, 6(6):712-716

40- Bibi Marjan Razavi^a, Hossein Hosseinzadeh^b, Khalil Abnous^c, Alireza Khoei ^d, Mohsen Imenshahidi. Protective effect of crocin against apoptosis induced by subchronic exposure of the rat vascular system to diazinon. Toxicology and Industrial Health

41- Marzieh R1, Hosseinzadeh H, Mohsen I, Parisa L, Bibi Marjan R, Khalil AEffect of exposure to diazinon on adult rat's brain.. Toxicol Ind Health. 2013 Nov 11. [Epub ahead of print

42- B. M. Razavi1, H. Hosseinzadeh2, M. Imenshahidi1, M. Malekian1, M. Ramezani3, K. Abnous. Evaluation of Protein Ubiquitylation in Heart Tissue of Rats Exposed to Diazinon (an Organophosphate Insecticide) and Crocin (an Active Saffron Ingredient):Role of HIF-1α.  Drug Res (Stuttg). 2014 Nov 4. [Epub ahead of print]

43- Imenshahidi, M.a, Razavi, B.M.b, Faal, A.c, Gholampoor, A.c, Mousavi, S.M.c, Hosseinzadeh, H.d Effects of chronic crocin treatment on desoxycorticosterone acetate (doca)-salt hypertensive rats. Iranian Journal of Basic Medical Sciences Volume 17, Issue 1, January 2014, Pages 9-13

44- Imenshahidi, M.a, Alipour, M.a, Hadizadeh, F.b , Motamed-Shariaty, V.S  Hypotensive effect of a novel dihydropyridine with dual calcium channel blocking and angiotensin II antagonistic properties in a rat model. Pharmaceutical Sciences Volume 19, Issue 4, March 2014, Pages 135-138

45- Bibi Marjan Razavi ¹, Ebrahim Arasteh ¹, Mohsen Imenshahidi ¹, Mehrdad Iranshahi ²*Antihypertensive effect of auraptene, a monoterpene coumarin from the genus Citrus, upon chronic administration. Iranian Journal of Basic Medical Science 

46- Mahmoud Hashemzaei1,2, Mohsen Imen Shahidi2, Seyyed Adel Moallem2, Khalil Abnous3, Maryam Ghorbani4 and Amir Hooshang Mohamadpour5. Modulation of JAK2, STAT3 and Akt1 proteins by granulocyte colony stimulating factor following carbon monoxide poisoning in male rat Drug Chem Toxicol, Early Online: 1–5  2016

47- Mitra Asgharian Rezaee a,b, Amir Hooshang Mohammadpour a,c, Mohsen Imenshahidi a, Mahmoud Mahmoudi d, Mojtaba Sankian e, Konstantinos Tsarouhas f, Andreas Tsakalof g, Aristidis Micheal Tsatsakis g, Seyed Adel Moallem. Protective effect of erythropoietin on myocardial apoptosis in rats exposed to carbon monoxide. Life Sciences 148 (2016) 118–124