فعالیتهای تحقیقاتی دکتر سیده هدی علوی زاده

امتیاز کاربران

ستاره غیر فعالستاره غیر فعالستاره غیر فعالستاره غیر فعالستاره غیر فعال
 

Curriculum Vitae

Seyedeh Hoda Alavizadeh (Pharm. D, Ph.D.)

Assistant professor at School of Pharmacy

Mashhad University of Medical Sciences (MUMS), Mashhad, Iran

University Complex, 91775-1365, Mashhad, Iran

 

P.O Box                    91775-1365

Phone                      +98 513-1801334

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Date of birth                        August 14, 1986

 

Languages:

Persian

Fluent English (MCHE grade (82/100), IBT TOEFL (105/120)

French (DELF B1)

Scientific metrics: h index=10; Total citations: 508

ResearchGate            https://www.researchgate.net/profile/Seyedeh_Hoda_Alavizadeh2/publications

Linkedin        

https://www.linkedin.com/in/hoda-alavizadeh-15321a47/

Google Scholar

 (My Citation) https://scholar.google.com/citations?user=98nZnjIAAAAJ&hl=en

 

Background

 

Doctor of Pharmacy and Ph. D. in Pharmaceutical Nanotechnology with experience in innovative drug research and development and academia. Assistant professor with passion for research and teaching in translational drug development, Hands-on experience in lipid-based nanoparticulate formulation development of chemotherapeutics and phytochemicals for parenteral use, Experience on lipid-based antigen delivery systems as vaccine against infection.

Work on developing novel tumor-microenvironment-responsive nanomaterials for anti-cancer drug delivery and theranostics application. The nano platform could sense the tumor micro-environment, enhance drug release and give real-time report on tumor state.

Specialized experience:

 

Background in cancer biology, immunology and nanomedicine

Formulation of poorly water-soluble drugs, technology development for entrapping low-water soluble drugs and phytochemicals in liposome

Presentation skills and scientific writing capabilities

Team work and communication skills

Liposome formulation & characterization, remote-loading, liposome targeting, temperature-sensitive & thermotherapy, stimuli-responsive liposome, Green synthesis, antigens, vaccine, Cell culture, cytotoxicity assay and cellular uptake, In vivo study, survival study, Animal biodistribution, SDS-PAGE, Atomic absorption spectroscopy, ICP-MS, TLC, Spectrophotometry, ELISA (e.g. cytokine and immunoglobulin quantitation)

Computer skills (Microsoft office including Word, PowerPoint and Excel) (ICDL 2 license in computer), Calcucyn, Graphpad instat, Graphpad Prism, Endnote, Macromedia FreeHand MX

 

Education:      

Ph. D in Pharmaceutical Nanotechnology: School of Pharmacy, Mashhad Medical University, Mashhad, Iran 2010-2016

Thesis title: Formulation and characterization of temperature-sensitive nanoliposomal cisplatin targeted with anti-Her-2/neu affibody and evaluation of their antitumor effects with local hyperthermia in vitro and in vivo in mice model bearing tumor (Score: 19.91/20)

Ph.D. supervisors: Mahmoud Reza Jaafari, Pharm. D., Ph.D.; Ali Badiee, Pharm. D., Ph.D.; Shiva Golmohammadzadeh, Pharm. D., Ph.D.

 

Pharm. D.: School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran 2004-2010

Pharm. D. thesis title: Evaluation of lesion development and type of immune response generated in mice inoculated with L. major mixed with LPD nanoparticles containing CpG ODN (Written and available in English) (Score: 19.75/20)

Pharm. D. supervisors: Mahmoud Reza Jaafari, Pharm. D., Ph.D., Ali Khamesipour, M.Sc., Ph.D., Ali Badiee, Pharm. D., Ph.D.

 

Diploma in Experimental Sciences: Mashhad, Iran 2003

Research interests:

 

Liposome, iron & gold nanoparticles

Remote-loading

Targeted drug delivery for cancer therapy

Targeting tumor microenvironment

Stimuli-responsive delivery systems

Biological barriers in drug delivery to tumor and BBB

Vaccine delivery systems against leishmaniasis

Cancer Chemo-immunotherapy

Exosome

Professional Experience:

 

            2016-present

            Assistant professor, Pharmaceutical Nanotechnology Dep, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

            2016-present

            Pharmacy practice, Ghaem Hospital Pharmacy

Activity:

 

2020-Present

            Deputy of graduate studies in School of Pharmacy

            2018-present

            Representative of Pharmaceutical Nanotechnology Department in Pharmacy School Research Council

2019-2020

            Supervisor of Advisory Professors in School of Pharmacy

2018-present

            Journal club supervisor of Pharmaceutical Nanotechnology Department

2016  

Scientific committee member of Mashhad University of Medical Sciences Ph.D.  student conference

2011-2012   

EDO member committee of Mashhad University of Medical Sciences

2011   

Executive committee member in nanotechnology conference, Mashhad, Iran

2010  

Executive and scientific committee member in the 5th Iranian Controlled Release Conference, Mashhad, Iran

Course teaching:

Basic Biochemistry, Basic Biology, Immunology, Biological barriers in drug delivery to cancer microenvironment, Stimuli-responsive drug delivery systems, Cell culture for Pharmaceutical Nanotechnology Ph.D. students, Pharmacy practice for Pharm. D students.

Reviewer in journals:

International Journal of Pharmaceutical Sciences

Molecular Pharmaceutics

Iranian Journal of Basic Medical Sciences    

 

Membership:

ProGRANT Alumnai             

Iranian Nanosociety (INS), Tehran, Iran                   

Nanotechnology Research Center, Pharmaceutical technology institute, Mashhad, Iran

Thesis supervisors & co-supervisors:

 

1. Formulation and characterization of temperature-sensitive nanoliposomal doxorubicin targeted with CGKRK and iRGD peptide and evaluation of their antitumor effects in mice bearing C26 tumor (Ph. D)

2. Preparation and characterization of pH-sensitive polymeric micelles doxorubicin and docetaxel and anti-tumor effect (Ph. D)

3. Preparation of Paclitaxel Nanoliposomal Formulations and Evaluation of Their Anti-Tumor Effects in Tumor-Bearing Balb/C Mice (Ph. D)

4. Formulation and evaluation of Glatiramer acetate nanoliposomes for treatment of multiple sclerosis (MS) (Ph. D)

5. Preparation and characterization of cationic liposomal doxorubicin targeted via MMP2 peptide and evaluation of their anti-tumor effects in vitro and in vivo (Ph. D)

6. Oxidation-sensitive liposomes containing doxorubicin and evaluation of their anti-tumor activity (Ph. D)

7. Preparation of nanoliposomal Epacadostat and evaluation of its antitumor effects on melanoma cancer cells(B16F10) in vivo and in vitro alone or in combination with Free docetaxel (Ph. D)

8. Preparation of Glutathione PEGylated nano Liposomal Doxorubicin for treatment of brain cancer (Ph. D)

9. Remote loading of cisplatin into preformed liposomes using Glutamic acid (Pharm. D)

10. Remote loading of cisplatin into preformed liposomes using Aspartic acid (Pharm. D)

11. Remote loading of cisplatin into preformed liposomes using Calcium acetate (Pharm. D)

12. Efficacy of Silimarin nanoliposome on cadmium induced toxicity in human lung carcinoma A549 cell (Pharm. D)

Other projects:

 

1. Evaluation of protective effects of silybin against acetaminophen-induced hepatotoxicity in mice

2. Development and characterization of tween80 containing nanoliposomal doxorubicin for delivery to brain

3. Anti-Tumor Effects of Doxil And Ellagic Acid Nanoliposomes In Melanoma Tumor-Bearing C57/BL6 Mice

International publications:

 

1. Jaafari MR*, Hatamipour M, Alavizadeh SH, Abbasi A, Saberi Z, Rafati S, et al. (2019): Development of a topical liposomal formulation of Amphotericin B for the treatment of cutaneous leishmaniasis. International Journal for Parasitology: Drugs and Drug Resistance.

 

2. Kavian Z, Alavizadeh SH, Golmohamadzadeh SH, Badiee A, Khamesipour A, Jaafari MR* (2019): Development of topical liposomes containing miltefosine for the treatment of Leishmania major infection in susceptible BALB/c mice. Acta tropica. 142-149 pp.

 

3. Zendehdel, E., Abdollahi, E., Momtazi‐Borojeni, AA., Korani, M, Alavizadeh, SH., Sahebkar, AH. * (2018): The molecular mechanisms of curcumin’s inhibitory effects on cancer stem cells. Journal of cellular biochemistry. 1-9 pp.

 

4. Hatamipour, H., Sahebkar AH., Alavizadeh, SH., Dorri, M., Jaafari, MR.* (2019): Novel nanomicelle formulation to enhance bioavailability and stability of curcuminoids. Iranian journal of basic medical sciences. 282-289 pp.

 

5. Gheybi F, Alavizadeh SH, Rezayat SM, Zendedel E, Jaafari MR.* (2019): Chemotherapeutic activity of Silymarin combined with doxorubicin liposomes in 4T1 breast cancer cells. Nanomedicine Research Journal. 29-34 pp.

 

6. Balarastaghi, S., Khashaiarmanesh, Z., Makhdoumi, P., Alavizadeh, SH., Sameie Moghadam Z., Shirani K, Karimi, GH. * (2018): Determination of toxic element levels (lead and cadmium) in commonly used cosmetic products in Iran. Toxin Reviews. 117-122 pp.

 

7. Firouzmand, H., Sahranavard, M., Badiee, A., Khamesipour, A., Alavizadeh, SH., Samiei, A., Soroush, D., Tavassoti. KM., Mahboudi, F., Jaafari, MR.* (2017): The role of LPD-nanoparticles containing recombinant major surface glycoprotein of Leishmania (rgp63) in protection against leishmaniasis in murine model. Immunopharmacology and immunotoxicology. 72-82 pp.

 

8. Iman, M., Huang, Z., Alavizadeh, SH, Szoka, Jr FC., Jaafari, MR.* (2017): Biodistribution and In Vivo Antileishmanial Activity of 1, 2-Distigmasterylhemisuccinoyl-sn-Glycero-3-Phosphocholine Liposome-Intercalated Amphotericin B. Antimicrobial agents and chemotherapy. e02525-16 pp.

 

9. Hojatizade, M., Badiee, A., Khamesipour, A., Mirshafiey, A., Akhtari., J, Mehravaran, A., Alavizadeh SH., Abbasi, A., Saberi, Z., Nikpoor, AR., Jaafari., MR.* (2017): DDA/TDB liposomes containing soluble Leishmania major antigens induced a mixed Th1/Th2 immune response in BALB/c mice. Nanomedicine Journal. 71-82 pp.

 

10. Alavizadeh, SH., Gheybi, F., Nikpoor, AR., Badiee, A., Golmohammadzadeh, S., Jaafari, MR.* (2017): Therapeutic Efficacy of Cisplatin Thermosensitive Liposomes upon Mild Hyperthermia in C26 Tumor Bearing BALB/c Mice. Molecular Pharmaceutics. 712-721pp.

 

11. Abbaszadegan, S., Hosseinzadeh, H., Alavizadeh, SH., Mohamadi, M., Abbasi, A., Jaafari. * (2016): Characterization and anti-tumor activity of PEGylated nanoliposomes containing safranal in mice bearing c26 colon carcinoma. International Journal of Pharmaceutical Sciences and Research. 4379-4386 pp.

 

12. Fakhraee, F., Badiee, A., Alavizadeh, SH., Jalali, SA., Chavoshian, O., Khamesipour, A., Mahboudid, F., Jaafari, MR.* (2016): Coadminstration of L. major amastigote class I nuclease (rLmaCIN) with LPD nanoparticles delays the progression of skin lesion and the L. major dissemination to the spleen in BALB/c mice- based experimental setting. Acta Tropica. 211-18 pp.

 

13. Alavizadeh, SH., Soltani, F., Ramezani, M. * (2016): Recent Advances in Immunoliposome-Based Cancer Therapy. Current Pharmacology. 129-41 pp.

 

14. Akhtari, J., Rezayat, SM., Teymouri, M., Alavizadeh, SH., Badiee, A., Gheybi, F., Hojatizadeh, M., Jalali, A., Jaafari, MR.* (2016): Targeting, bio distributive and therapeutic characterization of anti-HER2 affibody coupling to liposomal doxorubicin using BALB/c mice bearing TUBO tumors. International Journal of Pharmaceutics. 89-95 pp.

 

15. Alavizadeh, SH., Akhtari, J., Badiee, A., Golmohammadzadeh, Sh., Jaafari, MR.* (2016): HER2 affibody-targeted cisplatin liposome inhibits the growth of HER2-expressing breast tumor models. Expert Opinion on Drug Delivery. 325-36 pp.

 

16. Marzban, E., Alavizadeh, SH., * Ghiadi, M., Khoshangosht, M., Khashayarmanesh, Z., Abbasi, A., Jaafari, MR., * (2015): Optimizing the therapeutic efficacy of cisplatin PEGylated liposomes via incorporation of different DPPG ratios: in vitro and in vivo studies. Colloids and Surfaces B: Biointerfaces. 885-91 pp.

 

17. Alavizadeh, SH., Badiee, A., Golmohammadzadeh, Sh., Jaafari, MR.* (2014): The influence of phospholipid on the physicochemical properties and antitumor efficacy of liposome encapsulating cisplatin in mice bearing C26 colon carcinoma. International Journal of Pharmaceutics. 326-33 pp.

 

18. Alavizadeh, SH., Hosseinzadeh, H.* (2014): Bioactivity assessment and toxicity of crocin: a comprehensive review. Food and Chemical Toxicology. 65-80 pp.

 

19. Firouzmand, H., Badiee, A., Khamesipour, A., Heravi Shargh, V., Alavizadeh, SH., Abbasi, A., Jaafari, MR.* (2013): Induction of protection against leishmaniasis in susceptible BALB/c mice using simple DOTAP cationic nanoliposomes containing soluble Leishmania antigen (SLA). Acta Tropica. 528-35 pp.

 

20. Rastgoo, M., Hosseinzadeh, H., * Alavizadeh, SH., Abbasi, A., Ayati, Z., Jaafari, MR.* (2013): Antitumor activity of PEGylated nanoliposomes containing crocin in mice bearing C26 colon carcinoma. Planta Medica. 447-51 pp.

 

21. Alavizadeh, SH., Badiee, A., Khamesipour, A., Jalali, SA., Firouzmand, H., Abbasi, A., Jaafari, MR.* (2012): The role of liposome-protamine-DNA nanoparticles containing CpG oligodeoxynucleotides in the course of infection induced by Leishmania major in BALB/c mice. Experimental Parasitology. 313-9 pp.

*Corresponding author

The following above mentioned publications have evolved from my doctoral dissertation:

 

10-15-16-17 (Ph.D.)

21 (Pharm. D)

 

Conference Presentations:

 

1. Seyedeh Hoda Alavizadeh, Fatemeh Gheybi, Kebria Houshangi, Mahmoud Reza Jaafari, Hepatoprotective Effect of Silybin Liposome Against Acetaminophen Toxicity: in Vivo Study. IPSC2019, November 8-10, Kermanshah, Iran (Poster presentation)

 

2. Seyedeh Hoda Alavizadeh, Fatemeh Gheybi, Amin Reza Nikpoor, Mahmoud Reza Jaafari, optimizing stealth cisplatin liposomes by using mild hyperthermia and triggered content release in vivo. ILS/LRD Liposome Advances Conference, September 16-18 2017, Athens, Greece (Platform presentation)

3. Seyedeh Hoda Alavizadeh, Mahmoud Reza Jaafari, Optimizing cisplatin thermosensitive liposomes to improve therapeutic efficacy at mild hyperthermia in C26 tumor bearing BALB/c mice. The European Summit for Clinical Nanomedicine and Targeted Medicine, the Translation to Knowledge Based Nanomedicinem, 10th Conference and Exhibition, May 7-10, 2017, Basel, Switzerland (Poster presentation and small speech).

 

4. Seyedeh Hoda Alavizadeh, Mahmoud Reza Jaafari, Anti-cancer activity of anti-HER2 affisome containing cisplatin in animals with breast cancer. 1ST International Nastaran Cancer Symposium,October 1st 2015, Mashhad, Iran (Poster presentation).

 

5. Seyedeh Hoda Alavizadeh, Mahmoud Reza Jaafari, Targeted delivery of anti-HER2 affibody conjugated sterically stabilized cisplatin liposome in HER2 receptor-expressing breast cancer models. The European Summit for Clinical Nanomedicine and Targeted Medicine, the Translation to Knowledge Based Nanomedicinem, 8th Conference and Exhibition, June 28-July 1, 2015, Basel, Switzerland (Poster presentation and small speech).

 

6. Seyedeh Hoda Alavizadeh, Ali Badiee, Shiva Golmohammadzadeh, Mahmoud Reza Jaafari, The influence of bilayer composition on the physicochemical properties and anti-tumor efficacy of liposome encapsulating cisplatin in mice bearing C26 colon carcinoma, The First Middle East & The 6th Iranian Control Release Conference, February 25-27, 2014, Tehran, Iran (Platform presentation).

 

7. Seyedeh Hoda Alavizadeh, Badiee, A, Khamesipour, A, Jalali, A, Tavassoti Kheiri, M, Barkhordari, F, Mahboudi, F, Jaafari, MR. Preparation and characterization of LPD nanoparticles containing rgp63 and rLmaCIN as a vaccine against cutaneous leishmaniasis, 13th Iranian Pharmaceutical Sciences Congress, 3-6 september 2012, Isfehan, Iran, Research in Pharmaceutical Sciences, 2012;7(5); (Poster presentation) (Awarded Best Poster Presentation).

 

8. Seyedeh Hoda Alavizadeh, Mahmoud Reza. Jaafari, Ali Badiee, Ali Khamesipour, Amir Jalali, Azam Abbasi, Evaluation of lesion development and type of immune response generated in mice inoculated with L. major mixed with LPD nanoparticles containing CpG ODN, 3rd Conference on Nanostructures, March 10-12, 2010, Sharif University of Technology, International Campus, Kish Island, Iran. ( Platform presentation).

 

 

9. Seyedeh Hoda Alavizadeh, Ali Badiee, Mahmoud Reza Jaafari, Lipid-Protamine-DNA (LPD) nanoparticles as a vaccine delivery system for cancer immunotherapy, The Specialized Congress and International Exhibition of Nanomedicine, Nanobiotechnology, Nanobiosensors and Nanomaterials, July 14-16, 2009, Mashhad, Iran, Iran J Basic Med Sci, Vol. 12, No. 2, (Poster Presentation).

 

Honors and awards:

 

NIMAD grant, 2018

Fellowship of CLINAM foundation for The European Summit for Clinical Nanomedicine 2017 (10th CLINAM) Basel- Switzerland.

Poster presentation award in the European Summit for Clinical Nanomedicine and Targeted Medicine, the Translation to Knowledge Based Nanomedicinem, 10th Conference and Exhibition, May 7-10, 2017, Basel, Switzerland.

1% top papers of the World as reported by Essential Science Indicator of Thompson Reuter ISI in 2016 [Alavizadeh SH, Hosseinzadeh H. Bioactivity assessment and toxicity of crocin: a comprehensive review. Food Chem Toxicol. 2014; 64:65-80].

The second best Ph. D student award in the field of research in Research Festival of School of Pharmacy, Mashhad, 2014

The top research paper in Research Festival of School of Pharmacy, Mashhad, 2014

The second best Ph. D student award in the field of research in Research Festival of School of Pharmacy, Mashhad, 2013

The top research paper in Research Festival of School of Pharmacy, Mashhad, 2013

The best poster presentation award in 13 th Iranian Pharmaceutical Scienses Congress, Isfahan, Iran, 2012

 

Other educational documents:

 

2016 Scientific committee member of Mashhad University of Medical Sciences PhD student conference

2013 Attendance certificate in Transmission Electron Microscopy from Tehran Nanotechnology Festival

2013 Attendance certificate in Electronic Record Preservation from Pharmacy School of Mashhad

2011 Attendance certificate in Flow Cytometry from Avicenna Research Institute

2011 Attendance certificate in Nanobiotechnology by professor G. Ali mansoori from nanotechnology society of Azad University of Mashhad

2011 Attendance certificate in Artificial Receptor Prepared by Molecular Imprinting form Avicenna Research Institute

2011 Attendance certificate in SOPS (Standard Operating Procedure) from Pharmacy School of Mashhad

2011 Attendance certificate in Outlook from Pharmacy School of Mashhad

2010 Attendance certificate in PCR (Polymerase Chain Reaction) form Avicenna Research Institute

2010 Attendance certificate in Business Plan, Writing in Nanoscience from Mashhad Nanotechnology Conference

2009    Attendance certificate in Herbal Medicine from Pharmacy School of Mashhad