دانشکده داروسازی

فعالیتهای تحقیقاتی دکتر سیده هدی علوی زاده - انگلیسی

امتیاز کاربران

ستاره غیر فعالستاره غیر فعالستاره غیر فعالستاره غیر فعالستاره غیر فعال
 
 
 

Curriculum Vitae

 

Seyedeh Hoda Alavizadeh (Pharm.D., Ph.D.)

Ph.D. of Pharmaceutical Nanotechnology


Assistant professor

Department of Pharmaceutical Nanotechnology, School of Pharmacy,

Mashhad University of Medical Sciences, Mashhad, Iran

P.O Box: 91775-1365

Phone              +98 51-

Fax                  +98 513-8823251

 

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Education                  

 

  • 2011-2016: Ph.D. student of Pharmaceutical Nanotechnology in School of Pharmacy, Mashhad Medical University, Mashhad, Iran
  • Thesis title: Formulation and characterization of temperature-sensitive nanoliposomal cisplatin targeted with anti-Her-2/neu affibody and evaluation of their antitumor effects with local hyperthermia in vitro and in vivo in mice model bearing tumor.
  • Ph.D. supervisors: Mahmoud Reza Jaafari, Pharm. D., Ph.D.; Ali Badiee, Pharm. D., Ph.D.; Shiva Golmohammadzadeh, Pharm. D., Ph.D.
  • 2004-2010: Pharm. D, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  • Pharm. D. thesis title: Evaluation of lesion development and type of immune response generated in mice inoculated with L. major mixed with LPD nanoparticles containing CpG ODN (Written and available in English)
  • Pharm. D. supervisors: Mahmoud Reza Jaafari, Pharm. D., Ph.D., Ali Khamesipour, M.Sc., Ph.D., Ali Badiee, Pharm. D., Ph.D.

 

International publications

 1- AbbaszadeganS, Hosseinzadeh H, Alavizadeh SH, Mohammadi M, AbbasiA, Jaafar MR., Characterization and anti-tumor activity of PEGylated nanoliposomes containing safranal in mice bearing C26 colon carcinoma. International Journal of Pharmaceutical Sciences and Research (ahead of print).

 2-Fakhraee F, Badiee A, Alavizadeh SH, Jalali SA, Chavoshian O, Khamesipour A, Mahboudid F, Jaafari MR. Coadminstration of L. major amastigote class I nuclease (rLmaCIN) with LPD nanoparticles delays the progression of skin lesion and the L .major dissemination to the spleen in BALB/c mice- based experimental setting. Acta Tropica 2016 July, 159: 211-218.

 3-Alavizadeh SH, Soltani F, Ramezani M., Recent Advances in Immunoliposome-Based Cancer Therapy. Current Pharmacology Report, 2016 May; 2 (3): 129-141.

 4-Akhtari J, Rezayat SM,  Teymouri M, Alavizadeh SH, Badiee A , Gheybi F, Hojatizadeh M, Jalali A, Jaafari MR. Targeting, bio distributive and therapeutic characterization of anti-HER2 affibody coupling to liposomal doxorubicin using BALB/c mice bearing TUBO tumors. International Journal of Pharmaceutics, 2016 May; 505 (1-2): 89-95.

 5- Alavizadeh SH, Akhtari J, Badiee A, Golmohammadzadeh Sh, Jaafari MR., Improved therapeutic activity of HER2 Affibody-targeted cisplatin liposomes in HER2-expressing breast tumor models. Expert Opinion on Drug Delivery, 2016 Mar; 13(3):325-36.

 6- Marzban E, Alavizadeh SH, Ghiadi M, Khoshangosht M, Khashayarmanesh Z, Abbasi A, Jaafari MR., Optimizing the therapeutic efficacy of cisplatin PEGylated liposomes via incorporation of different DPPG ratios: in vitro and in vivo studies. Colloids and Surfaces B: Biointerfaces, 2015 Nov, 136; 885-891.

 7- Alavizadeh SH, Badiee A, Golmohammadzadeh Sh, Jaafari MR., The influence of phospholipid on the physicochemical properties and antitumor efficacy of liposome encapsulating cisplatin in mice bearing C26 colon carcinoma. International Journal of Pharmaceutics. 2014 Oct, 473; 326-333.

 8-Alavizadeh SH, Hosseinzadeh H., Bioactivity assessment and toxicity of crocin: a comprehensive review. Food and Chemical Toxicology. 2014 Feb; 64: 65-80.

 9- Firouzmand H, Badiee A, Khamesipour A, Heravi Shargh V, Alavizadeh SH, Abbasi A, Jaafari MR., Induction of protection against leishmaniasis in susceptible BALB/c mice using simple DOTAP cationic nanoliposomes containing soluble Leishmania antigen (SLA). Acta Tropica. 2013 Dec; 128(3):528-35.

 10- Rastgoo M, Hosseinzadeh H, Alavizadeh SH, Abbasi A, Ayati Z, Jaafari MR., Antitumor activity of PEGylated nanoliposomes containing crocin in mice bearing C26 colon carcinoma. Planta Medica. 2013 Apr; 79(6):447-51.

 11- Alavizadeh SH, Badiee A, Khamesipour A, Jalali SA, Firouzmand H, Abbasi A, Jaafari MR., The role of liposome-protamine-DNA nanoparticles containing CpG oligodeoxynucleotides in the course of infection induced by Leishmania major in BALB/c mice. Experimental Parasitology. 2012 Nov; 132(3):313-9.

 

Presentations

1. Seyedeh Hoda Alavizadeh, Ali Badiee, Mahmoud Reza Jaafari, Lipid-Protamine-DNA (LPD) nanoparticles as a vaccine delivery system for cancer immunotherapy, The Specialized Congress and International Exhibition of Nanomedicine, Nanobiotechnology, Nanobiosensors and Nanomaterials, July 14-16, 2009, Mashhad, Iran, Iran J Basic Med Sci, Vol. 12, No. 2, (Poster Presentation).

2. Seyedeh Hoda Alavizadeh, Mahmoud Reza. Jaafari, Ali Badiee, Ali Khamesipour, Amir Jalali, Azam Abbasi, Evaluation of lesion development and type of immune response generated in mice inoculated with L. major mixed with LPD nanoparticles containing CpG ODN, 3rd Conference on Nanostructures, March 10-12, 2010, Sharif University of Technology, International Campus, Kish Island, Iran. (English Oral Presentation).
     
3. Seyedeh Hoda Alavizadeh, Badiee, A, Khamesipour, A, Jalali, A, Tavassoti Kheiri, M, Barkhordari, F, Mahboudi, F, Jaafari, MR. Preparation and characterization of LPD nanoparticles containing rgp63 and rLmaCIN as a vaccine against cutaneous leishmaniasis, 13th Iranian Pharmaceutical Sciences Congress, 3-6 september 2012, Isfehan, Iran, Research in Pharmaceutical Sciences, 2012;7(5); (Poster presentation) (Awarded Best Poster Presentation).
   
4. Seyedeh Hoda Alavizadeh, Ali Badiee, Shiva Golmohammadzadeh, Mahmoud Reza Jaafari, The influence of bilayer composition on the physicochemical properties and anti-tumor efficacy of liposome encapsulating cisplatin in mice bearing C26 colon carcinoma, The First Middle East & The 6th Iranian Control Release Conference, February 25-27, 2014, Tehran, Iran (English Oral Presentation).
   
5. Seyedeh Hoda Alavizadeh, Mahmoud Reza Jaafari, Targeted delivery of anti-HER2 affibody conjugated sterically stabilized cisplatin liposome in HER2 receptor-expressing breast cancer models. The European Summit for Clinical Nanomedicine and Targeted Medicine, the Translation to Knowledge Based Nanomedicinem, 8th Conference and Exhibition, June 28-July 1, 2015, Basel, Switzerland (Poster presentation).


6. Seyedeh Hoda Alavizadeh, Mahmoud Reza Jaafari, Anti-cancer activity of anti-HER2 affisome containing cisplatin in animals with breast cancer. 1ST International Nastaran Cancer Symposium, October 1st 2015, Mashhad, Iran (Poster presentation).
 
7. Seyedeh Hoda Alavizadeh, Mahmoud Reza Jaafari, Formulation and optimization of cisplatin thermosensitive liposomes to improve therapeutic efficacy at mild hyperthermia in C26 tumor bearing BALB/c mice. International Nanomedicine Conference, Sydney Australia 6-8 July 2016 "accepted for oral presentation".

 

Honors and awards

 1- The paper [Alavizadeh SH, Hosseinzadeh H. Bioactivity assessment and toxicity of crocin: a comprehensive review. Food Chem Toxicol. 2014; 64:65-80] ranked among the top 1% papers of the World as reported by Essential Science Indicator of Thompson Reuter ISI in 2016.

 2- The paper [Alavizadeh SH, Hosseinzadeh H. Bioactivity assessment and toxicity of crocin: a comprehensive review. Food Chem Toxicol. 2014; 64:65-80] ranked as a hot paper as defined by Thomson Reuters database processing dates in 2016.

 3- The second best Ph. D student award in the field of research in Research Festival of School of Pharmacy, Mashhad, 2014

 4- The top research paper in Research Festival of School of Pharmacy, Mashhad, 2014

 5- The second best Ph. D student award in the field of research in Research Festival of School of Pharmacy, Mashhad, 2013

 6- The top research paper in Research Festival of School of Pharmacy, Mashhad, 2013

 7- The best poster presentation award in 13 th Iranian Pharmaceutical Scienses Congress, Isfahan, Iran, 2012 

 

Research interests

Liposomal drug delivery

Targeted drug delivery

Cancer therapy

Triggered release drug delivery systems

Lipid-based delivery and adjuvant systems for leishmaniasis.

 

Languages

  • Persian
  • Fluent English (MCHE grade (82/100), IBT TOEFL (105/120)
  • French (DELF B1)