فعالیتهای تحقیقاتی دکتر محسن ایمن شهیدی

امتیاز کاربران

ستاره غیر فعالستاره غیر فعالستاره غیر فعالستاره غیر فعالستاره غیر فعال
 

 

Curriculum Vitae

 

Mohsen Imenshahidi (Pharm.D., Ph.D.)

Professor in Pharmacology,

School of Pharmacy,

Mashhad University of Medical Sciences,

Mashhad-Iran

P.O.Box: 91775-1365

Phone: +98-51-31801192 (Office)

Fax: +98-511-8823251

E-mail: این آدرس ایمیل توسط spambots حفاظت می شود. برای دیدن شما نیاز به جاوا اسکریپت دارید

 

Pharm. D.: School of Pharmacy, Mashhad University of Medical Sciences (1993-1998).

Ph.D. (Pharmacology): School of Medicine, Mashhad University of Medical Sciences (1998-2004).

Research fellowship: Heart Institute, University of Ottawa, Canada.

Ph. D. thesis title: Evaluation of Lovastatin effect on endothelium-dependent and –independent vascular relaxation in diabetic rats.

 

Research Interest

- Cardiovascular pharmacology using isolated aortic rings and mesenteric bed

- CNS and behavioral pharmacology

 

Publishes

1- Imen shahidi, M., Fatehi, Z., Parsaie, H. 2004. Effect of lovastatin on acetylcholine induced relaxation in the isolated mesenteric bed of streptozotocin diabetic rats. Iranian Journal of Basic Medical Sciences; 7(2): 58-64.

2- Fatehi-Hassanabad, Z., Fatehi, M., Iman Shahidi, M. 2004. Endothelial dysfunction in aortic rings and mesenteric beds isolated from desoxycorticosterone acetate hypertensive rats: Possible involvement of protein kinase C. Eur J Pharmacol; 494: 199-204.

3-Fatehi, M., Fatehi-Hassanabad, Z., Imen shahidi, M., Razavi-Tossi, M. 2004. Effects of protein kinase C inhibitor on the responses to the vasodilator agents in the isolated aorta and mesenteric bed from hypertensive rats. Iranian Journal of Basic Medical Sciences; 6(4): 307-314.

4-Khooei, A.R., Hosseinzadeh, H., Iman Shahidi, M. 2002. Pathologic Evaluation of anti-ischemic effect of Salvia Lerrifolia Benth. Seed and leaf extracts in rats after global cerebral ischemia. Iranian Journal of Basic Medical Sciences; 4(2): 234-239.

5-Iman Shahidi, M., Hosseinzadeh, H. 2002. Animal models of diabetes. Iranian Journal of Diabetes and Lipid; 2(1): 1-10.

6-Hosseinzadeh, H., Iman Shahidi, M. 1999. Effect of Salvia Lerrifolia Benth. Seed and leaf extracts on Survival time in hypoxic mice. Iranian Journal of Basic Medical Sciences; 2(2): 75-81.

7-Fatehi-Hassanabad Z, Imen-Shahidi M, Fatehi M, Farrokhfall K, Parsaeei H. 2006. The beneficial in vitro effects of lovastatin and chelerythrine on relaxatory response to acetylcholine in the perfused mesentric bed isolated from diabetic rats. Eur J Pharmacol. 535(1-3): 228-33.

8-Mohsen Imanshahidi and Hossein Hosseinzadeh. 2006. The Pharmacological Effects of Salvia species on the Central Nervous System. Res. 20(6): 427-37.

9-Mohsen Imanshahid. Effect of ExtracellularCalcium Depletion on Atrial Natriuretic FactorSecretion and Gene Expression. Iranian Journal of Pharmaceutical Sciences. Winter 2006: 2(1): 23-30.

10-Heydar Parsaee, Mohsen Imenshahidi, Zahra Fatehi. 2006. Lovastatin incubation improves acetylcholine-induced relaxation in isolated aortic rings of diabetic rat. IJPR. 3: 191-198.

11- Mohsen Imenshahidi, Hossein Hosseinzadeh, Ali Es'haghian. 2007. EFFETS OF ETHOSUXIMIDE ON MORPHINE TOLERANCE AND DEPENDENCE IN MICE. Pharmacologyonline 2: 287-299.

12- Mohsen Imanshahidi, Hossein Hosseinzadeh. Pharmacological and Therapeutic Effects of Berberis vulgaris and its Active Constituent, Berberine. Phytother. Res. 22, 999–1012 (2008).

13- Farzin Hadizadeh, Mohsen Imenshahidi, Fatemeh Mohammadpour, Pooya Mihanparast  and Mahmoud Seifi. SYNTHESIS AND CALCIUM CHANNEL ANTAGONIST ACTIVITY OF 4-[(HALOBENZYL)IMIDAZOLYL]  DIHYDROPYRIDINES. Saudi Pharmaceutical Journal, Vol. 17, No. 2 April 2009, 170-176.

14- Hossein Hosseinzadeh,  Hamid Reza Sadeghnia,  Mohsen Imenshahidi,  Bibi Sedigheh Fazly Bazzaz. Review of the Pharmacological and Toxicological Effects of Salvia leriifolia. Iranian Journal of Basic Medical Sciences Vol. 12, No. 1, Spring 2009, 1-8.

15- Karimi G, ImenshahidiM, Jafarizaveh E, Asgharian Rezaee M. VASODILATOR EFFECT OF OLIVE LEAF AQUEOUS EXTRACT AND IVOLVMET OF CYCLOOXYGEASE I THE RAT AORTA. Pharmacologyonline 2: 365-371 (2009)

16- Farzin Hadizadeh, Mohsen Imenshahidi, Payman Esmaili, Morteza Taghiabadi. Synthesis and Effects of Novel Dihydropyridines as Dual Calcium Channel Blocker and Angiotensin Antagonist on Isolated Rat Aorta. Iranian Journal of Basic Medical Sciences.  13, 2010, 195-201.

17- Imenshahidi M, Hosseinzadeh H, Javadpour Y. Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats. Phytother Res 2010 Jul;24(7):990-4

18- Imenshahidi M, Karimi GH, Kazemzadeh E. Effects of Atorvastatin on Nitrate Tolerance in Diabetic Rats. IJPR. 2010; 9(1), 55-59.

19- Mohsen Imenshahidia, Farzin Hadizadeha,b*, Asieh Firoozeh-Moghadama, Mahmoud Seifia, Atefeh Shirinbaka and Mohammad Bagher Gharedaghia. Synthesis and vasorelaxtion properties of 9-aryl- 1,8-acridinediones as potassium channel openers in isolated rat aorta. Iranian Journal of Pharmaceutical Research (2012), 11 (1): 229-233

20- Mohammad Reza Saberi, *2Farzin Hadizadeh, 1Mohsen Imenshahidi, 2Hadi Shakeri, 2Seyedeh Toktam Ziaee, 1Mohammad Ali Ghafuri, 1Ramin Sakhtianchi, 1Zohreh Badieyan, 1Somieh Hajian. Synthesis and Effects of 4,5-Diaryl-2-(2-alkylthio-5-imidazolyl) Imidazoles as Selective Cyclooxygenase Inhibitors. Iranian Journal of Basic Medical Sciences Vol. 13, No. 4, Autumn 2010, 207-212

21- Imenshahidi, M., Zafari, H. and Hosseinzadeh, H. (2011). Effect of crocin on the acquisition and reinstatement of morphine-induced conditioned place preference in mice. Pharmacologyonline 1: 1007-1013.

22- Mohamadpour AH, Moallem SA, Hashemzaei M, Abnous K, Tabatabaee Yazdi SA, Imenshahidi M. Effects of granulocyte colony-stimulating factor on electrocardiogram changes after carbon monoxide poisoning in rats. Drug Chem Toxicol. 2012 Oct;35(4):353-60.

23- Mohsen Imenshahidi1, Ramin Rezaee2, Amin Mostofi2 , Gholamreza Karimi2*

Evaluation of nitric oxide or opioid receptors involvement in antinociceptive properties of silymarin Avicenna Journal of Phytomedicine Received: Sep 26, 2011; Accepted: Nov 6, 2011

 24- Hosseinzadeh H, Imenshahidi M, Hosseini M, Razavi BM. Effect of Linalool on Morphine Tolerance and Dependence in Mice. Phytother Res. 2012 Sep;26(9):1399-404.

25- Hossein Hosseinzadeh , Mohsen Imenshahidi, Alireza Arasteh.  Effects of aqueous saffron extract (Crocus sativus L.) on the acquisition and reinstatement of morphine-induced conditioned place preference in mice. Avicenna Journal of Phytomedicin e

Vol. 2, No. 1, Winter 2012, 24-30

26- . Mohsen Imenshahidi1, Mohammad Eghbal1, Amirhossein Sahebkar2, Mehrdad

Iranshahi2* Hypotensive activity of auraptene, a monoterpene coumarin from Citrus spp. Pharm Biol. 2013 May;51(5):545-9

27- Mitra Asgharian Rezaeea, Seyed Adel Moallema,b,d, Mohsen Imenshahidia,

Mahdi Farzadniac and Amir Hooshang Mohammadpoura, Effects of Erythropoietin on Electrocardiogram Changes in Carbon Monoxide Poisoning: an Experimental Study in Rats. Iranian Journal of Pharmaceutical Research (2012), 11 (4): 1191-1199

28- Elahe Taghiabadi,1 Mohsen Imenshahidi,2 Khalil Abnous,3 Fatemeh  Mosafa,4 Mojtaba Sankian,5 Bahram Memar,6 and Gholamreza Karimi7. Protective Effect of Silymarin against Acrolein-Induced Cardiotoxicity in Mice. Evidence-Based Complementary and Alternative Medicine Volume 2012 (2012), Article ID 352091, 14 pages

29- Marjan Razavi1, Hossein Hosseinzadeh2, Khalil Abnous3, Vahideh Sadat Motamedshariaty4, Mohsen Imenshahidi*. Crocin Restores Hypotensive Effect of Subchronic Administration of Diazinon in Rats. Iranian Journal of Basic Medical Sciences. Volume 16, Number 1, January 2013, Page 64-72.

30- Razavi BM, Hosseinzadeh H, Movassaghi AR, Imenshahidi M, Abnous K. Protective effect of crocin on diazinon induced cardiotoxicity in rats in subchronic exposure. Chem Biol Interact. Chemico-Biological Interactions 203 (2013) 547–555.

31- Maryam Hassanpour Moghadam, Mohsen Imenshahidi, and Seyed Ahmad Mohajeri Antihypertensive Effect of Celery Seed on Rat Blood Pressure in Chronic AdministrationJ Med Food 16 (6) 2013, 558–563

32- Mohsen Imenshahidi, Bibi Marjan Razavi, Ayyoob Faal, Ali Gholampoor, Seyed Mehran Mousavi, Hossein Hosseinzadeh. (2013). The effect of chronic administration of saffron (Crocus sativus) stigma aqueous extract on systolic blood pressure in rats. Jundishapur J Nat Pharmac Prod 8 ( 4 ) pp. 175 - 179

33- Mohsen Imenshahidi, Bibi Marjan Razavi, Ayyoob Faal, Ali Gholampoor, Seyed Mehran Mousavi, Hossein Hosseinzadeh. (2013). The effect of chronic administration of safranal on systolic blood pressure in rats. ranian Journal of Pharmaceutical Research (2015), 14 (2):

34- Seyed Adel Moallem1,3, Mohsen Imenshahidi1, Narges Shahini1,  Ahmad Reza Javan1, Mohsen Karimi1, Mona Alibolandi2, Morteza Ghandadi1,  Leila Etemad1, Vahidehsadat Motamedshariaty4 , Farzin Hadizadeh1,2* Synthesis, anti-inflammatory and anti- nociceptive activities and in vitro antitumor effect of novel thiazolidin 4-ones derivatives as selective cyclooxygenase (COX-2) inhibitors Iran J Basic Med Sci. Dec 2013; 16(12): 1238–1244

35- Mohsen Imenshahidi1, Reza Qaredashi2, Mahmoud Hashemzaei3 and Hossein Hosseinzadeh4   2014  Inhibitory effect of Berberis vulgaris aqueous extract on acquisition and reinstatement effects of morphine in conditioned place preferences (CPP) in mice Jundishapur J Nat Pharm Prod. 2014 Jun 16;9(3):e16145. eCollection 2014 Aug

36- Ghazanfari S, Imenshahidi M, Etemad L, Moshiri M, Hosseinzadeh H. Effect of Cyanocobalamin (vitamin B12) in the Induction and Expression of Morphine Tolerance and Dependence in Mice.Drug Res (Stuttg). 2013 Oct 8. [Epub ahead of print]

37- Lari P, Abnous K, Imenshahidi M, Rashedinia M, Razavi M, Hosseinzadeh H. Evaluation of diazinon-induced hepatotoxicity and protective effects of crocin. Toxicol Ind Health. 2013 Feb 13. [Epub ahead of print]

38- Razavi BM1, Hosseinzadeh H, Abnous K, Imenshahidi M. Protective effect of crocin on diazinon induced vascular toxicity in subchronic exposure in rat aorta ex-vivo. Drug Chem Toxicol. 2014 Jan 7. [Epub ahead of print]

39- Moein Rashidifar1, Mohsen Imenshahidi1, Neda Rahmani-Fazli2 and Farzin Hadizadeh2*.  Synthesis and evaluating cardiac effects of 3,4-dihydropyrimidin-2-one-5-carboxylates in isolated atria of animal model. J. Chem. Pharm. Res., 2014, 6(6):712-716

40- Bibi Marjan Razavia, Hossein Hosseinzadehb, Khalil Abnousc, Alireza Khoei d, Mohsen Imenshahidi. Protective effect of crocin against apoptosis induced by subchronic exposure of the rat vascular system to diazinon. Toxicology and Industrial Health

41- Marzieh R1, Hosseinzadeh H, Mohsen I, Parisa L, Bibi Marjan R, Khalil AEffect of exposure to diazinon on adult rat's brain.. Toxicol Ind Health. 2013 Nov 11. [Epub ahead of print

42- B. M. Razavi1, H. Hosseinzadeh2, M. Imenshahidi1, M. Malekian1, M. Ramezani3, K. Abnous. Evaluation of Protein Ubiquitylation in Heart Tissue of Rats Exposed to Diazinon (an Organophosphate Insecticide) and Crocin (an Active Saffron Ingredient): Role of HIF-1α.  Drug Res (Stuttg). 2014 Nov 4. [Epub ahead of print]

43- Imenshahidi, M.aRazavi, B.M.bFaal, A.cGholampoor, A.cMousavi, S.M.cHosseinzadeh, H.dاین آدرس ایمیل توسط spambots حفاظت می شود. برای دیدن شما نیاز به جاوا اسکریپت داریدEffects of chronic crocin treatment on desoxycorticosterone acetate (doca)-salt hypertensive rats. Iranian Journal of Basic Medical Sciences Volume 17, Issue 1, January 2014, Pages 9-13

44- Imenshahidi, M.aAlipour, M.aHadizadeh, F.bاین آدرس ایمیل توسط spambots حفاظت می شود. برای دیدن شما نیاز به جاوا اسکریپت داریدMotamed-Shariaty, V.S  Hypotensive effect of a novel dihydropyridine with dual calcium channel blocking and angiotensin II antagonistic properties in a rat model. Pharmaceutical Sciences Volume 19, Issue 4, March 2014, Pages 135-138

 45- Bibi Marjan Razavi 1, Ebrahim Arasteh 1, Mohsen Imenshahidi 1, Mehrdad Iranshahi 2*Antihypertensive effect of auraptene, a monoterpene coumarin from the genus Citrus, upon chronic administration. Iranian Journal of Basic Medical Sciences

46- Mahmoud Hashemzaei1,2, Mohsen Imen Shahidi2, Seyyed Adel Moallem2, Khalil Abnous3, Maryam Ghorbani4 and Amir Hooshang Mohamadpour5. Modulation of JAK2, STAT3 and Akt1 proteins by granulocyte colony stimulating factor following carbon monoxide poisoning in male rat Drug Chem Toxicol, Early Online: 1–5  2016

47- Mitra Asgharian Rezaee a,b, Amir Hooshang Mohammadpour a,c, Mohsen Imenshahidi a, Mahmoud Mahmoudi d, Mojtaba Sankian e, Konstantinos Tsarouhas f, Andreas Tsakalof g, Aristidis Micheal Tsatsakis g, Seyed Adel Moallem. Protective effect of erythropoietin on myocardial apoptosis in rats exposed to carbon monoxide. Life Sciences 148 (2016) 118–124

48- Mohsen Imenshahidi and Hossein Hosseinzadeh. Berberis Vulgaris and Berberine: An Update. Phytother. Res. (2016)

49- Unused Medicines in Households Maliheh Dadgarmoghaddam,1 Mohsen Imenshahidi,2 Amin Aliabadi,2 Hakimeh Baseri,1 andMohammad Khajedaluee1,* Razavi Int J Med. 2016 March; 4(1):e34351.

50- The Relaxant Activity of Safranal in Isolated Rat Aortas is Mediated Predominantly via an Endothelium-Independent Mechanism: -Vasodilatory mechanism of safranal.  Journal of Pharmacopuncture

51- A review of the effects of berberis vulgaris and its major component, berberine, in metabolic syndrome. Iranian Journal of Basic Medical Sciences

Volume 20, Issue 5, May 2017, Pages 557-568

52- Manuscript Title: Histopathological study of erythropoietin protective effect on Carbon monoxide-induced cardiotoxicity in rat. Iranian Journal of Basic Medical SciencesOpen AccessVolume 20, Issue 11, November 2017, Pages 1189-119 Authors: Mitra Rezaee, mohsen imenshahidi, Adel Moallem, Amir Hooshang Mohammadpour, mahmoud mahmoudi, mojtaba sankian, hassan alavi, mahdi farzadnia

53- Evaluation of mechanism for antihypertensive and vasorelaxant effects of hexanic and hydroalcoholic extracts of celery seed in normotensive and hypertensive rats(Article)(Open Access)  Tashakori-Sabzevar, F.a,Razavi, B.M.b,Imenshahidi, M.c,Daneshmandi, M.a,Fatehi, Sarkarizi, Y.E.a, Mohajeri, S.A.c  Brazilian Journal of PharmacognosyOpen AccessVolume 26, Issue 5, September-October 2016, Pages 619-626

54- Razavi, B.M.a,  Alyasin, A.a, Hosseinzadeh, H.a,b, Imenshahidi, M.bاین آدرس ایمیل توسط spambots حفاظت می شود. برای دیدن شما نیاز به جاوا اسکریپت داریدSaffron induced relaxation in isolated rat aorta via endothelium dependent and independent mechanisms ranian Journal of Pharmaceutical ResearchOpen AccessVolume 17, Issue 3, Summer 2018, Pages 1018-1025

55- : Vitis vinifera (grape) seed extract and resveratrol alleviate bisphenol-A-induced metabolic syndrome: biochemical and molecular evidences. Phytotherapy Research

56- Khalil Abnous Soghra Mehri Leila Etemad Mohsen Imenshahidi Gholamreza Karimi. Oral deferiprone administration ameliorates cisplatin-induced nephrotoxicity in rats. J. Pharm Pharmacol. 2018. Pouran Makhdoumi

57- Effects of plant extracts and bioactive compounds on attenuation of bleomycin-induced pulmonary fibrosis Sarasadat Hosseinia, Mohsen Imenshahidib,c, Hossein Hosseinzadehb,c, Gholamreza Karimib,

58- Biofactors. 2018 Oct 19. doi: 10.1002/biof.1458. [Epub ahead of print] Protective effect of lycopene against chemical and natural toxins: A review. Hedayati N1Naeini MB2Nezami A1Hosseinzadeh H1,3Wallace Hayes A4,5Hosseini S1Imenshahidi M1,3Karimi G1,3.

59- Does granulocyte colony stimulating factor have protective effects against carbon monoxide-induced apoptosis? Hashemzaei, M.Mohammadpour, A.H.Imenshahidi, M.Rezaee, R.Moallem, S.A. 2018. Biologia. 73(11), pp. 1153-1157

60- Imenshahidi M, Hosseinzadeh H.Berberine and barberry Berberis vulgaris): A clinical review. Phytother Res. 2019 Jan 13. doi: 10.1002/ptr.6252. [Epub ahead of print] Review.

61- Vitis vinifera (grape) seed extract and resveratrol alleviate bisphenol-A-induced metabolic syndrome: biochemical and molecular evidences

63-  Preparation and Characterization of a Dry Powder Inhaler Composed of PLGA Large Porous Particles Encapsulating Gentamicin Sulfate Farideh Shiehzadeh1,2,3 , Mohsen Tafaghodi3* ID , Majid Laal-Dehghani1,2, Faezeh Mashhoori1,2, Bibi Sedigheh Fazly Bazzaz4,5 , Mohsen Imenshahidi6 ID ID  Adv Pharm Bull, 2019, 9(2), 255-261

64- The protective activity of nanomicelle curcumin in bisphenol A-induced cardiotoxicity following subacute exposure in rats

65- Rameshrad M1Imenshahidi M2Razavi BM3Iranshahi M4Hosseinzadeh H1. Bisphenol-A vascular toxicity: protective effect of Vitis vinifera (grape) seed extract and resveratrol. Phytother Res. 2018 Dec;32(12):2396-2407. doi: 10.1002/ptr.6175. Epub 2018 Aug 16.

66- Seyedeh Farzaneh Omidkhoda 1 , BiBi Marjan Razavi 2, 1, Mohsen Imenshahidi 1 , Maryam Rameshrad 3 , Hossein Hosseinzadeh 4, 1*Evaluation of possible effects of crocin against nitrate tolerance and endothelial dysfunction. Iran J Basic Med Sci, Vol. 23, No. , 2020

67-  Mohsen Imenshahidi1,2 & Golamreza Karimi1,2 & Hossein Hosseinzadeh1,2Effects of melatonin on cardiovascular risk factors and metabolic syndrome: a comprehensive review. Naunyn-Schmiedeberg's Archives of Pharmacology

68- Bagherpasand, N.a,Mehri, S.b,c,Shahroudi, M.J.a,Tabatabai, S.M.a,Khezri, A.a,Fathi, M.a,Abnous, K.bImenshahidi, M.a,Hosseinzadeh,  Effect of topiramate on morphine-induced conditioned place preference (Cpp) in rats: Role of erk and creb proteins in hippocampus and cerebral cortex. Iranian Journal of Pharmaceutical ResearchOpen AccessVolume 18, Issue 4, Autumn 2019, Pages 2000-2010

69- soudabeh balarastaghi, rezvan yazdian- robati, Faezeh vahdati hasani, Hossein Hosseinzadeh, Khalil Abnous, Mohsen Imenshahidi, leila mohammadzadeh, Ruth Birner-Gruenberger, Bibi Marjan Razavi. Protective effect of crocin on malathion-induced cardiotoxicity in rats: a biochemical, histopathological and proteomics study.. Bibi Marjan razavi