CURRICULUM VITAE

NAME: Hadi Afrasiabi Garekan

ADDRESS: School of Pharmacy, Mashhad University of Medical Sciences, P.O. Box:  17871   91886 , Mashhad, Iran

E-MAIL: این آدرس ایمیل توسط spambots حفاظت می شود. برای دیدن شما نیاز به جاوا اسکریپت دارید

POSITIONS HELD: Professor in Pharmaceutics (2007- now), Associate professor (2002-2007), Assistant professor (1997-2002), Mashhad University of Medical Science, School of Pharmacy

ACADEMIC QUALIFICATIONS: (1992-1996) Ph.D. in Pharmaceutical Technology, School of Pharmacy and Chemistry, Liverpool John Moores University, Liverpool, UK

(1984-1989) Doctoral course of pharmacy (Pharm. D.), School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Fellowship: Advanced training in the area of "Targeted liposomes". (November 2004- July 2005), under supervision of Professor Theresa Allen, University of Alberta, Edmonton, Canada

RESEARCH EXPRIENCES AND INTERESTS: 

-Modification of drug crystals to improve their physico-mechanical properties,

-Characterization of drug crystals using different techniques such as X-ray powder diffraction, thermal analysis, FTIR, SEM

-Investigation of the compression properties of drugs and excipients,

-Formulation of solid dosage forms,

-Design and development of solid dispersion systems in order to modify the drug release behavior,

-Design and development of colon delivery systems,

-Design and development of sustained release systems,

-Design and development of transdermal drug delivery systems,

-Tableting,

-Pelletization,

-Film coating,

-Microencapsulation,

Received awards:

Third Rank, Pharmaceutical research, 10th Medical sciences Research, Razi Festival, Tehran, Iran, 2005

First Rank, The Best Researcher Award, Mashhad University of Medical Sciences, Mashhad, Iran, 2003

The Mendel Award, for Scientific Excellence Research Paper: “Highly Compressible Paracetamol: Crystallization and Characterization” at 15th Pharmaceutical Technology Conference, Oxford, England, 19-21 March 1996

Translation of a Pharmaceutical book:

Translation of a book (from English to Persian):

Aulton’s Pharmaceutics, The Design and Manufacture of Medicines (Fourth Edition: 2013), Edited by: Michael E. Aulton and Kevin M.G. Taylor

Publications in International Journals:

1-Hadi Afrasiabi Garekani, Mona Faghihnia Torshizi, Fatemeh Sadeghi, Surelease as granulating liquid in preparation of sustained release matrices of ethylcellulose and theophylline.  Drug Development and Industrial Pharmacy, 41(2015), 1655-1660

2-Hadi Afrasiabi Garekani, Samira Sedighi, Fatemeh Sadeghi, Surelease or organic solution of ethylcellulose in preparation of sustained release theophylline micromatrices or matrices using spray drying technique. Pharm Dev Technol, 20 (2015) 204–210

3-Alireza Homayouni, Fatemeh Sadeghi, Jaleh Varshosaz, Hadi Afrasiabi Garekani, Preparation and Characterization of Celecoxib Dispersions in Soluplus^®: Comparison of Spray Drying and Conventional Methods. Iranian Journal of  Pharmaceutical Research 14 (2015) 35-50

4-Alireza Homayouni, Fatemeh Sadeghi, Jaleh Varshosaz, Hadi Afrasiabi Garekani, Ali Nokhodchi, Comparing various techniques to produce micro/nanoparticles for enhancing the dissolution of celecoxib containing PVP. European Journal of Pharmaceutics and Biopharmaceutics 88 (2014) 261-274

5-Alireza Homayouni, Fatemeh Sadeghi, Jaleh Varshosaz, Hadi Afrasiabi Garekani, Ali Nokhodchi, Promising dissolution enhancement effect of soluplus on crystallizedcelecoxib obtained through antisolvent precipitation and highpressure homogenization techniques. Colloids and surfaces B: Biointerfaces 122 (2014) 591-600

6-Alireza Homayouni, Fatemeh Sadeghi, Ali Nokhodchi, Jaleh Varshosaz, Hadi Afrasiabi Garekani, Preparation and characterization of celecoxib solid dispersions; comparison of poloxamer-188 and PVP-K30 as carriers, Iranian Journal of Basic Medical Sciences. 17 (2014) 322-331

7-Fatemeh Sadeghi, Mansour Torab, Mostafa Khattab, Alireza Homayouni, Hadi Afrasiabi Garekani, Development of partially amorphous acetaminophen via spray drying from hydroalcoholic solution: Improvement in physico-mechanical properties, Iranian Journal of Basic Medical Sciences. 16 (2013) 1100-1108

8-H. Afrasiabi Garekani, Z. Fatemi Moghaddam, F. Sadeghi., Organic solution versus aqueous dispersion of Eudragit RS in preparation of sustained release microparticles of theophylline using spray drying. Colloids and surfaces B: Biointerfaces 108 (2013) 374-379

9-Afrasiabi Garekani, H., Nokhodchi, A., Amirpour Rayeni, M, Sadeghi, F., Preparation and characterization and release properties of Eudragit RS based ibuprofen pellets prepared by extrusion spheronization. Effect of binder type and concentration. Drug Dev. Ind. Pharm. 39 (2013), 1238-1246 

10- Sadeghi, F., Shahabi, M., Afrasiabi Garekani, H. Comparison of physicomechanical properties of films prepared from organic solutions and aqueous dispersion of Eudragit RL. DARU 19(2) (2011)  100-106.

11- Sadeghi, F., Hijazi, H., Afrasiabi Garekani, H. Production of ibuprofen pellets containing high amount of rate retarding Eudragit RL using PEG400 and investigation of their physicomechanical properties.  Iranian Journal of Basic Medical Sciences. 14 (2011) 383-390.

12- Sadeghi F, Sanadgol E., Afrasiabi Garekani H. The effect of granulating liquid and curing on the physicomechanical and release properties of pellets containing ibuprofen and Eudragit RL prepared by extrusion spheronization. Pharmaceutical Sciences,  Journal of Faculty of Pharmacy, Tabriz University of Medical Sciences 17 (2011) 103-118.

13- Sadeghi F., Rakhshan M., Afrasiabi Garekani H. Preparation and evaluation of microcapsules containing propranolol hydrochloride using Eudragit polymers Pharmaceutical Sciences,  Journal of Faculty of Pharmacy, Tabriz University of Medical Sciences 17 ( 2011) 189 – 200.

14- Akhgari, A., Farahmand, F., Afrasiabi Garekani, H., Sadeghi, F., Vandamme, T.F. The effect of pectin on swelling and permeability characteristics of free films containing Eudragit RL and/or RS as a coating formulation aimed for colonic delivery. DARU 18 (2010) 91-96.

15- Akhgari, A., Afrasiabi Garekani, H., Sadeghi, F. Combination of inulin and time dependent polymethacrylates as a coating system to achieve colonic delivery of indomethacin. DARU 17 (2009) 199-208.

16- Sadeghi F., Oskooie R.K., Nasirli H., Afrasiabi Garekani H., 2009, Effect of granulation process on physicomechanical properties of granules and compaction behavior of hydroxypropyl methylcellulose with different degrees of methoxy/hydroxypropyl substitutes., Tabriz Journal of Pharmaceutical Sciences., 15, 93-102

17- Abbaspour, M.R., Sadeghi, F., Afrasiabi Garekani, H., Design and study of ibuprofen disintegrating sustained release tablets comprising coated pellets. Eur. J. Pharm. Biopharm. 68 (2008) 747-759.

18- Abbaspour, M.R., Sadeghi, F., Afrasiabi Garekani, H., Thermal treating as a tool to produce plastic pellets based on Eudragit RS PO and RL PO aimed for tableting. Eur. J. Pharm. Biopharm. 67 (2008) 260-267.

19- Ronald Ross Watson, Sherma Zibadi, Houshang Rafatpanah, Farahzad Jabbari, Ramin Ghasemi, Javad ghafari, Hadi Afrasiabi, Lai Yeap Foo, Reza Faridhosseini, 2008, Oral administration of purple passion fruit peel extract reduces wheeze and cough and improves shortness of breath in adults with asthma., Nutrition Research, 28, 166-171

20- Sadeghi F., Eidi M., Ansaripoor N., Afrasiabi Garekani H., 2008, Preparation and evaluation of microsphere containing diclofenac sodium and Eudragit RS or RL as oral sustained release multiparticulate delivery system., Tabriz Journal of Pharmaceutical Sciences., Spring, 9-18

21- Sadeghi, F., Mosaffa, F., Afrasiabi Garekani, H. Effect of particle size, compaction force and presence of aerosil 200 on the properties of matrices prepared from physical mixture of propranolol hydrochloride and Eudragit RS or RL.  Iranian Journal of Basic Medical Sciences. 10 (2007) 197-205.

22- Akhagri, A., Sadeghi, F., Afrasiabi Garekani, H. Combination of time-dependent and pH-dependent polymthacrylates as a single coating formulation for colonic delivery of indomethacin pellets. Int. J. Pharm. 320 (2006) 137-142.

23- Akhgari, A., Farahmand, F., Afrasiabi Garekani, H., Sadeghi, F., Vandamme, T.F., Permeability and swelling studies on free films containing inulin in combination with different polymethacrylates aimed for colonic drug delivery. Eur. J. Pharm. Sci. 28 (2006) 307-314.

24- Sadeghi, F., Afrasiabi Garekani H., Ghodsi A., 2006,  Evaluation of solid dispersion systems of acetaminophen and ethyl cellulose, eudragit RS or RL and the effect of solvent used in preparation of these systems on characteristics of matrices, Tabriz Journal of Pharmaceutical Sciences., Spring, 47-54

25- Abbaspour, M.R., Sadeghi, F., Afrasiabi Garekani, H., 2005, Effect of drug loading on physicomechanical and release properties of ibuprofen pellets prepared by extrusion-spheronization, Tabriz Journal of Pharmaceutical Sciences., 2, 55-64

27- Abbaspour, M.R., Sadeghi, F., Afrasiabi Garekani, H. Preparation and characterization of ibuprofen pellets based on Eudragit RS PO and RL PO or their combination. Int. J. Pharm., 303 (2005) 88-94.

28- Akhgari A., Afrasiabi Garekani, H., Sadeghi, F. and  Azimaie, M. Statistical optimization of indomethacin pellets coated with pH-dependent methacrylic polymers for possible colonic drug delivery. Int. J. Pharm.,305(2005)22-30.

29- Sadeghi, F., Afrasiabi Garekani, H., Goli, F. Tableting of Eudragit RS and propranolol hydrochloride solid dispersion: Effect of particle size, compaction force and plasticizer addition on drug release. Drug Dev. Ind. Pharm. 30 (2004) 759-766.

30- Afrasiabi Garekani, H., Sadeghi, F. Salary, M. 2004, Dissolution study of acetaminophen crystallized in the presence of polyvinylpyrrolidone., J. Drug Del. Sci. Tech. 14 (2004) 141-146.

31- Sadeghi, F., Afrasiabi Garekani, H., Sadr, A. Influence of polymer viscosity and plasticizer addition on ethylcellulose matrix characteristics prepared from solid dispersion system. S.T.P. PHARMA SCIENCE. 13 (2003) 105-110.

32- Sadeghi, F. Afrasiabi Garekani, H., Sadeghi, R. Comparison of ethylcellulose matrix characteristics prepared by solid dispersion technique or physical mixing. DARU, 11 (2003) 7-13.

33- Garekani, H.A., Sadeghi, F., Firouzpoor, A. The influence of propylene glycol and moisture on the compaction properties of acetaminophen granules. S.T.P. PHARMA SCIENCE. 13 (2003) 335-339.

34- Garekani, H.A., Sadeghi, F., Ghazi, A. Increasing the aqueous solubility of acetaminophen in presence of polyvinylpyrolidone and investigation of the mechanisms involved. Drug Dev. Ind. Pharm. 29 (2003) 173-179.

35- H. Afrasiabi Garekani, F. Sadeghi, A. Ghazi, 2002, Effect of polyvinylpyrrolidone on the aqueous solubility of acetaminophen and investigation of their interaction mechanisms, Iranian Journal of Basic Medical Sciences,  5, 53-58

36- F. Sadeghi, H. Afrasiabi Garekani, Z. Farzadnia, 2001, Effect of polymer viscosity, polymer particle size and compaction force on the diclofenac sodium release from ethyl cellulose matrices., Tabriz Journal of Pharmaceutical Sciences.,  Spring, 45-56

37- Garekani, H.A., Sadeghi, F., Badiee, A., Mostafa, S.A., Rajabi-Siahboomi, A.R. Crystal habit modifications of ibubrufen and their physicomechanical characteristics. Drug Dev. Ind. Pharm. 27 (2001) 803-809.

38- Hadi A. Garekani, James L. Ford, Michael H. Rubinstein, Ali R. Rajabi-Siahboomi, 2001. Effect of compression force, compression speed and particle size on the compaction properties of paracetamol., Drug Development and Industrial Pharmacy, 27, 935-942

39- H. Afrasiabi Garekani, F. Sadeghi, A. Firoozpour, 2000,The effect of moisture content on the compaction properties of acetaminophen granules and comparison with the effect of plasticizer., Iranian Journal of Basic Medical Sciences, 3, 113-122

40- Hadi A. Garekani, James L. Ford, Michael H. Rubinstein, Ali R. Rajabi-Siahboomi, 2000. Highly compressible paracetamol: I. Crystallization and characterization, International Journal of Pharmaceutics, 208, 87-99

41- Hadi A. Garekani, James L. Ford, Michael H. Rubinstein, Ali R. Rajabi-Siahboomi, 2000. Highly compressible paracetamol: II. Compression properties,  International Journal of Pharmaceutics, 208, 101-110

42- Hadi A. Garekani, James L. Ford, Michael H. Rubinstein, Ali R. Rajabi-Siahboomi, 1999. Formation and compression characteristics of prismatic polyhedral and thin plate-like crystals of paracetamol., International Journal of Pharmaceutics., 187, 77-89

43- H. Afrasiabi Garekani, F. Sadeghi, A. Badiee, 1999, Investigation of the physico-mechanical properties of modified crystals of ibuprofen., Iranian Journal of Basic Medical Sciences, 2,  8-17