فعالیتهای تحقیقاتی دکتر زهرا سلماسی

امتیاز کاربران

ستاره غیر فعالستاره غیر فعالستاره غیر فعالستاره غیر فعالستاره غیر فعال
 

In the name of God

Curriculum Vitae

 

Zahra Salmasi (Pharm.D., Ph.D.)

  Pharmaceutical nanotechnology; Assistant Professor

 

Address:

School of Pharmacy, Mashhad University of Medical Sciences, Mashhad-Iran

 

P.O. Box: 91775-1365  

Phone: ++98-51-31801-254, 09155103766

Fax: ++98-511-8823251  

E-mail: این آدرس ایمیل توسط spambots حفاظت می شود. برای دیدن شما نیاز به جاوا اسکریپت دارید ; این آدرس ایمیل توسط spambots حفاظت می شود. برای دیدن شما نیاز به جاوا اسکریپت دارید

 

Personal information:

 

Date of birth: 6/9/1980

Marital status: Married

Nationality: Iran

 

Education and training:

 

  • D. student: Department of Pharmaceutical Nanotechnology, Mashhad University of Medical Sciences, Iran (2009-2015)

 

Ph.D. supervisor: Dr.  Ramezani M., Dr.  Abnous Kh.

 

  • Research Field: Design and synthesis of nanoparticles, Targeted gene delivery by non-viral vectors in cancerous cells and Mesenchymal stem cells, Isolation, characterization and genetic engineering of Mesenchymal Stem Cells, Design of cellular vehicle in gene delivery to cancerous cells: Migration assay, Co-culture assay.

 

Ph.D. thesis: Novel PEI-based vectors for TRAIL Delivery to Mesenchymal Stem Cell for Cell-based Tumor suppression.

 

  • D. degree: School of pharmacy, Mashhad University of Medical Sciences, Iran (1998-2004)

 

Pharm. D. supervisor: Dr. Ramezani M., Dr. Behravan J.

Research Field: Biotechnology, Pharmacognosy

Pharm.D. thesis: Antiviral activity of Eupohrbia microsciadia percolation and soxhlet extracts.

 

Research interests

 

  • Design and synthesis of nanoparticles
  • New targeted drug delivery systems
  • Targeted gene delivery systems
  • Stem cells isolation and characterization
  • Application of stem cells in regenerative medicine
  • Scaffold preparation and application in cell culture and tissue engineering
  • Application of stem cells in targeted gene delivery
  • Application of stem cells in targeted drug delivery
  • In vivo research in the field of nanoparticles and stem cells

 

Publications and presentations

 

Papers and books

 

1) Heterocyclic amine-modified polyethylenimine as gene carriers for transfection of mammalian cells. Zahra Salmasi, Wayne Thomas Shier, Maryam Hashemi, Elahe Mahdipour, Hamideh Parhiz, Khalil Abnous, Mohammad Ramezani., European Journal of Pharmaceutics and Biopharmaceutics, 2015, 96; 76–88. (Impact factor: 4.245; 5-Year Impact Factor: 4.394)

 

2) Single-walled carbon nanotubes functionalized with aptamer and piperazine polyethylenimine derivative for targeted siRNA delivery into breast cancer cells. Marzieh Mohammadi and Zahra Salmasi, Maryam Hashemi, Fatemeh Mosaffa, Khalil Abnous, Mohammad Ramezani. International Journal of Pharmaceutics, 2015, 485; 50–60. (Impact factor: 3.650; 5-Year Impact Factor: 4.011)

 

3) Synthesis of efficient gene delivery systems by grafting pegylated alkylcarboxylate chains to PAMAM dendrimers: Evaluation of transfection efficiency and cytotoxicity in cancerous and mesenchymal stem cells. Sara Ayatollahi, Maryam Hashemi, Reza Kazemi Oskuee, Zahra Salmasi, Ahad Mokhtarzadeh, Mona Alibolandi, Khalil Abnous and Mohammad Ramezani. Journal of Biomaterials Applications, 2015, 11. (Impact Factor: 2.197)

 

4) Alkylcarboxylate Polyethylenimine-grafted Chitosans as Efficient Gene Vectors with Improved Gene Delivery Activity. Hamideh Parhiz, Fezzeh Memari, Sara Amel Farzad, Maryam Hashemi, Zahra Salmasi, Behzad Behnam and Mohammad Ramezani, Current Nanoscience, 2013,9; 717-722. (Impact Factor: 1.422)

 

5) Euphorbia Microsciadia Percolation and Soxhlet Extracts Exhibit Antiviral Activity. Zahra Salmasi, Mohammad Ramezani, Zahra Sabeti noghabi and Javad Behravan. Pharmacologyonline, 2011, 1; 910-920. (Indexed in Scopus)

 

6) Aptamer-targeted delivery of Bcl-xL shRNA using alkyl modified PAMAM

dendrimers into lung cancer cells. Sara Ayatollahi, Zahra Salmasi, Maryam Hashemi, Saeedeh Askarian, Reza Kazemi Oskuee, Khalil Abnous, Mohammad Ramezani. International Journal of Biochemistry and Cell Biology, 2017, 210-217 (Impact Factor: 3.55)

 

7) Fabrication of hybrid scaffold based on hydroxyapatite-biodegradable nanofibers incorporated with liposomal formulation of BMP-2 peptide for bone tissue engineering, Marzieh Mohammadi; Mona Alibolandi; Khalil Abnous; Zahra Salmasi; Mahmoud Reza Jaafari; Mohammad Ramezani. Nanomedicine: Nanotechnology, Biology, and Medicine, 2018  (Impact Factor: 5.72)

 

8) Effective and safe in vivo gene delivery based on polyglutamic acid complexes with heterocyclic amine modified-polyethylenimine, Zahra Salmasi; Ahad Mokhtarzadeh; Maryam Hashemi; Mahboubeh Ebrahimian; Sara Amel Farzad; Mohammad Ramezani, Ph.D; Hamideh Parhiz, Colloids and Surfaces B: Biointerfaces, 2018 (under review)( Impact Factor: 3.88)

 

9) Exosomes derived from TRAIL-engineered mesenchymal stem cells with effective anti-tumor activity in a mouse melanoma model, Fazileh Hosseini Shamili; Houshang Rafatpanah Bayegi; Zahra Salmasi; Kayvan Sadri; Mahmoud Mahmoudi; Mahmoudreza Kalantari; Mohammad Ramezani, Ph.D; Khalil Abnous, International Journal of Pharmaceutics, 2018 (under review)( Impact Factor: 3.649)

 

10) Potential of stem cellderived exosomes to regenerate β islets through Pdx1 dependent mechanism in a rat model of type 1 diabetes, Mahdipour ESalmasi Z,
Sabeti N, Journal of cellular physiology, 2018.

 

11) Mesenchymal stem cells engineered by modified polyethylenimine polymer for targeted cancer gene therapy, in vitro and in vivo, Zahra Salmasi, Maryam Hashemi, Elahe Mahdipour, Hossein Nourani, Khalil Abnous, Mohammad Ramezani, Biotechnology progress, 2019 (under review)( Impact Factor: 2.406)

 

12) book entitled "Nanomedicine: Advanced Nanoparticles and their application in Pharmacy and Medicine". 2018.

           

Research Projects

PhD thesis entitled "Novel PEI-based vectors for TRAIL Delivery to Mesenchymal Stem Cell for Cell-based Tumor suppression"(Code 900140).

 

Cooperationin performingthe thesisas the adviser entitled "Targeted delivery of siRNA to induce cell death in colon cancer stem cells using carbon nanotube-aptamer conjugate" (Code 900589).

 

Cooperationin performingthe PhD thesis entitled"Transfer Effect of exosomes aptamer and the immune system in the mouse model of multiple sclerosis process" (Code 930926).

 

Cooperationin performingthe PhD thesis entitled "Electro-spined nanofibers containing BMP2-encapsulated liposomes to promote osteogenic differentiation"
(Code 931455).

Cooperationin performingthe research project entitled"The effect of poly-glutamic acid on gene delivery properties of polyethylenimine (PEI) modified with heterocyclic amine" (Code 921897).

 

 

Cooperationin performingthe research project entitled"A Comparative study of progestrone and 17_a_Hydroxyprogestron coproate for luteal phase support in patient undergoing IUI cycles" (Code 86092, 2007).

Design and synthesis of targeted polymeric nanoparticles for codelivery of mitoxantrone and curcumin for effective elimination of breast cancer cells' (Code 961941, 2018).

انتقال ژن اینترلوکین 12 به سلول بنیادی با استفاده از حامل هیدروکسی آپاتیت و دندرایمر پامام اصلاح شده با پپتید نفوذ کننده به سلول و استفاده از این سلول بنیادی مهندسی شده جهت درمان سرطان کولون در مدل موشی (961464، 1397)

بررسی اثرات محافظتی استفاده همزمان سلولهای بنیادی مشتق از پالپ دندان انسان و G-CSF در آسیب عصبی ناشی ازهیپوکسی بر روی رده سلولیُSHSY5Y (960882، 1396)

سنتز و تهیه اسکافولدهای کلاژنی هیبریدی حاوی نانوپارتیکلهای رسوراتول جهت تمایز سلولهای بنیادی مزانشیمال به سلولهای استخوانی (960788، 1396)

بررسی انتقال تیموکینون توسط اگزوزوم های حاصل از سلول های بنیادی مزانشیمال انسانی جهت سرکوب سلول های سرطان سینه ( 961956)

ایجاد سیتوتوکسیسیتی در سلول های گلیوبلاستومای مقاوم به TRAIL به کمک سلول های بنیادی مهندسی شده توسط ژن TRAIL و نانوذرات مبتنی بر PLGA بارگیری شده با داروی میتوکسانترون

 

انتقال هدفمند داروی ضد تومور به سلول های تومور توسط سلولهای بنیادی مزانشیمال مهندسی شده با نانوذرات حاوی دارو

بررسی میزان اثربخشی اگزوزوم های مهندسی شده حاوی توالی نوکلئوتیدی در سرکوب تومور

 

بازسازی سلولهای تولید کننده انسولین با استفاده از نانووزیکولهای مترشحه از سلولهای بنیادی مزانشیمی در مدل حیوانی دیابت نوع 1

 

تهیه و ارزیابی نانوژل کیتوزان حاوی عصاره گیاه تاجریزی (Solanum nigrum جهت استفاده در پانسمان زخم

 

مقایسه اثرات محافظتی استفاده همزمان سلولهای بنیادی مشتق از پالپ دندان و سلول های بنیادی مشتق چربی ازانسان در آسیب عصبی ناشی ازهیپوکسی بر روی رده سلولیSHSY5Y

 

طراحي و ساخت داربست هاي هيبريدي کلاژن-هيدروکسي آپاتيت داراي نانوپارتيکل هاي سيليکاي حاوي نارينجين براي بهبود تمايز سلولهاي بنيادي مزانشيمال به سلولهاي استخواني (985016)

 

تهيه و تعيين خصوصيات نانوذرات ليپيدي جامد هدفمند شده با آپتامر EpCAM حاوي شيکونين به منظور حذف موثر سلولهاي سرطاني ( 985023)

 

Conducting the academic workshop

 

  • Conducting the workshop entitled “Isolation and characterization of mesenchymal stem cells from mice bone marrow and adipose tissue and differentiation into osteoblasts and adipocytes” in School of Pharmacy of Mashhad, 2015 and also 2017.

Research awards

 

  • Topposteraward in International congress on stem cells and regenerative medicine, Mashhad, 2015, Iran for poster entitled “Novel polyethylenimine-based vectors for gene delivery to mesenchymal stem cells for cell-based tumor migration and suppression”.

  • TopPosterAward at the 3th Festival of Postgraduate Research

 

Conference Oral Presentations

 

1) "The Synergistic Effect of different heterocyclic amino groups on Gene Transfection Efficiency of Polyethylenimine". 13th Iranian Pharmaceutical Sciences Congress (IPSC 2012), Isfahan, Iran.

 

2) "Mesenchymal stem cell in cell-based gene delivery". School of Pharmacy, Mashhad University of Medical Sciences, 2010, Iran.

 

Conference Poster Presentations

 

1) "Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles". Nanodrugs, Nanobiotechnology, Nanosensors and Nanomaterials in medical sciences, Mashhad, 2009, Iran.

2) "Euphorbia microsciadia percolation and soxhlet extract exhibit antiviral activity". 12th Iranian congress of biochemistry and 4th International congress of biochemistry and molecular biology, Mashhad, 2011, Iran.

3) "Cell-based vehicles in cancer gene therapy". 5th International controlled release conference of Iran (ICRC 2011), Mashhad, 2011, Iran.

4) "Isolation and characterization of mesenchymal stem cells and evaluation of gene transfection efficiency of different heterocyclic- decorated polyethylenimine". 6th Iranian controlled release society conference (ICRC 2014), Tehran, 2014, Iran.

5) " Novel polyethylenimine-based vectors for gene delivery to mesenchymal stem cells for cell-based tumor migration and suppression". International congress on stem cells and regenerative medicine, Mashhad, 2015, Iran.
(Top Poster Award)

6) Actively attended and participated in the “13th Iranian Pharmaceutical Sciences Congress (IPSC2012)”, Isfahan, 2012.

7) Poster presentations at the 2th, 3th, 4th and 5th Festival of Postgraduate Research Students (Top Poster Award at the 3th festival).

 8) Participate in the Iranian Congress on "Biology and applicationof of stem cells", Mashhad, 2011 for 3 days.

 9) Participate in the first National Congress "acrylamide and its challenges in the food industry" 2010, Mashhad.

10) Participate in the conference "stem cells therapy", 2010, Mashhad.

11) Participate in the second "National Congress of Research and Application of Stem Cell” 2014, Mashhad.

12)  Participate in the first congress of "Research and Clinical Application of Stem Cell” 2012, Mashhad.

13)  Participate in the scientific conference of "The role of medical therapy in male infertility", Montaserieh Hospital, 2007, Mashhad.

14) Participate in the scientific conference of "Gamete and embryo donation", Montaserieh Hospital, 2007, Mashhad.

 

Workshops

 

1) The 5th Royan International Summer School: Stem cell and developmental biology for regeneration medicine, Tehran (2014, 6 days).

 2) Stem cell technology research center summer school and its workshops on (2014, 5 days):

 

- Principles of animal cell culture

- Expansion of Induced Pluripotent Stem Cells (IPS)

- Lentiviral gene packaging and transduction of IPS

- Gene transfer by pronulear microinjection

- Nano-structure scaffold preparation and stem cell culture

 

3) "Preparation of mesenchymal stem cells derived from bone marrow, umbilical cord blood and adipose tissue" , Iranian Congress on Biology and Application of Stem Cell, Mashhad, 2011 (2 day).

4) "Real time PCR", School of Pharmacy, Mashhad University of Medical Sciences, 2012 (2 days).

5) "Western Blot", School of Pharmacy, Mashhad University of Medical Sciences, 2012 (2 days).

6) "Patent Workshop". 6th Iranian controlled release society conference (ICRC 2014), Tehran.

7) "Business Planning Workshop". 6th Iranian controlled release society conference (ICRC 2014), Tehran.

8) "Scientific Writing" as a part of 5th International "Controlled Release Conference" (ICRC 2011), 2011, Mashhad.

9) "Scientific Writing".School of Nursing and Midwifery, Mashhad University of Medical Sciences, 2013 (3 days).

10) "Review the basics of writing scientific papers".School of Nursing and Midwifery, Mashhad University of Medical Sciences, 2013 (3 days).

11) "Basic Concepts of Flow cytometry". Avicenna Research Institute. Mashhad University of Medical Sciences, Mashhad, 2010 (1 day).

12) "Systematic review", School of Pharmacy, Mashhad University of Medical Sciences, 2012 (1 day).

13) "Advanced Excel", School of Pharmacy, Mashhad University of Medical Sciences, 2010 (1 day).

14) "Practical tools of Google", School of Pharmacy, Mashhad University of Medical Sciences, 2010 (1 day).

 

Other activities

 

  • Participation in Referees Committee Conferences of :
  • The 5th Iranian controlled release conference (ICRC 2011)
  • The 8th Student Conference on Nanotechnology, 2010
  • Cooperation with Iranian Journal of Basic Medical Sciences.