فعالیتهای تحقیقاتی دکتر زهرا سلماسی

امتیاز کاربران

ستاره غیر فعالستاره غیر فعالستاره غیر فعالستاره غیر فعالستاره غیر فعال
 

In the name of God

Curriculum Vitae

 

Zahra Salmasi (Pharm.D., Ph.D.)

  UPh.D. of pharmaceutical nanotechnology

 

Address:

School of Pharmacy, Mashhad University of Medical Sciences, Mashhad-Iran

P.O. Box: 91775-1365

Phone: ++98-51-31801254

Fax: ++98-51-8823251

E-mail: این آدرس ایمیل توسط spambots حفاظت می شود. برای دیدن شما نیاز به جاوا اسکریپت دارید ; این آدرس ایمیل توسط spambots حفاظت می شود. برای دیدن شما نیاز به جاوا اسکریپت دارید

 

Personal information:

 

Date of birth: 6/9/1980

Marital status: Married

Nationality: Iran

 

Education and training:

  • Ph.D. student: Department of Pharmaceutical Nanotechnology, Mashhad University of Medical Sciences, Iran (2009 up to now)

 

Ph.D. supervisor: Dr.  Ramezani M., Dr.  Abnous Kh.

Research Field: Nanoparticle synthesis, Targeted gene delivery by non-viral vectors in cancerous cells and Mesenchymal stem cells, Isolation, characterization and genetic engineering of Mesenchymal Stem Cells, Design of cellular vehicle in gene delivery to cancerous cells: Migration assay, Co-culture assay.

 

Ph.D. thesis: Novel PEI-based vectors for TRAIL Delivery to Mesenchymal Stem Cell for Cell-based Tumor suppression.

  • Pharm. D. degree: School of pharmacy, Mashhad University of Medical Sciences, Iran (1998-2004)

 

Pharm. D. supervisor: Dr. Ramezani M., Dr. Behravan J.

Research Field: Biotechnology, Pharmacognosy

Pharm.D. thesis: Antiviral activity of Eupohrbia microsciadia percolation and soxhlet extracts.

 

Research interests

  • Design and synthesis of nanoparticles
  • New targeted drug delivery systems
  • Stem cells isolation and characterization
  • Application of stem cells in targeted drug delivery
  • Application of stem cells in targeted gene delivery
  • Application of stem cells in regenerative medicine
  • Scaffold preparation and application in cell culture and tissue engineering
  • Tissue engineering
  • Targeted gene delivery systems
  • In vivo research in the field of nanoparticles and stem cells

 

Publications and presentations

Papers

 

1) Heterocyclic amine-modified polyethylenimine as gene carriers for transfection of mammalian cells. Zahra Salmasi, Wayne Thomas Shier, Maryam Hashemi, Elahe Mahdipour, Hamideh Parhiz, Khalil Abnous, Mohammad Ramezani., European Journal of Pharmaceutics and Biopharmaceutics, 2015, 96; 76–88. (Impact factor: 4.245; 5-Year Impact Factor: 4.394)

2) Single-walled carbon nanotubes functionalized with aptamer and piperazine polyethylenimine derivative for targeted siRNA delivery into breast cancer cells. Marzieh Mohammadi and Zahra Salmasi, Maryam Hashemi, Fatemeh Mosaffa, Khalil Abnous, Mohammad Ramezani. International Journal of Pharmaceutics, 2015, 485; 50–60. (Impact factor: 3.650; 5-Year Impact Factor: 4.011)

3) Synthesis of efficient gene delivery systems by grafting pegylated alkylcarboxylate chains to PAMAM dendrimers: Evaluation of transfection efficiency and cytotoxicity in cancerous and mesenchymal stem cells. Sara Ayatollahi, Maryam Hashemi, Reza Kazemi Oskuee, Zahra Salmasi, Ahad Mokhtarzadeh, Mona Alibolandi, Khalil Abnous and Mohammad Ramezani. Journal of Biomaterials Applications, 2015, 11. (Impact Factor: 2.197)

4) Alkylcarboxylate Polyethylenimine-grafted Chitosans as Efficient Gene Vectors with Improved Gene Delivery Activity. Hamideh Parhiz, Fezzeh Memari, Sara Amel Farzad, Maryam Hashemi, Zahra Salmasi, Behzad Behnam and Mohammad Ramezani, Current Nanoscience, 2013,9; 717-722. (Impact Factor: 1.422)

5) Euphorbia Microsciadia Percolation and Soxhlet Extracts Exhibit Antiviral Activity. Zahra Salmasi, Mohammad Ramezani, Zahra Sabeti noghabi and Javad Behravan. Pharmacologyonline, 2011, 1; 910-920. (Indexed in Scopus)

 

Unpublished articles and book

1) Novel PEI-based vectors for TRAIL Delivery to Mesenchymal Stem Cells for Cell-based Tumor suppression. Zahra Salmasi, Maryam Hashemi, Elahe Mahdipour, Sara Ayatollahi, Khalil Abnous, Mohammad Ramezani.

2) Targeted polyamidoamine (PAMAM) dendrimers conjugated to polyethylene glycol aptamer as nanoparticles for gene silencing to lung cancer.
Sara Ayatollahi, Maryam Hashemi, Reza Kazemi Oskuee, Zahra Salmasi, Ahad Mokhtarzadeh, Khalil Abnous and Mohammad Ramezani.

3) Poly (α-glutamic acid) coated vector for effective and safe gene delivery in vitro and in vivo. Zahra Salmasi, Maryam Hashemi, Hamideh Parhiz, Sara Ayatollahi, Mohammad Ramezani.

4) Co-authored in book entitled "Nanomedicine: Advanced nanomaterials and their applications in medicine and pharmaceutics". Print of this book is going through administrative procedures.

 

Research Projects

1- PhD thesis entitled "Novel PEI-based vectors for TRAIL Delivery to Mesenchymal Stem Cell for Cell-based Tumor suppression"(Code 900140).

2- Cooperation in performing the thesis as the adviser entitled "Targeted delivery of siRNA to induce cell death in colon cancer stem cells using carbon nanotube-aptamer conjugate" (Code 900589).

3-Cooperation in performing the PhD thesis entitled "Synthesis and in vitro characterization of targeted poliamidoamine (PAMAM)-based dendrimers conjugated to aptamer as nanoparticles for gene delivery".

4- Cooperation in performing the PhD thesis entitled "Transfer Effect of exosomes aptamer and the immune system in the mouse model of multiple sclerosis process" (Code 930926).

5- Cooperation in performing the PhD thesis entitled "Electro-spined nanofibers containing BMP2-encapsulated liposomes to promote osteogenic differentiation"
(Code 931455).

6- Cooperation in performing the research project entitled “Targeting delivery of Epirubicin aptamer conjugated nanoparticles to cancer cells”.

7- Cooperation in performing the research project entitled "The effect of poly-glutamic acid on gene delivery properties of polyethylenimine (PEI) modified with heterocyclic amine" (Code 921897).

8- Cooperation in performing the research project entitled "Targeted delivery of Irinotecan to colorectal cancer cells using PLGA-PEG-Aptamer complexes" (Code 930480).

9- Cooperation in performing the research project entitled "A Comparative study of progestrone and 17_a_Hydroxyprogestron coproate for luteal phase support in patient undergoing IUI cycles" (Code 86092, 2007).

 

Conducting the academic workshop

- Conducting the workshop entitled “Isolation and characterization of mesenchymal stem cells from mice bone marrow and adipose tissue and differentiation into osteoblasts and adipocytes” in School of Pharmacy of Mashhad, 2015.

 

Research awards

- Second place in PhD entrance exam.

-  Second place in the board exam.

- Top poster award in International congress on stem cells and regenerative       medicine, Mashhad, 2015, Iran for poster entitled “Novel polyethylenimine-based vectors for gene delivery to mesenchymal stem cells for cell-based tumor migration and suppression”

- Top Poster Award at the 3th Festival of Postgraduate Research Students.

- Attendance in "4th student ideas seminar in the field of stem cells" and my idea as "Mesenchymal stem cells as targeted cell vehicle for anti-cancer drug delivery loaded with nanoparticles " was selected among the top twenty ideas from 122 ideas.

- Second place in presence in school of pharmacy in 1389/4.

 

Conference Oral Presentations

 

1) "The Synergistic Effect of different heterocyclic amino groups on Gene Transfection Efficiency of Polyethylenimine". 13th Iranian Pharmaceutical Sciences Congress (IPSC 2012), Isfahan, Iran.

2) "Mesenchymal stem cell in cell-based gene delivery". School of Pharmacy, Mashhad University of Medical Sciences, 2010, Iran.

3) Attendance in "4th student ideas seminar in the field of stem cells" and my idea as "Mesenchymal stem cells as targeted cell vehicle for anti-cancer drug delivery loaded with nanoparticles " was selected among the top twenty ideas from 122 ideas.

 

Conference Poster Presentations

1) "Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles". Nanodrugs, Nanobiotechnology, Nanosensors and Nanomaterials in medical sciences, Mashhad, 2009, Iran.

2) "Euphorbia microsciadia percolation and soxhlet extract exhibit antiviral activity". 12th Iranian congress of biochemistry and 4th International congress of biochemistry and molecular biology, Mashhad, 2011, Iran.

3) "Cell-based vehicles in cancer gene therapy". 5th International controlled release conference of Iran (ICRC 2011), Mashhad, 2011, Iran.

4) "Isolation and characterization of mesenchymal stem cells and evaluation of gene transfection efficiency of different heterocyclic- decorated polyethylenimine". 6th Iranian controlled release society conference (ICRC 2014), Tehran, 2014, Iran.

5) " Novel polyethylenimine-based vectors for gene delivery to mesenchymal stem cells for cell-based tumor migration and suppression". International congress on stem cells and regenerative medicine, Mashhad, 2015, Iran.
(Top Poster Award)

6) Actively attended and participated in the “13th Iranian Pharmaceutical Sciences Congress (IPSC2012)”, Isfahan, 2012.

7) Poster presentations at the 2th, 3th, 4th and 5th Festival of Postgraduate Research Students (Top Poster Award at the 3th festival).

 8) Participate in the Iranian Congress on "Biology and applicationof of stem cells", Mashhad, 2011 for 3 days.

 9) Participate in the first National Congress "acrylamide and its challenges in the food industry" 2010, Mashhad.

10) Participate in the conference "stem cells therapy", 2010, Mashhad.

11) Participate in the second "National Congress of Research and Application of Stem Cell” 2014, Mashhad.

12)  Participate in the first congress of "Research and Clinical Application of Stem Cell” 2012, Mashhad.

13)  Participate in the scientific conference of "The role of medical therapy in male infertility", Montaserieh Hospital, 2007, Mashhad.

14) Participate in the scientific conference of "Gamete and embryo donation", Montaserieh Hospital, 2007, Mashhad.

 

Workshops

1) The 5th Royan International Summer School: Stem cell and developmental biology for regeneration medicine, Tehran (2014, 6 days).

 2) Stem cell technology research center summer school and its workshops on (2014, 5 days):

- Principles of animal cell culture

- Expansion of Induced Pluripotent Stem Cells (IPS)

- Lentiviral gene packaging and transduction of IPS

- Gene transfer by pronulear microinjection

- Nano-structure scaffold preparation and stem cell culture

3) "Preparation of mesenchymal stem cells derived from bone marrow, umbilical cord blood and adipose tissue" , Iranian Congress on Biology and Application of Stem Cell, Mashhad, 2011 (2 day).

4) "Real time PCR", School of Pharmacy, Mashhad University of Medical Sciences, 2012 (2 days).

5) "Western Blot", School of Pharmacy, Mashhad University of Medical Sciences, 2012 (2 days).

6) "Patent Workshop". 6th Iranian controlled release society conference (ICRC 2014), Tehran.

7) "Business Planning Workshop". 6th Iranian controlled release society conference (ICRC 2014), Tehran.

8) "Scientific Writing" as a part of 5th International "Controlled Release Conference" (ICRC 2011), 2011, Mashhad.

9) "Scientific Writing".School of Nursing and Midwifery, Mashhad University of Medical Sciences, 2013 (3 days).

10) "Review the basics of writing scientific papers".School of Nursing and Midwifery, Mashhad University of Medical Sciences, 2013 (3 days).

11) "Basic Concepts of Flow cytometry". Avicenna Research Institute. Mashhad University of Medical Sciences, Mashhad, 2010 (1 day).

12) "Systematic review", School of Pharmacy, Mashhad University of Medical Sciences, 2012 (1 day).

13) "Advanced Excel", School of Pharmacy, Mashhad University of Medical Sciences, 2010 (1 day).

14) "Practical tools of Google", School of Pharmacy, Mashhad University of Medical Sciences, 2010 (1 day).

 

Other activities

 

- Participation in Referees Committee Conferences of :

- The 5th Iranian controlled release conference (ICRC 2011)

- The 8th Student Conference on Nanotechnology, 2010

-  Cooperation with Iranian Journal of Basic Medical Sciences.