فعالیتهای تحقیقاتی دکتر سید عادل معلم

امتیاز کاربران

ستاره غیر فعالستاره غیر فعالستاره غیر فعالستاره غیر فعالستاره غیر فعال
 
   

 

 
Name: Seyed Adel Moallem, PharmD, PhD
Professor
Languages: Fluent in Persian, English, Arabic; French (fair)
Address: Department of Pharmacology & Toxicology
School of pharmacy
P.O.Box 91775-1365
Mashhad Iran
Tel: +98-511-8823255 +98-511-8823255 Fax:+98-511-8823251
Email:این آدرس ایمیل توسط spambots حفاظت می شود. برای دیدن شما نیاز به جاوا اسکریپت دارید; این آدرس ایمیل توسط spambots حفاظت می شود. برای دیدن شما نیاز به جاوا اسکریپت دارید
 

Education

  • Ph.D in Pharmacology and Toxicology(Dean's Honor List, 1998): Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada.
  • Pharm.D(Top graduate, 1988): School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Positions

  • Head of Department of Pharmacology & Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran, 2002-2004; 2010-2012.
  • Member of Research Council, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran, 2002- 2006
  • Director of Toxicology Laboratory, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran, 2002
  • Director of Library, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran, 2000- 2004
  • Director of Developmental Toxicology & Teratology Laboratory, Pharmaceutical Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran, 2000-
  • Directorof Research Affairs, Mashhad University of Medical Sciences, Mashhad, Iran, 2000-2001
  • Member of the High Councils of the "Pharmaceutical Sciences Research Center" & the "Medical Toxicology Research Center".

Research Interests

  • Molecular teratogenesis and role of genetics, gene expression and apoptosis in teratogens’ effects.
  • Stem cell molecular biology and epigenetics; peritoneal stem cell differentiation.
  • Molecular toxicology and teratology of drugs and medicinal herbs at molecular, morphological and also mechanistic levels.
  • Ethnopharmacology, pharmacology of folklore and traditional medicine, particularly medicinal herbs.
  • Teratology of common medicinal herbs: morphological and molecular aspects.

Membership

  • “American Society for Pharmacology and Experimental Therapeutics”,Bethesda, Maryland, USA. February 1998-
  • “The Teratology Society”, Bethesda, Maryland, USA. July 1997- (member of the Membership Committee, 2009- )
  • “Society of Toxicology”, Washington, D.C., USA. March 1994-
  • “Pharmacological Society of Canada”, March 1994-
  • "Medical Order of Iran", Tehran, Iran. July 1989-
  • "Khorasan Pharmacists Society", Mashhad, Iran. July 1987-

Awards

  • Student Travel Awards, Teratology Society, Baltimore, MD, USA. June 1996 and June 1997.
  • McGill Major Fellowship Award, McGill University, Montréal, Canada. September 1995 - August 1996. Renewed for the year September 1996-August 1997.
  • Faculty of Medicine Studentship Award,McGill University, Montréal, Canada. July 1994 -August 1995.
  • Student Travel Award,Society of Toxicology, Washington, DC, USA. March 1994.
  • James Frosst Fellowship, Department of Pharmacology and Therapeutics, McGill University, Montréal, Canada. July 1993 - June 1994.
  • "Outstanding Researcher" at Mashhad University of Medical Sciences. 2008 & 2012.

Selected Publications

- Etemad L, AH Jafarian, SA Moallem. Pathogenesis of Pregabalin-Induced Limb Defects in Mouse Embryos. J Pharm Pharm Sci 18 (5):863-870 (2015).
 
- Afshar M, B. Ravarian, M. Zardast, SA Moallem, M. Hasanpour Fard, M. Valavi. Evaluation of cutaneous wound healing activity of Malva sylvestris aqueous extract in Balb/C mice. Iranian Journal of Basic Medical Sciences 18:616-622 (2015).
- Moallem SA, AH Mohamadpour, K Abnous, M Sankian, HR Sadeghnia, A Tsatsakis, S Shahsavand. Erythropoietin in the treatment of monoxide neurotoxicity in rat. Food and Chemical Toxicology 86: 56-64 (2015).
 
- Oskouei Z, L Etemad, SA Moallem, N Vahdati-Mashhadian, H Hosseinzadeh. Teratogenic Effect of Lippia citriodora Leaves Aqueous Extract in Mice. Avicenna Journal of Phytomedicine. Epub (2015).
 
- Gholami M, SA Moallem, M Afshar, L Etemad, G Karimi. Maternal exposure to Silymarin leads to pathological changes in mouse foetuses. Pharmacology Online 2:38-43 (2015).
 
- Iman M., SA Moallem, A Barahoyee. Effect of apple cider vinegar on blood glucose level in diabetic mice. Pharmaceutical Sciences 20: 163-168 (2015).
 
- Etemad L., R. Zafari, N. Vahdati-Mashhadian, SA Moallem, Z.O. Shirvan, H. Hosseinzadeh. Acute, sub-acute and cell toxicity of Verbascoside. Research Journal of Medicinal Plant 9(7): 354-360 (2015).
 
- Etemad L, R. Zafari, SA Moallem, N. Vahdati-Mashhadian, Z.S. Oskouei, H. Hosseinzadeh. Teratogenic effect of Verbascoside, main constituent of Lippia citriodora leaves, in mice. Iranian Journal of Pharmaceutical Research (in press).
 
- Moallem SA, N. Dehghani, S. Mehri, S. Shahsavand, M. Alibolandi, F. Hadizadeh. Synthesis of novel 1, 8-acridinediones derivatives: investigation of MDR reversibility on breast cancer cell lines T47D and tamoxifen-resistant T47D. Research in Pharmaceutical Sciences 10 (3): 214-221 (2014).
 
- Afshar M, MM Hassanzadeh Taheri, SA Moallem, MJ Golalipour, M Shahsavan. Fetal malformations due to long term consumption of sodium benzoate in pregnant Balb/c mice. Asian Journal of Pharmacology and Toxicology. 2 (6): 1-7 (2014).
 
- Afshar M, B. Ravarian, M. Zardast, SA Moallem, M. Hasanpour Fard, M. Valavi. Evaluation of cutaneous wound healing activity of Malva sylvestris aqueous extract in Balb/C mice. Iranian Journal of Basic Medical Sciences 18:616-622 (2015).
 
- Moallem SA, A. Timcheh-Hariri, M. Mahmoudi, H. Hosseinzadeh. Effect of aqueous extract of Crocus sativus L. (saffron) stigma against subacute effect of diazinon on specific biomarkers in rats. Toxicology and Industrial Health 30 (2):141-146 (2014).
 
- Mohammadpour AH, SA Moallem, M Bafandegan, J Shamsara, F Nazemian. Effects of omega-3 administration on homocysteine serum concentration in renal transplant recipients. Journal of Pharmaceutical Care 1:25-28 (2013).
 
- Etemad L, M Afshar, AH Mohammadpour, N Vahdati Mashhadi, SA Moallem. Teratogenic effects of pregabalin in mice. Iranian Journal of Basic Medical Sciences 16:1065-1070 (2013).
 
- Moallem SA, M Imenshahidi, N Shahini, AR Javan, M Karimi, M Alibolandi, M Ghandadi, L Etemad, V Motamedshariaty, F Hadizadeh. Synthesis, anti-inflammatory and anti-nociceptive activities and in vitro antitumor effect of novel thiazolidin 4-ones derivatives as selective cyclooxygenase (COX-2) inhibitors. Iranian Journal of Basic Medical Sciences 16:1238-1244 (2013).
 
- Moallem SA, M Afshar, L Etemad, BM Razavi, H Hosseinzadeh. Evaluation of teratogenic effects of crocin and safranal, active ingredients of saffron, in mice. Toxicology and Industrial Health; published online 4 Oct 2013; PMID: 24097366.
 
- Afshar M, SA Moallem, J Khayatzadeh, M Shahsavan. Teratogenic effects of long term consumption of potassium benzoate on eye development in Balb/c fetal mice. Iranian Journal of Basic Medical Sciences 16 (4):584-589 (2013).
 
- Behravan E, SA Moallem, S Khateri, E Maraghi, P Jowsey, PG Blain, M Balali-Mood. Deoxyribonucleic acid damage in Iranian veterans 25 years after wartime exposure to sulfur mustard. Journal of Research in Medical Sciences. 18 (3):239-244 (2013).
 
- Malaekeh B, SH Moosavi, S Shahsavand, S Mehri, H Nassirli, SA Moallem. Assessment of cytotoxic properties of safranal and nanoliposomal safranal in various cancer cell lines. Phytotherapy Research 27:1868-1873 (2013).
 
- Ghorbani M, SA Moallem, K Abnous, SA Tabatabaee Yazdi, AR Movassaghi, M Azizzadeh, AH Mohamadpour. The effect of granulocyte colony-stimulating factor administration on carbon monoxide neurotoxicity in rats. Drug and Chemical Toxicology 36 (1):102-108 (2013).
 
- Afshar M, SA Moallem, J Khayatzadeh, N Taherian. Effect of carbamazepine on homocysteine level in pregnant mice and fetal malformations outcome.Journal of Gorgan University of Medical Sciences 15 (1):45-51 (2013).
 
- Etemad L, M Moshiri, SA Moallem. Epilepsy drugs and effects on fetal development: potential mechanisms. Journal of Research in Medical Sciences 17 (9):876-881 (2012).
 
- Badieyan ZS, SA Moallem, S Mehri, S Shahsavand, F Hadizadeh. Virtual screening for finding novel COX-2 inhibitors as antitumor agents. The Open Medicinal Chemistry Journal 6:15-19 (2012).
 
- Hosseinzadeh H, SA Moallem, M Moshiri, MS Sarnavazi, L Etemad. Anti-nociceptive and anti-inflammatory effects of cyanocobalamin (vitamin B12) against acute and chronic pain and inflammation in mice.Arzneimittelforschung (Drug Research) 62:324-329 (2012).
 
- Moallem SA, F. Hadizadeh, E Saber Farimani, M. Rameshrad, M. Allahyari. Synthesis and immunomodulation of human lymphocyte proliferation and cytokine (interferon gamma) production of four novel leflunomide analogues. Medicinal Chemistry 8:799-804 (2012).
 
- Moallem SA, F. Hadizadeh, F. Abdol Abadi, M. Shahraki, J. Shamsara. Synthesis and evaluation of pyridinyltriazoles as inhibitors of p38 MAP kinase. Iranian Journal of Basic Medical Sciences 15 (4):945-950 (2012).
 
- Asgharian Rezaee M, SA Moallem, M Imenshahidi, M Farzadnia, AH Mohammadpour. Effects of erythropoietin on electrocardiogram changes in carbon monoxide poisoning: an experimental study in rats. Iranian Journal of Pharmaceutical Research 11(4):1191-1199 (2012).
 
- Mohamadpour AH, SA Moallem, M Hashemzaei, K Abnous, SA Tabatabaee Yazdi, M Imanshahidi. Effects of granulocyte colony-stimulating factor on electrocardiogram changes after carbon monoxide poisoning in rats. Drug and Chemical Toxicology 35 (4): 353-360 (2012).
 
- Shahsavand S, AH Mohammadpour, R Rezayee, E Behravan, R Sakhtianchi, SA Moallem. Effect of erythropoietin on serum brain-derived biomarkers after carbon monoxide poisoning in rats. Iranian Journal of Basic Medical Sciences 15 (2):752-758 (2011).
 
- Moallem SA, F Hadizadeh, I Yavar. New N-aryl-4-(methysulfonyl)aminobenzenesulfonamides as selective COX-2 inhibitors. Journal of Biological Sciences 11 (8):496-499 (2011).
 
- Khayatzadeh J, M Afshar, SA Moallem, M Shahsavan, GH Naseh. Effect of potassium benzoate on Balb/c mice placenta: a histological study. Journal of Gorgan University of Medical Sciences 13 (1): 8-15 (2011).
 
- Mohammadpour AH, F. Nazemian, SA Moallem, SA Alamdaran. E. Asad Abadi, J. Shamsara. Correlation between heat shock protein 27 serum concentration and common carotid intima-media thickness in hemodialysis patients. Iranian Journal of Kidney Diseases 5 (4):260-266 (2011).
 
- Mousavi SH, SA Moallem, S. Mehri, S. Shahsavand, H. Nassirli, B. Malaekeh-Nikouei. Improvement of cytotoxic and apoptogenic properties of crocin in cancer cell lines by its liposomal form. Pharmaceutical Biology 49 (10):1039-1045 (2011).
 
- Afshar M, SA Moallem, J Baharara, T Takjo, MJ Golalipour. Preventive effect of vitamin B6 on developmental toxicity of carbamazepine in mice. Iranian Journal of Basic Medical Sciences 14 (2):99-106 (2011).
 
- Timcheh Hariri A, SA Moallem, M Mahmoudi, H Hosseinzadeh. The effect of crocin and safranal, constituents of saffron, against subacute effect of diazinon on hematological and genotoxicity indices in rats. Phytomedicine 18 (6):499-504 (2011).
 
- Moallem SA, A Ahmadi, M Moshafi, MM Taghavi. Teratogenic effects of HESA-A, a natural anticancer product from Iran, in mice. Human and Experimental Toxicology 30 (8):851-859 (2011).
 
- Moallem SA, F Nazemian, S Eliasi, SA Alamdaran, J Shamsara, AH Mohammadpour. Correlation between cathepsin D serum concentration and carotid intima-media thickness in hemodialysis patients. International Urology and Nephrology 43 (3):841-848 (2011).
 
- Timcheh Hariri A, SA Moallem, M Mahmoudi, B Memar, H Hosseinzadeh. Subacute effects of diazinon on biochemical indices and specific biomarkers in rats: protective effects of crocin and safranal. Food and Chemical Toxicology 48 (10):2803-2808 (2010).
 
- Afshar M, SA Moallem, J Baharara, T Takjo. The protective role of folic acid on teratogenic effect of carbamazepine in Balb/c mice. Journal of Gorgan University of Medical Sciences 12 (3):1-9 (2010).
 
- Afshar M, SA Moallem, AH Mohamadpoor, A Shiravi, SM Jalalian, MJ Golalipour. Teratogenic effects of carbamazepine on embryonic eye development in pregnant mice. Cutaneous and Ocular Toxicology 29 (1):10-15 (2010).
 
- Moallem SA, G Karimi, M Hassanzadeh Khayyat, M Bozorgi, A Nili-Ahmadabadi, F Nazari.Exposure assessment for mercury from consumption of marine fish in Iran. Toxicological and Environmental Chemistry 92 (6):1213-1218 (2010).
 
- Afshar M, MM Hasanzadeh, SA Moallem, A Tamizi, MJ Golalipour. Comparative study of teratogenic effects of gabapentin administration via peritoneum and gavages on skeletal system of mice fetuses using alizarin red S and alcian-blue staining techniques. Journal of Iran University of Medical Sciences 16 (68):7-18 (2010).
 
- Moallem SA, A Ahmadi, M Nyapour, T Hosseini, G Habibi.Role of apoptosis in HESA-A teratogenicity in mice fetus.Drug and Chemical Toxicology 32 (3):186-190 (2009).
 
- Afshar M, MM Hassanzadeh-Taheri, SA Moallem, A Tamizi, MJ Golalipour. Teratogenic effects of gabapentin on the skeletal system of Balb/C mice fetuses. Neurosciences 14 (3):239-244 (2009).
 
- Taghavi MM, SA Moallem, SH Alavi. The evaluation of single dose effects of methamphetamine on proliferation and apoptosis of sperm germ cells in mature rat. Journal of Isfahan Medical School 27 (97):400-409 (2009).
 
- Moallem SA, A Farahmand-Darzab, AH Sahebkar, M Iranshahi. Antiemetic activity of different extracts from the aerial parts of Thymus transcaspicus KLOKOV. Pharmacologyonline 1:1284-1292 (2009).
 
- Hadizadeh F, SA Moallem, MR Jaafari, M Shahab, M Rameshrad, A Samiee. Synthesis and immunomodulation of human lymphocyte proliferation and cytokine (INF-gamma) production of four novel malonitrilamides. Chemical Biology and Drug Design 73:668-673 (2009).
 
- Afshar M, SA Moallem, A Shiravi, SM Jalalian-Hosseini. Eye malformations induced by carbamazepine in mice. Journal of Gorgan University of Medical Sciences 10 (2):11-16 (2008).
 
- Afshar M, SA Moallem, M Jalilian, M Golalipoor.Eye malformation induced by carbamazepine in fetus of Balb/c mice: histological findings.Toxicology Letters 180 (1):S150 (2008)
 
- Moallem SA, M Bahadori. The role of apoptosis in Perovskia-abrotanoides-induced teratogenecity in mice. Toxicology Letters 180 (1):S38 (2008).
 
- Moallem SA, M Niapour. Study of embryotoxicity of Perovskia abrotanoides, an adulterant in folk-medicine, during organogenesis in mice. Journal of Ethnopharmacology 117:108-114 (2008).
 
- Alavi SH, MM Taghavi, SA Moallem. Evaluation of effects of Methamphetamine repeated dosing on proliferation and apoptosis of rat germ cells. Systems Biology in Reproductive Medicine 54:85-91 (2008).
 
- Moallem SA, H Hosseinzadeh, S Farahi. A Study of acute and chronic antinociceptive and anti-inflammatory effects of thiamine in mice. Iranian Biomedical Journal 12 (3):173-178 (2008).
 
- Moallem SA, H Hosseinzadeh, Z Izadi , ST Ziayee, T Kermani. Evaluation of teratogenecity of Salvia leriifolia in mice. Medicinal Plants 7 (2):1-9(2008).
 
- Taghavi MM, SH Alavi, SA Moallem, A Varasteh. Study of metamphetamine effects on rat sperm morphology. Journal of Kerman University of Medical Sciences 15 (10):61-69 (2008).
 
- Moallem M, A Ghorbani, SA Moallem, M Balali, H Solhi. Determining residual concentration of diazinon in agricultural products (melon and cucumber) with GC-NPD and GC-MS methods. Iranian Journal of Toxicology. 1 (2):72-77 (2007).
 
- Moallem SA, H Hosseinzadeh, F Ghoncheh. Evaluation of antidepressant effects of aerial parts of Echium vulgare in mice. Iranian Journal of Basic Medical Sciences 10 (3):84-89 (2007).
 
- Jahangiri L, SA Moallem, T Foroutan, A Hosseini, F Nazemian. Characterization and transdifferentiation of human mesothelial stem/progenitor cells of the peritoneum cavity. Journal of Biological Sciences 7 (7): 1179-1186 (2007).
 
- Moallem SA, L Jahangiri. On the track of mesothelial progenitor cells from the peritoneal cavity transplanted to immunocompetent mice. Pakistan Journal of Biological Sciences 10 (17):2790-2799 (2007).
 
- Moallem SA, A Ahmadi, MH Moshafi, MM Taghavi. Evaluation of fetal toxicity of HESA-A, a natural anticancer agent, in mice. Journal of Kerman University of Medical Sciences 14 (2):124-133 (2007).
 
- Pishdadian A, J Tavakkol Afshari, M Mahmoudi, M. Foroughi Poor, SA Moallem, SR Shahami, MA Fahmideh Kar, A Zamani. Detection of the soluble form of the Fas/Apo-1 receptor in patients with human T-lymphotropic virus type 1-associated myelopathy. Iranian Journal of Basic Medical Sciences 9 (2):144-152 (2006).
 
- Abolghasemi S, N Razmjo, SA Moallem, H Esmayeli. Effect of ginger capsules on nausea and vomiting during pregnancy. Journal of Babol University of Medical Sciences 6 (3):17-20 (2004).
 
- Moallem SA, T Afzali, M Niapour. The teratogenecity of Ginger officinale in mice. Iranian Journal of Basic Medical Sciences 6 (1):43-52 (2003).
 
- Moallem SA, BF Hales. The role of p53 and cell death by apoptosis and necrosis in 4‑hydroperoxycyclophosphamide‑induced limb malformations. Development 125:3225‑3234 (1998).
 
- Moallem SA, BF Hales. Transglutaminase and clusterin induction during normal and abnormal limb development. Biology of Reproduction 55:281-290 (1996).
 
- Moallem SA, BF Hales. Induction of apoptosis and cathepsin D in limbs exposed in vitro to an activated analog of cyclophosphamide. Teratology 52:3-14 (1995).